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Aluminum hydroxide (Al (OH) 3)

RTECS #: BD0940000

CAS #: 21645-51-2


UPDATE: May 2009 MW: 78.01 MF: AlH3O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. AF 260
  2. Alcoa 331
  3. Alcoa C 30BF
  4. Alumigel
  5. Alumina hydrated
  6. Alumina trihydrate
  7. Aluminic acid
  8. Aluminium hydroxide
  9. Aluminum hydrate
  10. Aluminum hydroxide
  11. Aluminum hydroxide gel
  12. Aluminum oxide trihydrate
  13. Aluminum trihydrate
  14. Aluminum trihydroxide
  15. Aluminum (III) hydroxide
  16. Alusal
  17. Amberol ST 140F
  18. Amphojel
  19. BACO AF 260
  20. British aluminum AF 260
  21. C 31
  22. C 31C
  23. C 31F
  1. C 33
  2. C 4D
  3. C - 31 - F
  4. C.I. 77002
  5. GHA 331
  6. GHA 332
  7. H 46
  8. Higilite
  9. Higilite H 31S
  10. Higilite H 32
  11. Higilite H 42
  12. Hychol 705
  13. Hydral 705
  14. Hydral 710
  15. Hydrated alumina
  16. Liquigel
  17. Martinal
  18. P 30BF
  19. PGA
  20. Trihydrated alumina
  21. Trihydroxyaluminum
  22. alpha - Alumina trihydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
woman
lowest published toxic dose: 84 gm/kg (1-40 week pregnant) Reproductive: Effects on newborn: Physical APAMEB 152,511,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published lethal dose: 150 mg/kg N/R LANCAO 1,564,1972
oral
child
lowest published toxic dose: 79 gm/kg/2 year- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity

Musculoskeletal: Osteomalacia
PEDIAU 71,56,1983
oral
child
lowest published toxic dose: 122 gm/kg/4 day Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Body temperature increase
JOPDAB 92,592,1978
oral
rat
lowest published toxic dose: 15 mg/kg Gastrointestinal: Other changes FTRPAE 70,542,1999
unreported route
infant
lowest published toxic dose: 39 gm/kg/24 day- intermittent Musculoskeletal: Osteomalacia NEJMAG 310,1079,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 6,240 mg/kg/26 week- intermittent Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Fe
TOLED5 111,235,2000
intraperitoneal
rat
lowest published toxic dose: 1,920 mg/kg/8 week- intermittent Blood: Microcytosis with or without anemia TOLED5 111,235,2000
intraperitoneal
rat
lowest published toxic dose: 960 mg/kg/4 week- intermittent Blood: Changes in erythrocyte (RBC) count TOLED5 111,235,2000
oral
infant
lowest published toxic dose: 68,040 mg/kg/24 week- intermittent Musculoskeletal: Osteoporosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P
APHRER 38,265,2004
oral
mouse
lowest published toxic dose: 80,880 mg/kg/23 week- continuous Liver: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
PHTOEH 86,135,2000
oral
rat
lowest published toxic dose: 8,040 mg/kg/67 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P
FAATDF 10,616,1988
oral
woman
lowest published toxic dose: 73,912.5 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Osteoporosis

Nutritional and Gross Metabolic: Changes in: P
APHRER 38,265,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BPCEM* 17,237,2003
TOXICOLOGY REVIEW
TIHEEC 18,309,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit - FRANCE VME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1.5 mg/m3 (respirable), 2005
Occupational Exposure Limit - KOREA time-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 6 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg(Al)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 3 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80390;
Number of Industries 85;
Total Number of Facilities 4,981;
Number of Occupations 74;
Total Number of Employees Exposed 97,261
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4445;
Number of Industries 2;
Total Number of Facilities 297;
Number of Occupations 8;
Total Number of Employees Exposed 37,773;
Total Number of Female Employees Exposed 33,522
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9931;
Number of Industries 1;
Total Number of Facilities 59;
Number of Occupations 4;
Total Number of Employees Exposed 7,006;
Total Number of Female Employees Exposed 6,697
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80390;
Number of Industries 123;
Total Number of Facilities 12,057;
Number of Occupations 121;
Total Number of Employees Exposed 325,788;
Total Number of Female Employees Exposed 84,539


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in cosmetics and pharmaceuticals, also used as flame-retardant
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

APAMEB Archives of Pediatrics and Adolescent Medicine. (American Medical Association, 515 N State St., Chicago, IL 60610) V.148- 1994-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in cosmetics and pharmaceuticals, also used as flame-retardant

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRC, 1/81

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 1302-29-0
ALT CAS #: 12252-70-9
ALT CAS #: 51330-22-4
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