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Registry of Toxic Effects of Chemical Substances (RTECS)

Aluminum hydroxide (Al(OH)3)

RTECS #

BD0940000

CAS #

21645-51-2; 1302-29-0; 12252-70-9; 51330-22-4

Updated

September 201

Molecular Weight

78.01

Molecular Formula

AlH3O3

Synonyms

AF 260
Alcoa 331
Alcoa C 30BF
alpha-Alumina trihydrate
Alumigel
Alumina hydrated
Alumina trihydrate
Aluminic acid
Aluminium hydroxide
Aluminum hydrate
Aluminum hydroxide
Aluminum hydroxide gel
Aluminum oxide trihydrate
Aluminum trihydrate
Aluminum trihydroxide
Aluminum(III) hydroxide
Alusal
Amberol ST 140F
Amphojel
BACO AF 260
British aluminum AF 260
C 31
C 31C
C 31F
C 33
C 4D
C.I. 77002
C-31-F
GHA 331
GHA 332
H 46
Higilite
Higilite H 31S
Higilite H 32
Higilite H 42
Hychol 705
Hydral 705
Hydral 710
Hydrated alumina
Liquigel
Martinal
P 30BF
PGA
Trihydrated alumina
Trihydroxyaluminum

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/woman 84 gm/kg (1-40W pregnant)Reproductive: Effects on newborn: PhysicalAPAMEB 152,511,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published lethal dose: 150 mg/kgLANCAO 1,564,1972
oral/child lowest published toxic dose: 79 gm/kg/2Y- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity

Musculoskeletal: Osteomalacia
PEDIAU 71,56,1983
oral/child lowest published toxic dose: 122 gm/kg/4DGastrointestinal: Other changes

Nutritional and Gross Metabolic: Body temperature increase
JOPDAB 92,592,1978
oral/rat lowest published toxic dose: 15 mg/kgGastrointestinal: Other changesFTRPAE 70,542,1999
unreported route/infant lowest published toxic dose: 39 gm/kg/24D- intermittentMusculoskeletal: OsteomalaciaNEJMAG 310,1079,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 1920 mg/kg/8W- intermittentBlood: Microcytosis with or without anemiaTOLED5 111,235,2000
intraperitoneal/rat lowest published toxic dose: 960 mg/kg/4W- intermittentBlood: Changes in erythrocyte (RBC) countTOLED5 111,235,2000
intraperitoneal/rat lowest published toxic dose: 6240 mg/kg/26W- intermittentBlood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Fe
TOLED5 111,235,2000
oral/infant lowest published toxic dose: 68040 mg/kg/24W- intermittentMusculoskeletal: Osteoporosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P
APHRER 38,265,2004
oral/mouse lowest published toxic dose: 80880 mg/kg/23W- continuousLiver: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
PHTOEH 86,135,2000
oral/rat lowest published toxic dose: 8040 mg/kg/67D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P
FAATDF 10,616,1988
oral/woman lowest published toxic dose: 73912.5 mg/kg/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Osteoporosis

Nutritional and Gross Metabolic: Changes in: P
APHRER 38,265,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg(Al)/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWBPCEM* 17,237,2003
TOXICOLOGY REVIEWTIHEEC 18,309,2002
TOXICOLOGY REVIEWMUREAV 750,1,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 2 mg(Al)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 6 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Al)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 3 mg/m3, resp, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 mg(Al)/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4445; Number of Industries 2; Total Number of Facilities 297; Number of Occupations 8; Total Number of Employees Exposed 37773; Total Number of Female Employees Exposed 33522
National Occupational Exposure Survey 1983Hazard Code X9931; Number of Industries 1; Total Number of Facilities 59; Number of Occupations 4; Total Number of Employees Exposed 7006; Total Number of Female Employees Exposed 6697
National Occupational Exposure Survey 1983Hazard Code 80390; Number of Industries 123; Total Number of Facilities 12057; Number of Occupations 121; Total Number of Employees Exposed 325788; Total Number of Female Employees Exposed 84539
National Occupational Hazard Survey 1974Hazard Code 80390; Number of Industries 85; Total Number of Facilities 4981; Number of Occupations 74; Total Number of Employees Exposed 97261

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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