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Aluminum chloride

RTECS #: BD0525000

CAS #: 7446-70-0


UPDATE: May 2009 MW: 133.33 MF: AlCl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alluminio (cloruro di) (Italian)
  2. Aluminium chloride
  3. Aluminiumchlorid (German)
  4. Aluminum chloride (1:3)
  1. Aluminum trichloride
  2. Chlorure d'aluminium (French)
  3. Pearsall
  4. Trichloroaluminum


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
10%/6 day- intermittent VCVN1* -,219,1988
skin
mouse
10% open irritation test severe BJDEAZ 89,67,1973
skin
pig
10% open irritation test severe BJDEAZ 89,67,1973
skin
rabbit
10%/6 day- intermittent VCVN1* -,219,1988
skin
rabbit
10% open irritation test severe BJDEAZ 89,67,1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 5 µmol/L/1 hour FCTOD7 45,1154,2007
cytogenetic analysis intraperitoneal
mouse
444 mg/kg NULSAK 15,180,1972
DNA damage human lymphocyte 2 mg/L/72 hour TOLED5 161,27,2006
DNA damage human lymphocyte 5 µmol/L/3 hour FCTOD7 45,1154,2007
DNA damage rat Ascites tumor 500 µmol/L JBCHA3 261,3370,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 600 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TEELEO 16,192,1999
intraperitoneal
rat
lowest published toxic dose: 375 mg/kg (9-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ANANAU 138,365,1975
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg (14-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ANANAU 138,365,1975
oral
mouse
lowest published toxic dose: 425 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BJIMAG 23,305,1966
oral
rat
lowest published toxic dose: 11,512 mg/kg (8-22 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NTOTDY 8,115,1986
oral
rat
lowest published toxic dose: 5,723 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Behavioral
TJADAB 40,21,1989
oral
rat
lowest published toxic dose: 900 mg/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
JTSCDR 18,43,1993
oral
rat
lowest published toxic dose: 5,520 mg/kg (1-16 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 21,313,2006
oral
rat
lowest published toxic dose: 5,520 mg/kg (1-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
REPTED 21,313,2006
oral
rat
lowest published toxic dose: 5,520 mg/kg (1-16 day pregnant) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Biochemical and metabolic
REPTED 21,313,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 96 mg/kg N/R VCVN1* -,212,1988
intraperitoneal
rat
lethal dose (50 percent kill): 333 mg/kg N/R VCVN1* -,212,1988
oral
mouse
lethal dose (50 percent kill): 1,130 mg/kg N/R VCVN1* -,212,1988
oral
rat
lethal dose (50 percent kill): 3,450 mg/kg Brain and Coverings: Other degenerative changes

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Hematuria
SRTCAC 36(1-4),10,1989
skin
mouse
lowest published toxic dose: 10 pph Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BJDEAZ 89,67,1973
skin
pig
lowest published toxic dose: 10 pph Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BJDEAZ 89,67,1973
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R EPASR* 8EHQ-0191-1109
skin
rabbit
lowest published toxic dose: 10 pph Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BJDEAZ 89,67,1973
unreported route
mouse
lethal dose (50 percent kill): 390 mg/kg N/R GISAAA 43(4),12,1978
unreported route
rat
lethal dose (50 percent kill): 315 mg/kg N/R GISAAA 43(4),12,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lowest published toxic dose: 1,000 µg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests
EJPHAZ 547,52,2006
intraperitoneal
mouse
lowest published toxic dose: 420 mg/kg/12 day- intermittent Endocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Lipids including transport
ETOPFR 19,33,2005
intraperitoneal
rat
lowest published toxic dose: 99 mg/kg/5 day- intermittent Musculoskeletal: Osteomalacia KDYIA5 23,327,1983
intraperitoneal
rat
lowest published toxic dose: 415 mg/kg/21 day- intermittent Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EESADV 33,201,1996
intraperitoneal
rat
lowest published toxic dose: 3,083 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NPRNAY 47,66,1987
intravenous
rat
lowest published toxic dose: 15 mg/kg/3 day- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
CBPCEE 105,73,1993
oral
mouse
lowest published toxic dose: 8,421 mg/kg/40 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Changes in: Other metals
BJIMAG 23,305,1966
oral
mouse
lowest published toxic dose: 138 gm/kg/34 week- continuous Gastrointestinal: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Fe
PHTOEH 86,135,2000
oral
rat
lowest published toxic dose: 9,380 mg/kg/52 day- intermittent Nutritional and Gross Metabolic: Changes in: P BJIMAG 23,305,1966
oral
rat
lowest published toxic dose: 2,307 mg/kg/26 week- intermittent Behavioral: Change in motor activity (specific assay)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
EVHPAZ 30,47,1979
oral
rat
lowest published toxic dose: 100 gm/kg/48 week- continuous Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning
NTOTDY 4,403,1982
oral
rat
lowest published toxic dose: 1,280 mg/kg/4 day- intermittent Brain and Coverings: Other degenerative changes TOXID9 72,74,2003
oral
rat
lowest published toxic dose: 30 gm/kg/80 day- continuous Brain and Coverings: Recordings from specific areas of CNS FCTOD7 40,471,2002
oral
rat
lowest published toxic dose: 1,904 mg/kg/16 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 199,47,2004
oral
rat
lowest published toxic dose: 5,520 mg/kg/16 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
REPTED 21,301,2006
oral
rat
lowest published toxic dose: 5,520 mg/kg/16 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
REPTED 21,301,2006
oral
rat
: 1,750 mg/kg/5 week- continuous Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
NRTXDN 27,451,2006
oral
rat
lowest published toxic dose: 4,200 mg/kg/6 week- intermittent Brain and Coverings: Other degenerative changes FCTOD7 45,2499,2007
oral
rabbit
lowest published toxic dose: 3,808 mg/kg/16 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
TXCYAC 215,97,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Al)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CRTXB2 33,215,2003
TOXICOLOGY REVIEW
TIHEEC 18,309,2002
TOXICOLOGY REVIEW
NETEEC 29,425,2007
TOXICOLOGY REVIEW
HBTME* ,339,2007
TOXICOLOGY REVIEW
HBTME* ,213,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,295,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit - FRANCE VME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 2 mg(Al)/m3, short term exposure limit 6 mg(Al)/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg(Al)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Al)/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg(Al)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg(Al)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 04605;
Number of Industries 29;
Total Number of Facilities 3,476;
Number of Occupations 34;
Total Number of Employees Exposed 17,152
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 04605;
Number of Industries 32;
Total Number of Facilities 2,230;
Number of Occupations 68;
Total Number of Employees Exposed 49,913;
Total Number of Female Employees Exposed 17,460


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as ETHYLBENZENE catalyst, dyestuff intermediate and detergent alkylate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NPRNAY Nephron. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TEELEO Trace Elements and Electrolytes. (Dustri-Verlag Dr. Karl Feistle, Postfach 1351 D-82032 Muenchen-Deisenhofen, Germany) V.11- 1994-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as ETHYLBENZENE catalyst, dyestuff intermediate and detergent alkylate

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRI, 2/77

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRC, 1/81

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Organometallic
   Mutagen
   Reproductive Effector
   Hormone
   Primary Irritant

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