Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Aluminum chloride

RTECS #

BD0525000

CAS #

7446-70-0

Updated

September 201

Molecular Weight

133.33

Molecular Formula

AlCl3

Synonyms

Alluminio(cloruro di) (Italian)
Aluminium chloride
Aluminiumchlorid (German)
Aluminum chloride (1:3)
Aluminum trichloride
Chlorure d'aluminium (French)
Pearsall
Trichloroaluminum

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /mouse 10%/6D- intermittentVCVN1* -,219,1988
skin /mouse 10% open irritation test severeBJDEAZ 89,67,1973
skin /mouse 10%BJDEAZ 89,67,1973
skin /pig 10%BJDEAZ 89,67,1973
skin /pig 10% open irritation test severeBJDEAZ 89,67,1973
skin /rabbit 10%BJDEAZ 89,67,1973
skin /rabbit 10%/6D- intermittentVCVN1* -,219,1988
skin /rabbit 10% open irritation test severeBJDEAZ 89,67,1973

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse444 mg/kgNULSAK 15,180,1972
Cytogenetic Analysislymphocyte/human5 µmol/L/1HFCTOD7 45,1154,2007
DNA Damagefibroblast/other fish50 µmol/L/24HMUREAV 750,19,2013
DNA Damagelymphocyte/human2 mg/L/72HTOLED5 161,27,2006
DNA Damagelymphocyte/human5 µmol/L/3HFCTOD7 45,1154,2007
DNA DamageAscites tumor/rat500 µmol/LJBCHA3 261,3370,1986
micronucleus testfibroblast/other fish5 µmol/L/24HMUREAV 750,19,2013
specific locus testfibroblast/other fish5 µmol/L/24HMUREAV 750,19,2013

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 375 mg/kg (9-13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ANANAU 138,365,1975
intraperitoneal/rat 500 mg/kg (14-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemANANAU 138,365,1975
intraperitoneal/mouse 600 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TEELEO 16,192,1999
oral/rat 5520 mg/kg (1-16D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 21,313,2006
oral/rat 5520 mg/kg (1-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
REPTED 21,313,2006
oral/rat 5520 mg/kg (1-16D pregnant)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Biochemical and metabolic
REPTED 21,313,2006
oral/rat 2380 mg/kg (70D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
FCTOD7 47,1168,2009
oral/mouse 425 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)BJIMAG 23,305,1966
oral/rat 11512 mg/kg (8-22D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NTOTDY 8,115,1986
oral/rat 5723 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Behavioral
TJADAB 40,21,1989
oral/rat 900 mg/kg (15D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
JTSCDR 18,43,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 96 mg/kgVCVN1* -,212,1988
intraperitoneal/rat lethal dose (50 percent kill): 333 mg/kgVCVN1* -,212,1988
oral/mouse lethal dose (50 percent kill): 1130 mg/kgVCVN1* -,212,1988
oral/rat lethal dose (50 percent kill): 3450 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Hematuria
SRTCAC 36(1-4),10,1989
skin/rabbit lethal dose (50 percent kill): >2 gm/kgEPASR* 8EHQ-0191-1109
unreported route/mouse lethal dose (50 percent kill): 390 mg/kgGISAAA 43(4),12,1978
unreported route/rat lethal dose (50 percent kill): 315 mg/kgGISAAA 43(4),12,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intracerebral/mouse lowest published toxic dose: 1000 µg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests
EJPHAZ 547,52,2006
intraperitoneal/mouse lowest published toxic dose: 420 mg/kg/12D- intermittentEndocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Lipids including transport
ETOPFR 19,33,2005
intraperitoneal/rat lowest published toxic dose: 99 mg/kg/5D- intermittentMusculoskeletal: OsteomalaciaKDYIA5 23,327,1983
intraperitoneal/rat lowest published toxic dose: 415 mg/kg/21D- intermittentBlood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EESADV 33,201,1996
intraperitoneal/rat lowest published toxic dose: 3083 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)NPRNAY 47,66,1987
intraperitoneal/rat lowest published toxic dose: 150 mg/kg/10D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 50,1302,2012
intravenous/rat lowest published toxic dose: 15 mg/kg/3D- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
CBPCEE 105,73,1993
oral/mouse lowest published toxic dose: 8421 mg/kg/40D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Changes in: Other metals
BJIMAG 23,305,1966
oral/mouse lowest published toxic dose: 138 gm/kg/34W- continuousGastrointestinal: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Fe
PHTOEH 86,135,2000
oral/mouse lowest published toxic dose: 8400 mg/kg/12W- intermittentBehavioral: Alteration of classical conditioningFCTOD7 49,2906,2011
oral/mouse lowest published toxic dose: 12600 mg/kg/18W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
FCTOD7 49,2906,2011
oral/rabbit lowest published toxic dose: 3808 mg/kg/16W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
TXCYAC 215,97,2005
oral/rat lowest published toxic dose: 5520 mg/kg/16D- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
REPTED 21,301,2006
oral/rat lowest published toxic dose: 5520 mg/kg/16D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
REPTED 21,301,2006
oral/rat : 1750 mg/kg/5W- continuousBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
NRTXDN 27,451,2006
oral/rat lowest published toxic dose: 4200 mg/kg/6W- intermittentBrain and Coverings: Other degenerative changesFCTOD7 45,2499,2007
oral/rat lowest published toxic dose: 2380 mg/kg/70D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 47,1093,2009
oral/rat lowest published toxic dose: 2380 mg/kg/70D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
FCTOD7 47,1168,2009
oral/rat lowest published toxic dose: 2000 mg/kg/20D- intermittentBehavioral: Alteration of classical conditioningBCLPT* 105,98,2009
oral/rat lowest published toxic dose: 4200 mg/kg/6W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
BCLPT* 105,98,2009
oral/rat lowest published toxic dose: 1280 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changesTOXID9 72,74,2003
oral/rat lowest published toxic dose: 30 gm/kg/80D- continuousBrain and Coverings: Recordings from specific areas of CNSFCTOD7 40,471,2002
oral/rat lowest published toxic dose: 1904 mg/kg/16W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 199,47,2004
oral/rat lowest published toxic dose: 31.5 gm/kg/90D- continuousBrain and Coverings: Other degenerative changes

Brain and Coverings: Changes in brain weight
FCTOD7 50,315,2012
oral/rat lowest published toxic dose: 7701.6 mg/kg/120D- continuousImmunological Including Allergic: Decrease in cellular immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 50,532,2012
oral/rat lowest published toxic dose: 1925.4 mg/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 50,2911,2012
oral/rat lowest published toxic dose: 7701.6 mg/kg/120D- continuousEndocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 50,2911,2012
oral/rat lowest published toxic dose: 15403.2 mg/kg/120D- continuousBlood: Changes in spleen

Nutritional and Gross Metabolic: Changes in: Fe

Nutritional and Gross Metabolic: Changes in: Other metals
FCTOD7 50,2911,2012
oral/rat lowest published toxic dose: 9380 mg/kg/52D- intermittentNutritional and Gross Metabolic: Changes in: PBJIMAG 23,305,1966
oral/rat lowest published toxic dose: 2307 mg/kg/26W- intermittentBehavioral: Change in motor activity (specific assay)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
EVHPAZ 30,47,1979
oral/rat lowest published toxic dose: 100 gm/kg/48W- continuousBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning
NTOTDY 4,403,1982

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTXB2 33,215,2003
TOXICOLOGY REVIEWTIHEEC 18,309,2002
TOXICOLOGY REVIEWNETEEC 29,425,2007
TOXICOLOGY REVIEWHBTME* ,339,2007
TOXICOLOGY REVIEWHBTME* ,213,2007
TOXICOLOGY REVIEWARTODN 83,965,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,295,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 2 mg(Al)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 2 mg(Al)/m3, short term exposure limit 6 mg(Al)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Al)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Al)/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 04605; Number of Industries 32; Total Number of Facilities 2230; Number of Occupations 68; Total Number of Employees Exposed 49913; Total Number of Female Employees Exposed 17460
National Occupational Hazard Survey 1974Hazard Code 04605; Number of Industries 29; Total Number of Facilities 3476; Number of Occupations 34; Total Number of Employees Exposed 17152

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone marrow
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP