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Aluminum sulfate (2:3)

RTECS #: BD1700000

CAS #: 10043-01-3


UPDATE: May 2009 MW: 342.14 MF: O12S32Al


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alum
  2. Aluminum alum
  3. Aluminum sulfate
  4. Aluminum trisulfate
  1. Cake alum
  2. Dialuminum sulphate
  3. Dialuminum trisulfate
  4. Sulfuric acid, aluminum salt (3:2)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
10 mg/24 hour severe NTIS** OTS0571939


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 20 mg/L MUREAV 244,179,1990
cytogenetic analysis oral
rat
762 mg/kg/7 day- continuous CYTBAI 66,105,1991
micronucleus test human lymphocyte 20 mg/L MUREAV 244,179,1990
other mutation test systems human lymphocyte 20 mg/L MUREAV 244,179,1990
other mutation test systems oral
rat
762 mg/kg/7 day- continuous CYTBAI 66,105,1991
sister chromatid exchange human lymphocyte 20 mg/L MUREAV 244,179,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 800 mg/kg (10-13 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
BNBIDY 59,136,1993
intratesticular
rat
lowest published toxic dose: 27,371 g/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous
mouse
lowest published toxic dose: 27,371 g/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 274 mg/kg N/R COREAF 256,1043,1963
oral
mouse
lethal dose (50 percent kill): 6,207 mg/kg N/R BJIMAG 23,305,1966
unreported route
guinea pig
lethal dose (50 percent kill): 490 mg/kg N/R GISAAA 43(4),12,1978
unreported route
mouse
lethal dose (50 percent kill): 520 mg/kg N/R GISAAA 43(4),12,1978
unreported route
rat
lethal dose (50 percent kill): 410 mg/kg N/R GISAAA 43(4),12,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1.1 gm/kg/13 week- intermittent Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 132,131,2002
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg/2 week- intermittent Blood: Other changes ARTODN 81,11,2007
oral
mouse
lowest published toxic dose: 300 gm/kg/60 day- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral
mouse
lowest published toxic dose: 910 gm/kg/0.5 year- continuous Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral
mouse
lowest published toxic dose: 1,400 gm/kg/40 week- intermittent Liver: Fatty liver degeneration

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
EXGER* 43,330,2008
oral
rat
lowest published toxic dose: 10,138 mg/kg/8 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: P
BJIMAG 23,305,1966
oral
rat
lowest published toxic dose: 186 gm/kg/60 day- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral
rat
lowest published toxic dose: 564.2 gm/kg/0.5 year- continuous Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral
rat
lowest published toxic dose: 29,538 mg/kg/72 week- intermittent Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Fe
TXCYAC 209,29,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Al)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
BIPHEX 58,325,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,295,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit - FRANCE VME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg(Al)/m3, short term exposure limit 2 mg(Al)/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg(Al)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Al)/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg(Al)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg(Al)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 04620;
Number of Industries 136;
Total Number of Facilities 21,057;
Number of Occupations 92;
Total Number of Employees Exposed 104,804
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1197;
Number of Industries 11;
Total Number of Facilities 2,133;
Number of Occupations 15;
Total Number of Employees Exposed 23,355;
Total Number of Female Employees Exposed 8,416
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8589;
Number of Industries 2;
Total Number of Facilities 394;
Number of Occupations 3;
Total Number of Employees Exposed 1,496
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 04620;
Number of Industries 117;
Total Number of Facilities 16,815;
Number of Occupations 111;
Total Number of Employees Exposed 212,242;
Total Number of Female Employees Exposed 57,674


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in paper industry, in waste and water treatment, in deodorants, in flame-retardants
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIPHEX Biomedicine & Pharmacotherapy (Editions Scientifiques et Medicales Elsevier, Journals Fulfilment Department, 23 rue Linois, F -75724 Paris Cedex 15, France OR Editions Scientifiques et Medicales Elsevier, P.O.BOX 7247-7576, Philadelphia, PA 19170-7576,USA) V. 36- Jan.1982-)
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BNBIDY Behavioral and Neural Biology. (Academic Press, Inc., 111 5th Ave., New York, NY 10003) V.25- 1979-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EXGER*
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in paper industry, in waste and water treatment, in deodorants, in flame-retardants

Top 50 chemical production: 2.18 billions lbs in 1992, 2.37 billions in 1991

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRI, 2/77

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRC, 1/81

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

Click Here for Additional Information about RTECS

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