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Registry of Toxic Effects of Chemical Substances (RTECS)

Aluminum sulfate (2:3)

RTECS #

BD1700000

CAS #

10043-01-3

Updated

July 2013

Molecular Weight

342.14

Molecular Formula

O12S3·2Al

Synonyms

Alum
Aluminum alum
Aluminum sulfate
Aluminum trisulfate
Cake alum
Dialuminum sulphate
Dialuminum trisulfate
Sulfuric acid, aluminum salt (3:2)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 10 mg/24H severeNTIS** OTS0571939

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human20 mg/LMUREAV 244,179,1990
Cytogenetic Analysisoral/rat762 mg/kg/7D-continuousCYTBAI 66,105,1991
micronucleus testlymphocyte/human20 mg/LMUREAV 244,179,1990
other mutation test systemslymphocyte/human20 mg/LMUREAV 244,179,1990
other mutation test systemsoral/rat762 mg/kg/7D-continuousCYTBAI 66,105,1991
sister chromatid exchangelymphocyte/human20 mg/LMUREAV 244,179,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 800 mg/kg (10-13D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
BNBIDY 59,136,1993
intratesticular/rat 27371 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous/mouse 27371 µg/kg (30D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 274 mg/kgCOREAF 256,1043,1963
oral/mouse lethal dose (50 percent kill): 6207 mg/kgBJIMAG 23,305,1966
unreported route/guinea pig lethal dose (50 percent kill): 490 mg/kgGISAAA 43(4),12,1978
unreported route/mouse lethal dose (50 percent kill): 520 mg/kgGISAAA 43(4),12,1978
unreported route/rat lethal dose (50 percent kill): 410 mg/kgGISAAA 43(4),12,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 1.1 gm/kg/13W- intermittentBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 132,131,2002
intraperitoneal/rat lowest published toxic dose: 30 mg/kg/2W- intermittentBlood: Other changesARTODN 81,11,2007
oral/mouse lowest published toxic dose: 1400 gm/kg/40W- intermittentLiver: Fatty liver degeneration

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
EXGER* 43,330,2008
oral/mouse lowest published toxic dose: 300 gm/kg/60D- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral/mouse lowest published toxic dose: 910 gm/kg/0.5Y- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral/rat lowest published toxic dose: 186 gm/kg/60D- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral/rat lowest published toxic dose: 564.2 gm/kg/0.5Y- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,242,2004
oral/rat lowest published toxic dose: 29538 mg/kg/72W- intermittentBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Fe
TXCYAC 209,29,2005
oral/rat lowest published toxic dose: 10138 mg/kg/8D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: P
BJIMAG 23,305,1966

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWBIPHEX 58,325,2004
TOXICOLOGY REVIEWJOETD7 132,28,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,295,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Al)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg(Al)/m3, short term exposure limit 2 mg(Al)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Al)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Al)/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1197; Number of Industries 11; Total Number of Facilities 2133; Number of Occupations 15; Total Number of Employees Exposed 23355; Total Number of Female Employees Exposed 8416
National Occupational Exposure Survey 1983Hazard Code X8589; Number of Industries 2; Total Number of Facilities 394; Number of Occupations 3; Total Number of Employees Exposed 1496
National Occupational Exposure Survey 1983Hazard Code 04620; Number of Industries 117; Total Number of Facilities 16815; Number of Occupations 111; Total Number of Employees Exposed 212242; Total Number of Female Employees Exposed 57674
National Occupational Hazard Survey 1974Hazard Code 04620; Number of Industries 136; Total Number of Facilities 21057; Number of Occupations 92; Total Number of Employees Exposed 104804

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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