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Registry of Toxic Effects of Chemical Substances (RTECS)

Aluminum phosphide

RTECS #

BD1400000

CAS #

20859-73-8; 1302-45-0; 71751-04-7

Updated

October 2011

Molecular Weight

57.95

Molecular Formula

AlP

Synonyms

AL-Phos
Aluminium fosfide (Dutch)
Aluminium phosphide (AlP)
Aluminum monophosphide
Celphide
Celphine
Celphos
Delicia
Delicia gastoxin
Detia
Detia gas Ex-B
Detia-Ex-B
Fosfuri di alluminio (Italian)
Fumitoxin
Gastion
Phosphures d'alumium (French)
Phostoxin
Quickphos
RCRA waste number P006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/man Lowest published lethal concentration: 2800 mg/m385ARAE 3,38,1976/1977
oral/human lowest published toxic dose: 85.71 mg/kgVascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Blood: Methemoglobinemia- Carboxhemoglobinemia
AJEMEN 20,130,2002
oral/human lowest published lethal dose: 0.073 gm/kgBehavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea
HETOEA 28,209,2009
oral/man lowest published toxic dose: 0.043 gm/kgCardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Cyanosis
HETOEA 26,457,2007
oral/man lowest published toxic dose: 0.086 gm/kgCardiac: EKG changes not diagnostic of above

Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
HETOEA 26,979,2007
oral/man lowest published toxic dose: 0.024 gm/kgCardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 45,728,2007
oral/man lowest published toxic dose: 21 mg/kgVascular: Other changes

Gastrointestinal: Gastritis
HUTODJ 7,343,1988
oral/man lowest published lethal dose: 86 mg/kgBehavioral: Coma

Vascular: Other changes

Gastrointestinal: Nausea or vomiting
HUTODJ 7,343,1988
oral/rat lowest published lethal dose: 10 mg/kgLung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
CYLPDN 22,37,2001
oral/rat lowest published lethal dose: 12.5 mg/kgCardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP
CYLPDN 22,298,2001
oral/rat lowest published toxic dose: 10 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 48,53,2010
oral/woman lowest published toxic dose: 0.1 gm/kgCardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 45,728,2007
oral/woman lowest published toxic dose: 60 mg/kgVascular: Other changes

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Gastritis
HUTODJ 7,343,1988
oral/woman lowest published lethal dose: 180 mg/kgCardiac: Pulse rate increased without fall in BP

Liver: Jaundice, other or unclassified

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HUTODJ 7,343,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,84,2005
TOXICOLOGY REVIEWHBTME* ,339,2007
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWJFLME* 16,312,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,84,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg(Al)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg(Al)/m3, MAR2002
Occupational Exposure Limit-FRANCEVME 2 mg(Al)/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 2 mg(Al)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg(Al)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 2 mg(Al)/m3, short term exposure limit 6 mg(Al)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Al)/m3, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84460; Number of Industries 3; Total Number of Facilities 190; Number of Occupations 4; Total Number of Employees Exposed 623
National Occupational Hazard Survey 1974Hazard Code 84460; Number of Industries 1; Total Number of Facilities 280; Number of Occupations 2; Total Number of Employees Exposed 12600

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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