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Allylamine

RTECS #: BA5425000

CAS #: 107-11-9


UPDATE: May 2008 MW: 57.11 MF: C3H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Propenamine
  2. 2 - Propen - 1 - amine (9CI)
  3. 3 - Aminopropene
  1. 3 - Aminopropylene
  2. Monoallylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg/20S rinse severe AEHLAU 1,343,1960
skin
rabbit
500 mg/24 hour severe AEHLAU 1,343,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
2,500 ng/kg GISAAA 48(1),80,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 320 mg/m3 N/R TPKVAL 14,80,1975
inhalation
man
lowest published toxic concentration: 2,500 ppb/5 minute Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
AEHLAU 1,343,1960
inhalation
rat
lethal concentration (50 percent kill): 177 ppm/8 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea
AEHLAU 1,343,1960
intraperitoneal
mouse
lethal dose (50 percent kill): 49 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AEHLAU 1,343,1960
intraperitoneal
rat
lowest published lethal dose: 37,500 g/kg N/R FATOAO 31,238,1968
oral
mammal (species unspecified)
lethal dose (50 percent kill): 78,300 g/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 57 mg/kg N/R AEHLAU 1,343,1960
oral
rat
lethal dose (50 percent kill): 102 mg/kg N/R 85GMAT -,17,1982
skin
rabbit
lethal dose (50 percent kill): 35 mg/kg Skin: After topical application: Primary irritation

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AEHLAU 1,343,1960
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 783 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 20 ppm/7 hour/50 day- intermittent Cardiac: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 1,343,1960
oral
rat
lowest published toxic dose: 1 gm/kg/11 day- intermittent Cardiac: Changes in coronary arteries

Cardiac: Other changes

Vascular: Structural changes in vessels
TXAPA9 103,288,1990
oral
rat
lowest published toxic dose: 6,240 mg/kg/15 week- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 50,581,1979
oral
rat
lowest published toxic dose: 700 mg/kg/20 day- intermittent Vascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 72,95,2003
oral
rat
lowest published toxic dose: 1,400 mg/kg/20 day- intermittent Vascular: Effect on gills and gill functions

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 66,9,2002
oral
rabbit
lowest published toxic dose: 4,500 g/kg/26 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 48(1),80,1983
unreported route
rat
lowest published toxic dose: 700 mg/kg/20 day- intermittent Vascular: Structural changes in vessels TOXID9 66,95,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TXCYAC 44,129,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (4.7 mg/m3), OCT 2002
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 ppm (5 mg/m3);
short term exposure limit 6 ppm (14 mg/m3), Skin, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0127;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 2;
Total Number of Employees Exposed 27


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of mercurial diuretics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in the manufacture of mercurial diuretics

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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