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Registry of Toxic Effects of Chemical Substances (RTECS)

Allylamine

RTECS #

BA5425000

CAS #

107-11-9

Updated

April 2012

Molecular Weight

57.11

Molecular Formula

C3H7N

Synonyms

2-Propen-1-amine (9CI)
2-Propenamine
3-Aminopropene
3-Aminopropylene
Monoallylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg/20S rinse severeAEHLAU 1,343,1960
skin /rabbit 500 mg/24H severeAEHLAU 1,343,1960

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat2500 ng/kgGISAAA 48(1),80,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 320 mg/m3TPKVAL 14,80,1975
inhalation/man lowest published toxic concentration: 2500 ppb/5MEye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
AEHLAU 1,343,1960
inhalation/rat lethal concentration (50 percent kill): 177 ppm/8HOlfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea
AEHLAU 1,343,1960
intraperitoneal/mouse lethal dose (50 percent kill): 49 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AEHLAU 1,343,1960
intraperitoneal/rat lowest published lethal dose: 37500 µg/kgFATOAO 31,238,1968
oral/mammal (species unspecified) lethal dose (50 percent kill): 78300 µg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 57 mg/kgAEHLAU 1,343,1960
oral/rat lethal dose (50 percent kill): 102 mg/kg85GMAT -,17,1982
skin/rabbit lethal dose (50 percent kill): 35 mg/kgSkin: After topical application: Primary irritation

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AEHLAU 1,343,1960
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 783 mg/kgTPKVAL 14,80,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 ppm/7H/50D- intermittentCardiac: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 1,343,1960
oral/rabbit lowest published toxic dose: 4500 µg/kg/26W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 48(1),80,1983
oral/rat lowest published toxic dose: 700 mg/kg/20D- intermittentVascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 72,95,2003
oral/rat lowest published toxic dose: 1400 mg/kg/20D- intermittentVascular: Effect on gills and gill functions

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 66,9,2002
oral/rat lowest published toxic dose: 1 gm/kg/11D- intermittentCardiac: Changes in coronary arteries

Cardiac: Other changes

Vascular: Structural changes in vessels
TXAPA9 103,288,1990
oral/rat lowest published toxic dose: 6240 mg/kg/15W- continuousCardiac: Cardiomyopathy including infarction

Cardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 50,581,1979
unreported route/rat lowest published toxic dose: 700 mg/kg/20D- intermittentVascular: Structural changes in vesselsTOXID9 66,95,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXCYAC 44,129,1987

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (5 mg/m3);KZW 6 ppm (14 mg/m3), skin, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (4.7 mg/m3), skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (5 mg/m3), skin, NOV2011
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (5 mg/m3);short term exposure limit 6 ppm (14 mg/m3), Skin, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code T0127; Number of Industries 1; Total Number of Facilities 13; Number of Occupations 2; Total Number of Employees Exposed 27

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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