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Registry of Toxic Effects of Chemical Substances (RTECS)

Adipic acid, dibutyl ester

RTECS #

AV0900000

CAS #

105-99-7

Updated

April 2012

Molecular Weight

258.40

Molecular Formula

C14H26O4

Synonyms

3PS
Butyl adipate
Cetiol B
Dibutyl adipate
Dibutyl adipinate
Dibutyl hexanedioate
Dibutylester kyseliny adipove (Czech)
Di-n-butyl adipate
Experimental tick repellent 3
Experimental tick repellent 3PS
Hexanedioic acid, dibutyl ester
Unitolate B

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 1049 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JPMSAE 62,1596,1973
intraperitoneal/rat 1748 mg/kg (5-15D pregnant)Reproductive: Other developmental abnormalitiesJPMSAE 62,1596,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >17 mg/m3/2HGISAAA 55(6),86,1990
inhalation/rat Lethal concentration: >17 mg/m3/4HGISAAA 55(6),86,1990
intraperitoneal/rat lethal dose (50 percent kill): 5244 µL/kgJPMSAE 62,1596,1973
oral/mouse lethal dose (50 percent kill): 16890 mg/kgBlood: Other changesGISAAA 55(6),86,1990
oral/rat lethal dose (50 percent kill): 12900 mg/kg28ZEAL 5,72,1976
skin/rabbit lethal dose (50 percent kill): 20 mL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rabbit lowest published toxic dose: 30 mL/kg/6W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJACTDZ 15,295,1996

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 15,295,1996
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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