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Adipic acid, dibutyl ester

RTECS #: AV0900000

CAS #: 105-99-7

UPDATE: February 2006 MW: 258.40 MF: C14H26O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3PS
  2. Butyl adipate
  3. Cetiol B
  4. Di - n - butyl adipate
  5. Dibutyl adipate
  6. Dibutyl adipinate
  1. Dibutylester kyseliny adipove (Czech)
  2. Dibutyl hexanedioate
  3. Experimental tick repellent 3
  4. Experimental tick repellent 3PS
  5. Hexanedioic acid, dibutyl ester
  6. Unitolate B


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,049 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JPMSAE 62,1596,1973
intraperitoneal
rat 		lowest published toxic dose: 1,748 mg/kg (5-15 day pregnant) Reproductive: Other developmental abnormalities JPMSAE 62,1596,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >17 mg/m3/2 hour N/R GISAAA 55(6),86,1990
inhalation
rat 		lethal concentration : >17 mg/m3/4 hour N/R GISAAA 55(6),86,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 5,244 µL/kg N/R JPMSAE 62,1596,1973
oral
mouse 		lethal dose (50 percent kill): 16,890 mg/kg Blood: Other changes GISAAA 55(6),86,1990
oral
rat 		lethal dose (50 percent kill): 12,900 mg/kg N/R 28ZEAL 5,72,1976
skin
rabbit 		lethal dose (50 percent kill): 20 mL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lowest published toxic dose: 30 mL/kg/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JACTDZ 15,295,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JACTDZ 15,295,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used as a plasticizer

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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