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Registry of Toxic Effects of Chemical Substances (RTECS)

Adipic acid, bis(2-ethylhexyl) ester

RTECS #

AU9700000

CAS #

103-23-1; 39393-67-4; 63637-48-9; 70147-21-6

Updated

July 2012

Molecular Weight

370.64

Molecular Formula

C22H42O4

Synonyms

Adipol 2EH
ADO (lubricating oil)
BEHA
Bis(2-ethylhexyl) adipate
Bis-(2-ethylhexyl)ester kyseliny adipove (Czech)
Bisoflex DOA
Crodamol DOA
Di(2-ethylhexyl) adipate
Di(2-ethylhexyl)adipate
Di-2-ethylhexyl adipate
Dioctyl adipate
DOA
Effomoll DOA
Ergoplast ADDO
Flexol A 26
Hatcol 2908
Hexanedioic acid, bis(2-ethylhexyl) ester (9CI)
Hexanedioic acid, dioctyl ester
Kemester 5652
Kodaflex DOA
Lankroflex DOA
Mollan S
Monoplex DOA
Morflex 310
NCI-C54386
Octyl adipate
Plastomoll DOA
PX-238
Reomol DOA
Rucoflex Plasticizer DOA
Sansocizer DOA
Sicol 250
Staflex DOA
Truflex DOA
Uniflex DOA
Vestinol OA
Wickenol 158
Witamol 320

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster400 mg/LEMMUEG 10(Suppl 10),1,1987
Dominant Lethal Testintraperitoneal/mouse1000 mg/kgTXAPA9 32,566,1975
other mutation test systemsoral/mouse2 gm/kgMUREAV 343,157,1995
phage inhibition capacity/Escherichia coli25 µg/wellMUREAV 260,349,1991
Unscheduled DNA Synthesisoral/rat378 µmol/kgCRNGDP 8,1433,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 15 gm/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JPMSAE 62,1596,1973
intraperitoneal/rat 30 gm/kg (5-15D pregnant)Reproductive: Other developmental abnormalitiesJPMSAE 62,1596,1973
oral/rat 18 gm/kg (7-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)REPTED 17,163,2003
oral/rat 14.4 gm/kg (7-21D preg/3D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)REPTED 17,163,2003
oral/rat 13.6 gm/kg (7-23D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
REPTED 17,163,2003
oral/rat 30.4 gm/kg (7-23D preg/21D after birth)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 17,163,2003
oral/rat 11.2 gm/kg (7-21D preg/13D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)REPTED 17,163,2003
oral/rat 26000 mg/kg (18D prior to copulation/0-7D pregnant)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JTSCDR 34,SP101,2009
oral/rat 50000 mg/kg (17D prior to copulation/0-7D pregnant)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JTSCDR 34,SP101,2009
oral/rat 50000 mg/kg (17D prior to copulation/0-7D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)JTSCDR 34,SP101,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1038 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-212,1981
oral/mouse toxic dose: 2163 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-212,1981
oral/mouse toxic dose: 1048 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 65,271,1986
oral/mouse lowest published toxic dose: 2163000 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-185927
oral/mouse lowest published toxic dose: 1038240 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-185927

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 5000 mg/kgBFUUA* -,153,1997
intraperitoneal/rabbit lethal dose (50 percent kill): 38000 mg/kgEye: Lacrimation

Eye: Conjunctiva irritation
BFUUA* -,153,1997
intraperitoneal/rat lethal dose (50 percent kill): 46000 mg/kgBFUUA* -,153,1997
intraperitoneal/rat lethal dose (50 percent kill): >50 mL/kgJPMSAE 62,1596,1973
intravenous/rabbit lethal dose (50 percent kill): 540 mg/kgBFUUA* -,153,1997
intravenous/rat lethal dose (50 percent kill): 900 mg/kgBFUUA* -,153,1997
oral/guinea pig lethal dose (50 percent kill): 12900 mg/kgBFUUA* -,153,1997
oral/mammal (species unspecified) lethal dose (50 percent kill): 15 gm/kgIPSTB3 3,93,1976
oral/mouse lethal dose (50 percent kill): 15000 mg/kgBFUUA* -,153,1997
oral/rat lethal dose (50 percent kill): 7392 mg/kgBFUUA* -,153,1997
skin/rabbit lethal dose (50 percent kill): 16 mL/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 8410 mg/kg/24HBFUUA* -,153,1997

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 168 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-212,1981
oral/mouse lowest published toxic dose: 280 gm/kg/13W- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 123,217,1997
oral/mouse lowest published toxic dose: 500 mg/kg/5D- continuousLiver: Changes in liver weight

Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Lipids including transport
BFUUA* -,153,1997
oral/rat lowest published toxic dose: 500 mg/kg/5D- continuousLiver: Changes in liver weight

Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Lipids including transport
BFUUA* -,153,1997
oral/rat lowest published toxic dose: 8.45 gm/kg/14D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ATSUDG 12,274,1988
oral/rat lowest published toxic dose: 18000 mg/kg/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 17,163,2003
oral/rat lowest published toxic dose: 52500 mg/kg/5W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 21,253,2006
oral/rat lowest published toxic dose: 5600 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightARTODN 80,181,2006
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes
ARTODN 80,181,2006
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight
ARTODN 80,181,2006
oral/rat lowest published toxic dose: 8913.52 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
REPTED 22,411,2006
oral/rat lowest published toxic dose: 43963.36 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
REPTED 22,411,2006
oral/rat lowest published toxic dose: 56000 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 14000 mg/kg/2W- intermittentLiver: Changes in liver weightJTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 28000 mg/kg/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in ovarian weight
JTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 5600 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 28000 mg/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes
JTSCDR 34,SP101,2009
oral/rat lowest published toxic dose: 25200 mg/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982
oral/rat lowest published toxic dose: 191 gm/kg/13W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 123,217,1997

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 77,564,2000
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTSCDR 34,SP1,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80276; Number of Industries 15; Total Number of Facilities 524; Number of Occupations 21; Total Number of Employees Exposed 15636; Total Number of Female Employees Exposed 3628
National Occupational Hazard Survey 1974Hazard Code 80276; Number of Industries 19; Total Number of Facilities 534; Number of Occupations 31; Total Number of Employees Exposed 11847

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8917
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat
On EPA IRIS database
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