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Registry of Toxic Effects of Chemical Substances (RTECS)

Adipic acid

RTECS #

AU8400000

CAS #

124-04-9

Updated

September 201

Molecular Weight

146.16

Molecular Formula

C6H10O4

Synonyms

1,4-Butanedicarboxylic acid
1,6-Hexanedioic acid
Acifloctin
Acinetten
Adilactetten
Adipic acid (ACGIH)
Adipinic acid
Hexanedioic acid
Kyselina adipova (Czech)
Molten adipic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,315,1986
eye /rabbit 10 mg mildHPV199 -,-,2001
skin /rabbit 0.25 gm mildHPV199 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >7700 mg/m3/4HHPV199 -,-,2001
intraperitoneal/rat lethal dose (50 percent kill): 275 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Blood: Hemorrhage
JAFCAU 5,759,1957
intravenous/mouse lethal dose (50 percent kill): 680 mg/kgBehavioral: Convulsions or effect on seizure threshold

Blood: Hemorrhage
JAFCAU 5,759,1957
oral/mouse lethal dose (50 percent kill): 1900 mg/kgGastrointestinal: Other changesJAFCAU 5,759,1957
oral/mouse lethal dose (50 percent kill): 1900 mg/kgGastrointestinal: Other changes

Blood: Hemorrhage
HPV199 -,-,2001
oral/rabbit lethal dose (50 percent kill): >11 gm/kgGISAAA 48(9),72,1983
oral/rat lethal dose (50 percent kill): 5050 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV199 -,-,2001
oral/rat lethal dose (50 percent kill): >11 gm/kgGISAAA 48(9),72,1983
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)
HPV199 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 140 gm/kg/5W- intermittentGastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAONAU 40,1,1967

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 4 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84427; Number of Industries 54; Total Number of Facilities 6259; Number of Occupations 66; Total Number of Employees Exposed 140635; Total Number of Female Employees Exposed 77996
National Occupational Hazard Survey 1974Hazard Code 84427; Number of Industries 21; Total Number of Facilities 1068; Number of Occupations 42; Total Number of Employees Exposed 14846

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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