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Adipic acid

RTECS #: AU8400000

CAS #: 124-04-9


UPDATE: February 2009 MW: 146.16 MF: C6H10O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,4 - Butanedicarboxylic acid
  2. 1,6 - Hexanedioic acid
  3. Acifloctin
  4. Acinetten
  5. Adilactetten
  1. Adipic acid (ACGIH)
  2. Adipinic acid
  3. Hexanedioic acid
  4. Kyselina adipova (Czech)
  5. Molten adipic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,315,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 275 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Blood: Hemorrhage
JAFCAU 5,759,1957
intravenous
mouse
lethal dose (50 percent kill): 680 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Hemorrhage
JAFCAU 5,759,1957
oral
mouse
lethal dose (50 percent kill): 1,900 mg/kg Gastrointestinal: Other changes JAFCAU 5,759,1957
oral
rat
lethal dose (50 percent kill): >11 gm/kg N/R GISAAA 48(9),72,1983
oral
rabbit
lethal dose (50 percent kill): >11 gm/kg N/R GISAAA 48(9),72,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 140 gm/kg/5 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAONAU 40,1,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 4 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84427;
Number of Industries 21;
Total Number of Facilities 1,068;
Number of Occupations 42;
Total Number of Employees Exposed 14,846
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84427;
Number of Industries 54;
Total Number of Facilities 6,259;
Number of Occupations 66;
Total Number of Employees Exposed 140,635;
Total Number of Female Employees Exposed 77,996


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make NYLON 66, esters for plasticizers and as food additive
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used to make NYLON 66, esters for plasticizers and as food additive

Top 50 chemical production: 1.75 billions lbs in 1992, 1.70 billions in 1991

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ADIPIC ACID), SRC, 3/81

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Primary Irritant

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