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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylic acid, 2-ethylhexyl ester

RTECS #

AT0855000

CAS #

103-11-7; 78733-32-1; 84948-57-2; 93460-77-6

Updated

July 2013

Molecular Weight

184.31

Molecular Formula

C11H20O2

Synonyms

1-Hexanol, 2-ethyl-, acrylate
2-Ethylhexyl 2-propenoate
2-Ethylhexyl acrylate
2-Ethylhexylester kyseliny akrylove (Czech)
2-Propenoic acid, 2-ethylhexyl ester (9CI)
Octyl acrylate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg severeAJOPAA 29,1363,1946
eye /rabbit 500 mg/24H mild85JCAE -,372,1986
skin /rabbit 20 mg/24H moderate85JCAE -,372,1986
skin /rabbit 500 mg open irritation test mildUCDS** 11/3/1971
skin /rabbit 10 mg/24H open irritation test severeAMIHBC 4,119,1951

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellsother cell types/mouse70 µg/LEPASR* #FYI-OTS-1284-0367

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 187 gm/kg/78W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JTEHD6 16,55,1985
skin/mouse toxic dose: 240 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 8EHQ-1079-0262

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): >2500 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): >450 mg/m3Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 56(12),19,1991
inhalation/mouse Lowest published lethal concentration: 600 mg/m3Behavioral: ExcitementGTPZAB 26(9),52,1982
inhalation/rat lowest published toxic concentration: 6.2 gm/m3/6HLiver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other
TXCYAC 65,209,1990
intraperitoneal/mouse lethal dose (50 percent kill): 1326 mg/kgJDREAF 51,526,1972
intraperitoneal/rat lethal dose (50 percent kill): 1670 mg/kgAMPMAR 36,58,1975
oral/mouse lethal dose (50 percent kill): 4400 mg/kgBehavioral: ExcitementGTPZAB 26(9),52,1982
oral/mouse lethal dose (50 percent kill): 4400 mg/kgGTPRZ* -,52,1982
oral/rabbit Lethal dose: >4 mL/kgNTIS** OTS0520808
oral/rat lethal dose (50 percent kill): 6700 mg/kgGISAAA -,16,1993
oral/rat lethal dose (50 percent kill): 6500 µL/kgUCDS** 11/3/1971
skin/rabbit lethal dose (50 percent kill): 8480 µL/kgAMIHBC 4,119,1951
skin/rat Lethal dose: >12 gm/kgPJPPAA 32,223,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 103 mg/m3/19W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GTPZAB 26(9),52,1982
inhalation/rat lowest published toxic concentration: 1 mg/m3/24H/17W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 56(12),19,1991
oral/rat lowest published toxic dose: 4020 mg/kg/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 58(3),16,1993
oral/rat lowest published toxic dose: 1785 mg/kg/26W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 58(3),16,1993
oral/rat lowest published toxic dose: 810 mg/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA -,16,1993
oral/rat lowest published toxic dose: 2680 mg/kg/20D- intermittentBehavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA -,16,1993
oral/rat lowest published toxic dose: 900 mg/kg/60D- intermittentBehavioral: Change in psychophysiological tests

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA -,16,1993
oral/rat lowest published toxic dose: 360 mg/kg/120D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA -,16,1993
oral/rat lowest published toxic dose: 450 mg/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
oral/rat lowest published toxic dose: 270 mg/kg/90D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
oral/rat lowest published toxic dose: 450 mg/kg/150D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
oral/rat lowest published toxic dose: 547.5 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
skin/mouse lowest published toxic dose: 23040 mg/kg/2Y- intermittentSkin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 8EHQ-1079-0262
skin/mouse lowest published toxic dose: 20160 mg/kg/84W- intermittentSkin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 88-7800262
skin/mouse lowest published toxic dose: 230400 mg/kg/2Y- intermittentKidney, Ureter, and Bladder: Interstitial nephritis

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 88-7800262

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 60,475,1994
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,475,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 60,475,1994
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWREPTED 22,291,2006

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (82 mg/m3);KZW 10 ppm (82 mg/m3), skin, sen, 2007
Occupational Exposure Limit-GERMANYMAK 5 ppm (38 mg/m3), 2011
Occupational Exposure Limit-POLANDtime-weighted average 35 mg/m3, short term exposure limit 100 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 5 ppm (38 mg/m3), sen, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82082; Number of Industries 10; Total Number of Facilities 592; Number of Occupations 12; Total Number of Employees Exposed 11277; Total Number of Female Employees Exposed 2341
National Occupational Hazard Survey 1974Hazard Code 82082; Number of Industries 17; Total Number of Facilities 1437; Number of Occupations 24; Total Number of Employees Exposed 26428

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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