CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Acrylic acid, 2 - ethylhexyl ester

RTECS #: AT0855000

CAS #: 103-11-7


UPDATE: August 2008 MW: 184.31 MF: C11H20O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Hexanol, 2 - ethyl - , acrylate
  2. 2 - Ethylhexyl acrylate
  3. 2 - Ethylhexylester kyseliny akrylove (Czech)
  1. 2 - Ethylhexyl 2 - propenoate
  2. 2 - Propenoic acid, 2 - ethylhexyl ester (9CI)
  3. Octyl acrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
5 mg severe AJOPAA 29,1363,1946
eye
rabbit
500 mg/24 hour mild 85JCAE -,372,1986
skin
rabbit
20 mg/24 hour moderate 85JCAE -,372,1986
skin
rabbit
500 mg open irritation test mild UCDS** 11/3/1971
skin
rabbit
10 mg/24 hour open irritation test severe AMIHBC 4,119,1951


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in mammalian somatic cells mouse other cell types 70 g/L EPASR* #FYI-OTS-1284-0367


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 187 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JTEHD6 16,55,1985
skin
mouse
toxic dose : 240 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 8EHQ-1079-0262


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): >450 mg/m3 Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 56(12),19,1991
inhalation
mouse
lowest published lethal concentration: 600 mg/m3 Behavioral: Excitement GTPZAB 26(9),52,1982
inhalation
rat
lowest published toxic concentration: 6.2 gm/m3/6 hour Liver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other
TXCYAC 65,209,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 1,326 mg/kg N/R JDREAF 51,526,1972
intraperitoneal
rat
lethal dose (50 percent kill): 1,670 mg/kg N/R AMPMAR 36,58,1975
oral
mouse
lethal dose (50 percent kill): 4,400 mg/kg Behavioral: Excitement GTPZAB 26(9),52,1982
oral
mouse
lethal dose (50 percent kill): 4,400 mg/kg N/R GTPRZ* -,52,1982
oral
rat
lethal dose (50 percent kill): 6,500 L/kg N/R UCDS** 11/3/1971
oral
rat
lethal dose (50 percent kill): 6,700 mg/kg N/R GISAAA -,16,1993
oral
rabbit
lowest published lethal dose: >4 mL/kg N/R NTIS** OTS0520808
skin
rat
lethal dose : >12 gm/kg N/R PJPPAA 32,223,1980
skin
rabbit
lethal dose (50 percent kill): 8,480 L/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 103 mg/m3/19 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GTPZAB 26(9),52,1982
inhalation
rat
lowest published toxic concentration: 1 mg/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 56(12),19,1991
oral
rat
lowest published toxic dose: 4,020 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 58(3),16,1993
oral
rat
lowest published toxic dose: 1,785 mg/kg/26 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 58(3),16,1993
oral
rat
lowest published toxic dose: 810 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 2,680 mg/kg/20 day- intermittent Behavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 900 mg/kg/60 day- intermittent Behavioral: Change in psychophysiological tests

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 360 mg/kg/120 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 450 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 270 mg/kg/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 450 mg/kg/150 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
oral
rat
lowest published toxic dose: 547.5 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA -,16,1993
skin
guinea pig
lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983
skin
mouse
lowest published toxic dose: 21 pph/2 year- intermittent Skin and Appendages: Tumors

Nutritional and Gross Metabolic: Other changes

Tumorigenic: Tumors at site of application
EPASR* FYI-OTS-0887-0367
skin
mouse
lowest published toxic dose: 23,040 mg/kg/2 year- intermittent Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 8EHQ-1079-0262
skin
mouse
lowest published toxic dose: 20,160 mg/kg/84 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 88-7800262
skin
mouse
lowest published toxic dose: 230,400 mg/kg/2 year- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
EPASR* 88-7800262


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 60,475,1994
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,475,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,475,1994
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
REPTED 22,291,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 82 mg/m3 (10 ppm), JAN 2006
Occupational Exposure Limit - POLAND time-weighted average 35 mg/m3, short term exposure limit 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (38 mg/m3),KZG- week 5 ppm (38 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82082;
Number of Industries 17;
Total Number of Facilities 1,437;
Number of Occupations 24;
Total Number of Employees Exposed 26,428
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82082;
Number of Industries 10;
Total Number of Facilities 592;
Number of Occupations 12;
Total Number of Employees Exposed 11,277;
Total Number of Female Employees Exposed 2,341


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of emulsion polymers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPRZ* Gigiena truda i professional'nye zabolevaniia. (Moskva Izdatelstvo Meditsina. Continued by:Meditsina truda i promyshlennaia ekologiia) V.1- 1953-1992
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in production of emulsion polymers

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

ALT CAS #: 78733-32-1
ALT CAS #: 84948-57-2
ALT CAS #: 93460-77-6
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us