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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylic acid, 2-hydroxyethyl ester

RTECS #

AT1750000

CAS #

818-61-1

Updated

October 2012

Molecular Weight

116.13

Molecular Formula

C5H8O3

Synonyms

2-(Acryloyloxy)ethanol
2-Hydroxyethyl acrylate
2-Hydroxyethylester kyseliny akrylove (Czech)
2-Propenoic acid, 2-hydroxyethyl ester (9CI)
beta-Hydroxyethyl acrylate
Bisomer 2HEA
Ethylene glycol, acrylate
Ethylene glycol, monoacrylate
Hydroxyethyl acrylate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg severeUCDS** 3/23/1973
eye /rabbit 20 mg/24H moderate85JCAE -,666,1986
skin /human 0.1%/48HCODEDG 57,21,2007
skin /rabbit 500 mg open irritation test moderateUCDS** 3/23/1973
skin /rabbit 10 mg/24H open irritation test mildAMIHBC 4,119,1951

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/mouse15 mg/LMUTAEX 4,381,1989
micronucleus testlymphocyte/mouse18 mg/LMUTAEX 4,381,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 5 ppm (6-20D pregnant)Reproductive: Other effects on femaleTOSCF2 48,240,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jpcInhibitor Concentration Low: 5 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 280,135,2011
In Vitro/jpcInhibitor Concentration Low: 1 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTXCYAC 280,135,2011
inhalation/rat Lowest published lethal concentration: 500 ppm/4HAMIHBC 4,119,1951
oral/mouse lethal dose (50 percent kill): 300 mg/kgEye: Ptosis

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Alteration in gastric secretion
GTPZAB 24(4),56,1980
oral/rat lethal dose (50 percent kill): 548 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NTIS** OTS0555795
skin/rabbit lethal dose (50 percent kill): 298 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0555795

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 38500 µg/m3/9W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 24(4),56,1980
inhalation/rat lowest published toxic concentration: 38500 µg/m3/9W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Endocrine: Other changes
GTPZAB 24(4),56,1980
inhalation/rat lowest published toxic concentration: 24 mg/m3/6H/2Y- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Skin and Appendages: Other: Hair
NTIS** OTS0555544
intraperitoneal/rat lowest published toxic dose: 3900 mg/kg/13W- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
FAATDF 18,343,1992

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,141,1975

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (5 mg/m3), skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (5 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (5 mg/m3);short term exposure limit 2 ppm (10 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.24 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1326; Number of Industries 4; Total Number of Facilities 107; Number of Occupations 11; Total Number of Employees Exposed 2370; Total Number of Female Employees Exposed 354
National Occupational Hazard Survey 1974Hazard Code A1326; Number of Industries 1; Total Number of Facilities 63; Number of Occupations 6; Total Number of Employees Exposed 1845

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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