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Acrylic acid, 2 - hydroxyethyl ester

RTECS #: AT1750000

CAS #: 818-61-1

UPDATE: May 2008 MW: 116.13 MF: C5H8O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - (Acryloyloxy) ethanol
  2. 2 - Hydroxyethyl acrylate
  3. 2 - Hydroxyethylester kyseliny akrylove (Czech)
  4. 2 - Propenoic acid, 2 - hydroxyethyl ester (9CI)
  5. Bisomer 2HEA
  1. Ethylene glycol, acrylate
  2. Ethylene glycol, monoacrylate
  3. Hydroxyethyl acrylate
  4. beta - Hydroxyethyl acrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 3/23/1973
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,666,1986
skin
rabbit 		500 mg open irritation test moderate UCDS** 3/23/1973
skin
rabbit 		10 mg/24 hour open irritation test mild AMIHBC 4,119,1951


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse lymphocyte 15 mg/L MUTAEX 4,381,1989
micronucleus test mouse lymphocyte 18 mg/L MUTAEX 4,381,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 ppm (6-20 day pregnant) Reproductive: Other effects on female TOSCF2 48,240,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 500 ppm/4 hour N/R AMIHBC 4,119,1951
oral
mouse 		lethal dose (50 percent kill): 300 mg/kg Eye: Ptosis

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Alteration in gastric secretion 		GTPZAB 24(4),56,1980
oral
rat 		lethal dose (50 percent kill): 548 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		NTIS** OTS0555795
skin
rabbit 		lethal dose (50 percent kill): 298 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0555795


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 38,500 µg/m3/9 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 24(4),56,1980
inhalation
rat 		lowest published toxic concentration: 38,500 µg/m3/9 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Endocrine: Other changes 		GTPZAB 24(4),56,1980
inhalation
rat 		lowest published toxic concentration: 24 mg/m3/6 hour/2 year- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Skin and Appendages: Other: Hair 		NTIS** OTS0555544
intraperitoneal
rat 		lowest published toxic dose: 3,900 mg/kg/13 week- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease 		FAATDF 18,343,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.24 mg/m3, 2003
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (5 mg/m3);
short term exposure limit 2 ppm (10 mg/m3), Skin, Sen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1326;
Number of Industries 1;
Total Number of Facilities 63;
Number of Occupations 6;
Total Number of Employees Exposed 1,845
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1326;
Number of Industries 4;
Total Number of Facilities 107;
Number of Occupations 11;
Total Number of Employees Exposed 2,370;
Total Number of Female Employees Exposed 354


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of plastics and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in production of plastics and resins

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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