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Acrylic acid, hexamethylene ester

RTECS #: AT1430000

CAS #: 13048-33-4

UPDATE: August 2003 MW: 226.30 MF: C12H18O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,6 - Hexamethylene diacrylate
  2. 1,6 - Hexanediol diacrylate
  3. 2 - Propenoic acid, 1,6 - hexanediyl ester
  4. C 716
  5. Hexaneglycol diarcylate
  6. Kayarad HDDA
  7. NK Ester A HD
  1. Photomer 4017
  2. SR 238
  3. Sartomer 238
  4. Sartomer SR 238
  5. Setalux UV 2243
  6. Viscoat 230


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		0.1%/24 hour CODEDG 5,178,1979
skin
rabbit 		500 mg/24 hour severe JTEHD6 19,149,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		NTIS** OTS0571218


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 760 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia 		NTIS** OTS0571329
oral
rat 		lethal dose (50 percent kill): 5 gm/kg N/R JTEHD6 19,149,1986
skin
rabbit 		lethal dose (50 percent kill): 3,600 µL/kg N/R JTEHD6 19,149,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983
skin
rabbit 		lowest published toxic dose: 3 gm/kg/2 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0555406


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3645;
Number of Industries 6;
Total Number of Facilities 525;
Number of Occupations 8;
Total Number of Employees Exposed 7,874;
Total Number of Female Employees Exposed 1,281


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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