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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylamide, N-(hydroxymethyl)-

RTECS #

AS3600000

CAS #

924-42-5; 90456-67-0

Updated

March 2011

Molecular Weight

101.12

Molecular Formula

C4H7NO2

Synonyms

2-Propenamide, N-(hydroxymethyl)-
Methylolacrylamide
Monomethylolacrylamide
N-(Hydroxymethyl)-2-propenamide
N-(Hydroxymethyl)acrylamide
NCI-C60333
N-Ethanolacrylamide
N-Methanolacrylamide
N-Methylolacrylamide
Uramine T 80

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 3 mg mildHPV308 -,-,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster375 mg/LNTPTR* NTP-TR-352,1989
Cytogenetic Analysisovary/hamster2473 µmol/LMUREAV 608,28,2006
Dominant Lethal Testoral/mouse604.8 mg/kg/1W-continuousEMMUEG 41,111,2003
Dominant Lethal Testoral/mouse1814.4 mg/kg/84D-continuousEMMUEG 41,111,2003
morphological transformfibroblast/mouse0.1 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
sister chromatid exchangeovary/hamster250 mg/LNTPTR* NTP-TR-352,1989
sperm morphologyoral/mouse730 mg/kg/6W-continuousARTODN 59,201,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 4608 mg/kg (16D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductARTODN 47,179,1981
oral/mouse 730 gm/kg (6W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ARTODN 59,201,1986
oral/mouse 730 gm/kg (6W male)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)ARTODN 59,201,1986
oral/mouse 15.6 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NTIS** #PB93-151561
oral/mouse 15.6 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB93-151561
oral/mouse 188.8 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Musculoskeletal systemNTIS** #PB93-151561
oral/mouse 188.8 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB93-151561
oral/mouse 3220 mg/kg (7D pre-21D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Physical
HPV308 -,-,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 25750 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTPTR* NTP-TR-352,1989
oral/mouse lowest published toxic dose: 25750 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB90-226374/AS
oral/mouse lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
NTIS** PB90-226374/AS
oral/mouse lowest published toxic dose: 25750 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV308 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 563 mg/kgBCPCA6 19,2591,1970
oral/mouse lethal dose (50 percent kill): 400 mg/kgHPV308 -,-,2001
oral/rat lowest published toxic dose: 71 mg/kgBlood: Other changesTOXID9 72(Suppl 1),248,2003
oral/rat lowest published toxic dose: 71 mg/kgBlood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 71,164,2003
oral/rat lethal dose (50 percent kill): 400 mg/kgHPV308 -,-,2001
skin/rabbit lowest published lethal dose: 16 gm/kgBehavioral: TremorATDAEI 1,111,1990
skin/rabbit lethal dose (50 percent kill): >16 gm/kgBehavioral: Tremor

Skin: After topical application: Primary irritation
HPV308 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 4688 mg/kg/8W- intermittentRelated to Chronic Data: Changes in testicular weightARTODN 47,179,1981
oral/mouse lowest published toxic dose: 1625 mg/kg/13W- intermittentBehavioral: Ataxia

Liver: Changes in liver weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NTP-TR-352,1989
oral/mouse lowest published toxic dose: 4800 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-352,1989
oral/mouse lowest published toxic dose: 9525.6 mg/kg/12W- continuousBehavioral: Muscle weaknessNTIS** #PB93-151561
oral/mouse lowest published toxic dose: 10973.3 mg/kg/27W- continuousBehavioral: Muscle weaknessNTIS** #PB93-151561
oral/mouse lowest published toxic dose: 19040 mg/kg/34W- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductNTIS** #PB93-151561
oral/mouse lowest published toxic dose: 19 gm/kg/34W- continuousReproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)NTIS** #PB93-151561
oral/mouse lowest published toxic dose: 8330 mg/kg/34W- continuousReproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** #PB93-151561
oral/mouse lowest published toxic dose: 400 mg/kg/2D- continuousBehavioral: Ataxia

Cardiac: Cardiomyopathy including infarction

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV308 -,,2001
oral/mouse lowest published toxic dose: 812.5 mg/kg/13W- continuousRelated to Chronic Data: Changes in testicular weightHPV308 -,,2001
oral/mouse lowest published toxic dose: 3250 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight
HPV308 -,,2001
oral/mouse lowest published toxic dose: 13000 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight
HPV308 -,,2001
oral/mouse lowest published toxic dose: 4672 mg/kg/8W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
HPV308 -,,2001
oral/rat lowest published toxic dose: 1288 mg/kg/28D- continuousBehavioral: Food intake (animal)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV308 -,,2001
oral/rat lowest published toxic dose: 812.5 mg/kg/13W- continuousBehavioral: Muscle weaknessHPV308 -,,2001
oral/rat lowest published toxic dose: 1625 mg/kg/13W- continuousBehavioral: Muscle weakness

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Blood: Hemorrhage
HPV308 -,,2001
oral/rat lowest published toxic dose: 6500 mg/kg/13W- continuousKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV308 -,,2001
oral/rat lowest published toxic dose: 1200 mg/kg/16D- continuousBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV308 -,,2001
oral/rat lowest published toxic dose: 2400 mg/kg/16D- continuousBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV308 -,,2001
oral/rat lowest published toxic dose: 1600 mg/kg/4D- continuousBehavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV308 -,,2001
oral/rat lowest published toxic dose: 8736 mg/kg/27W- continuousBehavioral: Muscle weaknessBJIMAG 27,147,1970
oral/rat lowest published toxic dose: 2400 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-352,1989
oral/rat lowest published toxic dose: 3250 mg/kg/13W- intermittentBehavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NTP-TR-352,1989

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 60,435,1994
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,435,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 60,435,1994
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 705,184,2010

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81901; Number of Industries 5; Total Number of Facilities 117; Number of Occupations 7; Total Number of Employees Exposed 20665; Total Number of Female Employees Exposed 13852
National Occupational Hazard Survey 1974Hazard Code 81901; Number of Industries 7; Total Number of Facilities 154; Number of Occupations 17; Total Number of Employees Exposed 2938

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);no evidence:rat
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000
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