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Acrylamide, N - (hydroxymethyl) -

RTECS #: AS3600000

CAS #: 924-42-5


UPDATE: February 2008 MW: 101.12 MF: C4H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Propenamide, N - (hydroxymethyl) -
  2. Methylolacrylamide
  3. Monomethylolacrylamide
  4. N - (Hydroxymethyl) - 2 - propenamide
  5. N - (Hydroxymethyl) acrylamide
  1. N - Ethanolacrylamide
  2. N - Methanolacrylamide
  3. N - Methylolacrylamide
  4. NCI - C60333
  5. Uramine T 80


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 375 mg/L NTPTR* NTP-TR-352,1989
cytogenetic analysis hamster ovary 2,473 Ámol/L MUREAV 608,28,2006
dominant lethal test oral
mouse
604.8 mg/kg/1 week- continuous EMMUEG 41,111,2003
dominant lethal test oral
mouse
1,814.4 mg/kg/84 day- continuous EMMUEG 41,111,2003
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 250 mg/L NTPTR* NTP-TR-352,1989
sperm morphology oral
mouse
730 mg/kg/6 week- continuous ARTODN 59,201,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 4,608 mg/kg (16 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARTODN 47,179,1981
oral
mouse
lowest published toxic dose: 730 gm/kg (6 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ARTODN 59,201,1986
oral
mouse
lowest published toxic dose: 730 gm/kg (6 week male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) ARTODN 59,201,1986
oral
mouse
lowest published toxic dose: 15.6 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 15.6 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 188.8 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 188.8 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB93-151561


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 25,750 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTPTR* NTP-TR-352,1989
oral
mouse
lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB90-226374/AS
oral
mouse
lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
NTIS** PB90-226374/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 563 mg/kg N/R BCPCA6 19,2591,1970
oral
mouse
lethal dose (50 percent kill): 420 mg/kg N/R 37ASAA 1,306,1978
oral
rat
lethal dose (50 percent kill): 474 mg/kg N/R NEZAAQ 34,183,1979
oral
rat
lowest published toxic dose: 71 mg/kg Blood: Other changes TOXID9 72(Suppl 1),248,2003
oral
rat
lowest published toxic dose: 71 mg/kg Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 71,164,2003
skin
rabbit
lowest published lethal dose: 16 gm/kg Behavioral: Tremor ATDAEI 1,111,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 4,688 mg/kg/8 week- intermittent Related to Chronic Data: Changes in testicular weight ARTODN 47,179,1981
oral
mouse
lowest published toxic dose: 1,625 mg/kg/13 week- intermittent Behavioral: Ataxia

Liver: Changes in liver weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NTP-TR-352,1989
oral
mouse
lowest published toxic dose: 4,800 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-352,1989
oral
mouse
lowest published toxic dose: 9,525.6 mg/kg/12 week- continuous Behavioral: Muscle weakness NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 10,973.3 mg/kg/27 week- continuous Behavioral: Muscle weakness NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 19,040 mg/kg/34 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 19 gm/kg/34 week- continuous Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB93-151561
oral
mouse
lowest published toxic dose: 8,330 mg/kg/34 week- continuous Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** #PB93-151561
oral
rat
lowest published toxic dose: 8,736 mg/kg/27 week- continuous Behavioral: Muscle weakness BJIMAG 27,147,1970
oral
rat
lowest published toxic dose: 2,400 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-352,1989
oral
rat
lowest published toxic dose: 3,250 mg/kg/13 week- intermittent Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NTP-TR-352,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 60,435,1994
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,435,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,435,1994
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81901;
Number of Industries 7;
Total Number of Facilities 154;
Number of Occupations 17;
Total Number of Employees Exposed 2,938
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81901;
Number of Industries 5;
Total Number of Facilities 117;
Number of Occupations 7;
Total Number of Employees Exposed 20,665;
Total Number of Female Employees Exposed 13,852


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a cross linkable monomer for VINYL ACETATE, acrylic systems
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);no evidence:rat
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a cross linkable monomer for VINYL ACETATE, acrylic systems

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 90456-67-0
Click Here for Additional Information about RTECS

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