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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetyl chloride, dichloro-

RTECS #

AO6650000

CAS #

79-36-7

Updated

July 2011

Molecular Weight

147.38

Molecular Formula

C2HCl3O

Synonyms

2,2-Dichloroacetyl chloride
alpha,alpha-Dichloroacetyl chloride
Chlorid kyseliny dichloroctove (Czech)
Chlorure de dichloracetyle (French)
Dichloracetyl chloride
Dichloroethanoyl chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg open irritation test severeAMIHBC 4,119,1951
eye /rabbit 1% severeHPV200 -,-,2004
skin /rabbit 2 mg/24H severe85JCAE -,571,1986
skin /rabbit 1%HPV200 -,-,2004
skin /rabbit 2 mg severeHPV200 -,-,2004

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)EMMUEG 19(Suppl 21),2,1992

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 ppm/30D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV200 -,-,2004
subcutaneous/mouse lowest published toxic dose: 2 mg/kg/80W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CNREA8 43,159,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 34 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HHPV200 -,-,2004
oral/rat lethal dose (50 percent kill): 2460 mg/kgHPV200 -,-,2004
oral/rat lowest published lethal dose: 1000 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Gastritis
HPV200 -,-,2004
skin/rabbit lethal dose (50 percent kill): 650 µL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 354 mg/kg/6W- intermittentImmunological Including Allergic: Autoimmune (multiple organ involvement)TOXID9 44,186,2005
intraperitoneal/mouse lowest published toxic dose: 206 mg/kg/4W- intermittentImmunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 60,140,2001
intraperitoneal/mouse lowest published toxic dose: 294.76 mg/kg/5W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 216,248,2006
intraperitoneal/mouse lowest published toxic dose: 353.7 mg/kg/6W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Autoimmune (multiple organ involvement)
TXAPA9 216,248,2006

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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