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Acetyl chloride, dichloro -

RTECS #: AO6650000

CAS #: 79-36-7


UPDATE: November 2007 MW: 147.38 MF: C2HCl3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2,2 - Dichloroacetyl chloride
  2. Chlorid kyseliny dichloroctove (Czech)
  3. Chlorure de dichloracetyle (French)
  1. Dichloracetyl chloride
  2. Dichloroethanoyl chloride
  3. alpha,alpha - Dichloroacetyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 g open irritation test severe AMIHBC 4,119,1951
skin
rabbit
2 mg/24 hour severe 85JCAE -,571,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) EMMUEG 19(Suppl 21),2,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 2 mg/kg/80 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CNREA8 43,159,1983


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 2,000 ppm/4 hour N/R AMIHBC 4,119,1951
oral
rat
lethal dose (50 percent kill): 2,460 mg/kg N/R AMIHBC 4,119,1951
skin
rabbit
lethal dose (50 percent kill): 650 L/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 354 mg/kg/6 week- intermittent Immunological Including Allergic: Autoimmune (multiple organ involvement) TOXID9 44,186,2005
intraperitoneal
mouse
lowest published toxic dose: 206 mg/kg/4 week- intermittent Immunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 60,140,2001
intraperitoneal
mouse
lowest published toxic dose: 294.76 mg/kg/5 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 216,248,2006
intraperitoneal
mouse
lowest published toxic dose: 353.7 mg/kg/6 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Autoimmune (multiple organ involvement)
TXAPA9 216,248,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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