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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Acetotoluidide, 2-chloro-6'-ethyl-N-(2-methoxy-1-methylethyl)-

RTECS #

AN3430000

CAS #

51218-45-2; 63150-68-5; 94449-58-8

Updated

October 2010

Molecular Weight

283.83

Molecular Formula

C15H22ClNO2

Synonyms

2-Aethyl-6-methyl-N-(1-methyl-2-methoxyaethyl)-chloracetanilid (German)
2-Chloro-6'-ethyl-N-(2-methoxy-1-methylethyl)acet-o-toluidide
2-Chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide
2-Ethyl-6-methyl-1-N-(2-methoxy-1-methylethyl)chloroacetanilide
2-Etylo-6-metylo-N-(1'-metylo-2'-metoksyetylo)chloroacetanilid (Polish)
Acetamide, 2-chloro-N-(6-ethyl-o-tolyl)-N-(2-methoxy-1-methylethyl)-
alpha-Chlor-6'-aethyl-N-(2-methoxy-1-methylaethyl)-acet-o-toluidin (German)
alpha-Chloro-2'-ethyl-6'-methyl-N-(1-methyl-2-methoxyethyl)-acetanilide
CGA-24705
Codal
Cotoran multi
Dual
Dual 720EC
Dual Triple
Metachlore
Metelilachlor
Metolachlor
Ontrack 8E

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildNNGADV 14,103,1989
skin /rabbit 334 mg open irritation test mildCIGET* -,-,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human100 µg/LMUREAV 281,295,1992
gene conversion and mitotic recombination/Saccharomyes cerevisiae1 µg/plateMUREAV 136,233,1984
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)MUREAV 136,233,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NNGADV 14,103,1989
unreported route/mammal (species unspecified) 76 mg/kg (multigenerations)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)FEREAC 64,11787,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >1750 mg/m3/4HLITRC* TR-78-0310
intraperitoneal/mouse lethal dose (50 percent kill): 410 mg/kgNNGADV 14,103,1989
intraperitoneal/rat lethal dose (50 percent kill): 620 mg/kgNNGADV 14,103,1989
intraperitoneal/rat lowest published toxic dose: 738 mg/kgBiochemical: Metabolism (intermediary): OtherTOXID9 1,54,2001
oral/duck lethal dose (50 percent kill): >2510 mg/kgFMCHA2 -,C203,1991
oral/mouse lethal dose (50 percent kill): 1150 mg/kgNNGADV 14,103,1989
oral/rat lethal dose (50 percent kill): 2200 mg/kgNNGADV 14,103,1989
skin/rabbit lethal dose (50 percent kill): >10 gm/kgLITRC* TR-78-0310
skin/rat lethal dose (50 percent kill): 3170 mg/kgMSNRD5 18,341,1979
subcutaneous/mouse lethal dose (50 percent kill): 2400 mg/kgNNGADV 14,103,1989
subcutaneous/rat lethal dose (50 percent kill): >9 gm/kgNNGADV 14,103,1989
unreported route/rat lethal dose (50 percent kill): 3170 mg/kgAGKYAU (5),138,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 4550 mg/kg/26W- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NNGADV 14,103,1989
oral/mouse lowest published toxic dose: 263 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNNGADV 14,103,1989
oral/rat lowest published toxic dose: 5460 mg/kg/13W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 14,103,1989
oral/rat lowest published toxic dose: 131 gm/kg/2Y- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 14,103,1989
oral/rat lowest published toxic dose: 109200 mg/kg/104W- continuousLiver: TumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 23310 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 68,15945,2003
unreported route/rat lowest published toxic dose: 567.7 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 66,321,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFEREAC 72,44439,2007
TOXICOLOGY REVIEWFEREAC 73,29456,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWFEREAC 73,52607,2008
TOXICOLOGY REVIEWFEREAC 73,53732,2008
TOXICOLOGY REVIEWFEREAC 74,30487,2009
TOXICOLOGY REVIEWFEREAC 74,48408,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989

Status in Federal Agencies

OrganizationReference
On EPA IRIS database
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