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o - Acetotoluidide, 2 - chloro - 6' - ethyl - N - (2 - methoxy - 1 - methylethyl) -

RTECS #: AN3430000

CAS #: 51218-45-2


UPDATE: May 2009 MW: 283.83 MF: C15H22ClNO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Aethyl - 6 - methyl - N - (1 - methyl - 2 - methoxyaethyl) - chloracetanilid (German)
  2. 2 - Chloro - 6' - ethyl - N - (2 - methoxy - 1 - methylethyl) acet - o - toluidide
  3. 2 - Chloro - N - (2 - ethyl - 6 - methylphenyl) - N - (2 - methoxy - 1 - methylethyl) acetamide
  4. 2 - Ethyl - 6 - methyl - 1 - N - (2 - methoxy - 1 - methylethyl) chloroacetanilide
  5. 2 - Etylo - 6 - metylo - N - (1' - metylo - 2' - metoksyetylo) chloroacetanilid (Polish)
  6. Acetamide, 2 - chloro - N - (6 - ethyl - o - tolyl) - N - (2 - methoxy - 1 - methylethyl) -
  7. CGA - 24705
  8. Codal
  9. Cotoran multi
  1. Dual
  2. Dual 720EC
  3. Dual Triple
  4. Metachlore
  5. Metelilachlor
  6. Metolachlor
  7. Ontrack 8E
  8. alpha - Chlor - 6' - aethyl - N - (2 - methoxy - 1 - methylaethyl) - acet - o - toluidin (German)
  9. alpha - Chloro - 2' - ethyl - 6' - methyl - N - (1 - methyl - 2 - methoxyethyl) - acetanilide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild NNGADV 14,103,1989
skin
rabbit
334 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 g/L MUREAV 281,295,1992
mutation in microorganisms Salmonella typhimurium 10 g/plate (-enzymatic activation step) MUREAV 136,233,1984
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 g/plate MUREAV 136,233,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NNGADV 14,103,1989
unreported route
mammal (species unspecified)
lowest published toxic dose: 76 mg/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) FEREAC 64,11787,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >1,750 mg/m3/4 hour N/R LITRC* TR-78-0310
intraperitoneal
mouse
lethal dose (50 percent kill): 410 mg/kg N/R NNGADV 14,103,1989
intraperitoneal
rat
lethal dose (50 percent kill): 620 mg/kg N/R NNGADV 14,103,1989
intraperitoneal
rat
lowest published toxic dose: 738 mg/kg Biochemical: Metabolism (intermediary): Other TOXID9 1,54,2001
oral
duck
lethal dose (50 percent kill): >2,510 mg/kg N/R FMCHA2 -,C203,1991
oral
mouse
lethal dose (50 percent kill): 1,150 mg/kg N/R NNGADV 14,103,1989
oral
rat
lethal dose (50 percent kill): 2,200 mg/kg N/R NNGADV 14,103,1989
subcutaneous
mouse
lethal dose (50 percent kill): 2,400 mg/kg N/R NNGADV 14,103,1989
subcutaneous
rat
lethal dose (50 percent kill): >9 gm/kg N/R NNGADV 14,103,1989
skin
rat
lethal dose (50 percent kill): 3,170 mg/kg N/R MSNRD5 18,341,1979
skin
rabbit
lethal dose (50 percent kill): >10 gm/kg N/R LITRC* TR-78-0310
unreported route
rat
lethal dose (50 percent kill): 3,170 mg/kg N/R AGKYAU (5),138,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 4,550 mg/kg/26 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NNGADV 14,103,1989
oral
mouse
lowest published toxic dose: 263 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NNGADV 14,103,1989
oral
rat
lowest published toxic dose: 5,460 mg/kg/13 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 14,103,1989
oral
rat
lowest published toxic dose: 131 gm/kg/2 year- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 14,103,1989
oral
rat
lowest published toxic dose: 109,200 mg/kg/104 week- continuous Liver: Tumors HBPTO* 1,814,2001
oral
rat
lowest published toxic dose: 23,310 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 68,15945,2003
unreported route
rat
lowest published toxic dose: 567.7 mg/kg/4 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 66,321,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FEREAC 72,44439,2007
TOXICOLOGY REVIEW
FEREAC 73,29456,2008
TOXICOLOGY REVIEW
FEREAC 72,44439,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
HUTOX* -,551,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

AGKYAU Agrokhimiya. Agricultural Chemistry. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1964-
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HUTOX*
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
LITRC* Literature Research Co., Translation. (Annandale, VA)
MSNRD5 Materialy Sesji Naukowej Instytutu Ochrony Roslin (Poznan). Materials of the Scientific Session of the Institute of Plant Protection. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) History not known.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a herbicide for weed control in corn

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 63150-68-5
ALT CAS #: 94449-58-8
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