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Acetophenone, 2 - chloro -

RTECS #: AM6300000

CAS #: 532-27-4


UPDATE: May 2009 MW: 154.60 MF: C8H7ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Chloroacetophenone
  2. 2 - Chloro - 1 - phenylethanone
  3. 2 - Chloroacetophenone
  4. CN
  5. Chemical mace
  6. Chloromethyl phenyl ketone
  7. Ethanone, 2 - chloro - 1 - phenyl -
  1. Mace (lacrimator)
  2. NCI - C55107
  3. Phenacyl chloride
  4. Phenylchloromethylketone
  5. alpha - Chloroacetophenone
  6. alpha - Chloroacetophenone (ACGIH:OSHA)
  7. omega - Chloroacetophenone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1 mg mild TXAPA9 17,295,1970
eye
rabbit
3 mg severe TXAPA9 17,295,1970
eye
rabbit
2% rinse mild ARTODN 34,183,1975
eye
rabbit
1% VCVGK* -,463,1994
skin
guinea pig
12%/6 hour open irritation test moderate ARTODN 40,75,1978
skin
human
0.5 mg/1 hour moderate CODEDG 86,150,1972
skin
rat
12%/6 hour open irritation test moderate ARTODN 40,75,1978
skin
rabbit
5 mg/24 hour mild TXAPA9 17,295,1970
skin
rabbit
12%/6 hour open irritation test moderate ARTODN 40,75,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 3 mg/L NTPTR* NTP-TR-379,1990
DNA damage rat liver 10 Ámol/L MUREAV 368,59,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2 mg/m3/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-379,1990
skin
mouse
lowest published toxic dose: 2,400 mg/kg/27 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
BJCAAI 7,482,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
lowest published toxic dose: 5 pph Eye: Corneal damage VCVGK* -,463,1994
inhalation
guinea pig
lowest published lethal concentration: 490 mg/m3/30 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation
human
lowest published lethal concentration: 159 mg/m3/20 minute N/R 34ZIAG -,163,1969
inhalation
human
lowest published toxic concentration: 93 mg/m3/3 minute Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 23,199,1962
inhalation
human
lowest published toxic concentration: 20 mg/m3 Eye: Other eye effects

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
BJIMAG 29,298,1972
inhalation
human
lowest published toxic concentration: 0.5 mg/m3/10S Eye: Conjunctiva irritation VCVGK* -,463,1994
inhalation
mouse
lethal concentration (50 percent kill): 59 mg/m3 N/R GISAAA 58(10),4,1993
inhalation
rat
lowest published lethal concentration: 417 mg/m3/15 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation
rabbit
lowest published lethal concentration: 465 mg/m3/20 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
intraperitoneal
guinea pig
lethal dose (50 percent kill): 17 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
intraperitoneal
mouse
lethal dose (50 percent kill): 60 mg/kg N/R NTIS** AD837-111
intraperitoneal
rat
lethal dose (50 percent kill): 36 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
intravenous
mouse
lethal dose (50 percent kill): 81 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
intravenous
mouse
lethal dose (50 percent kill): 81 mg/kg N/R ENTOX* ,706,2005
intravenous
rat
lethal dose (50 percent kill): 41 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
intravenous
rabbit
lethal dose (50 percent kill): 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
oral
guinea pig
lethal dose (50 percent kill): 158 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
oral
mouse
lethal dose (50 percent kill): 139 mg/kg N/R NTIS** AD837-111
oral
rat
lethal dose (50 percent kill): 50 mg/kg N/R TXAPA9 17,295,1970
oral
rabbit
lethal dose (50 percent kill): 118 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
skin
guinea pig
lethal dose (50 percent kill): >1 gm/kg N/R NTIS** OTS0556684


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 10 mg/m3/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-379,1990
inhalation
mouse
lowest published toxic concentration: 87.6 mg/m3/15 minute/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Lung, Thorax, or Respiration: Other changes

Endocrine: Hyperglycemia
JAPTO* 14,411,1994
inhalation
rat
lowest published toxic concentration: 19 mg/m3/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-379,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CPEMM* 3,239,2002
TOXICOLOGY REVIEW
ENTOX* -,626,2005
TOXICOLOGY REVIEW
ENTOX* -,706,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 ppm (0.3 mg/m3) DTLVS* 3,48,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.32 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.32 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.05 ppm (0.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.3 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.05 ppm (0.3 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 ppm (0.3 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.32 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.3 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 ppm (0.32 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-CHLOROACETOPHENONE-air 10 hour time-weighted average 0.05 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4754;
Number of Industries 1;
Total Number of Facilities 35;
Number of Occupations 4;
Total Number of Employees Exposed 2,294;
Total Number of Female Employees Exposed 1,412


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CPEMM* Clinical Pediatric Emergency Medicine (Philadelphia, PA : W.B. Saunders Co.)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an industrial chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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