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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetophenone

RTECS #

AM5250000

CAS #

98-86-2

Updated

September 201

Molecular Weight

120.16

Molecular Formula

C8H8O

Synonyms

1-Phenylethanone
Acetofenon (Czech)
Acetophenon
Acetophenone (ACGIH)
Acetylbenzene
Benzene, acetyl-
Benzoyl methide
Ethanone, 1-phenyl- (9CI)
Hypnon
Hypnone
Ketone, methyl phenyl
Methyl phenyl ketone
Phenyl methyl ketone
RCRA waste number U004
USAF EK-496

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg severeAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944
skin /rabbit 515 mg open irritation test mildUCDS** 12/27/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster600 mg/LESKHA5 (103),64,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 32 gm/kg (4W male/10D preg-3D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 72,76,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 2184.5 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 1200 mg/m3GTPZAB 32(10),25,1988
inhalation/mouse lethal concentration (50 percent kill): 1200 mg/m3/4HEye: Conjunctiva irritation

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,461,1994
inhalation/rat Lethal concentration: >210 ppm/8HUCDS** 12/27/1971
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD277-689
oral/mammal (species unspecified) lethal dose (50 percent kill): 2700 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 740 mg/kgGTPZAB 26(8),53,1982
oral/mouse lethal dose (50 percent kill): 1250 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
oral/rat lethal dose (50 percent kill): 2650 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
oral/rat lethal dose (50 percent kill): 815 mg/kgGTPZAB 26(8),53,1982
skin/guinea pig lethal dose (50 percent kill): >20 mL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 15900 µL/kgUCDS** 12/27/1971
subcutaneous/mouse lowest published lethal dose: 330 mg/kgBehavioral: Somnolence (general depressed activity)HDTU** -,-,1933
unreported route/guinea pig lethal dose (50 percent kill): 2000 mg/kgVCVGK* -,461,1994
unreported route/mouse lethal dose (50 percent kill): 533 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
unreported route/mouse lowest published lethal dose: 510 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
unreported route/rabbit lethal dose (50 percent kill): 1760 mg/kgVCVGK* -,461,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.07 mg/m3/75D- intermittentBehavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,461,1994
inhalation/rabbit lowest published toxic concentration: 15 mg/m3/167D- intermittentBehavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,461,1994
inhalation/rat lowest published toxic concentration: 77 mg/m3/106D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,461,1994
inhalation/rat lowest published toxic concentration: 15 mg/m3/167D- intermittentBehavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,461,1994
oral/rabbit lowest published toxic dose: 45.5 mg/kg/13W- intermittentBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,461,1994
oral/rabbit lowest published toxic dose: 4.55 mg/kg/13W- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,461,1994
oral/rat lowest published toxic dose: 21 gm/kg/28D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests
TOXID9 72,76,2003
oral/rat lowest published toxic dose: 21 gm/kg/28D- intermittentBehavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,76,2003
oral/rat lowest published toxic dose: 6.3 gm/kg/28D- intermittentGastrointestinal: Changes in structure or function of salivary glandsTOXID9 72,76,2003
oral/rat lowest published toxic dose: 18000 mg/kg/60D- intermittentBehavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
VCVGK* -,461,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 144,383,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (50 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (49 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 50 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (49 mg/m3), NOV2011
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (49 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 49 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80265; Number of Industries 48; Total Number of Facilities 4433; Number of Occupations 61; Total Number of Employees Exposed 78624; Total Number of Female Employees Exposed 31148

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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