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Acetophenone

RTECS #: AM5250000

CAS #: 98-86-2


UPDATE: February 2009 MW: 120.16 MF: C8H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Phenylethanone
  2. Acetofenon (Czech)
  3. Acetophenon
  4. Acetophenone (ACGIH)
  5. Acetylbenzene
  6. Benzene, acetyl -
  7. Benzoyl methide
  8. Ethanone, 1 - phenyl - (9CI)
  1. Hypnon
  2. Hypnone
  3. Ketone, methyl phenyl
  4. Methyl phenyl ketone
  5. Phenyl methyl ketone
  6. RCRA waste number U004
  7. USAF EK - 496


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
750 g severe AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit
515 mg open irritation test mild UCDS** 12/27/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 600 mg/L ESKHA5 (103),64,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 32 gm/kg (4 week male/10 day pregnant-3 day after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 72,76,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 1,200 mg/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse
lethal concentration (50 percent kill): 1,200 mg/m3/4 hour Eye: Conjunctiva irritation

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,461,1994
inhalation
rat
lethal concentration : >210 ppm/8 hour N/R UCDS** 12/27/1971
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD277-689
oral
mammal (species unspecified)
lethal dose (50 percent kill): 2,700 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 740 mg/kg N/R GTPZAB 26(8),53,1982
oral
mouse
lethal dose (50 percent kill): 1,250 mg/kg Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
oral
rat
lethal dose (50 percent kill): 815 mg/kg N/R GTPZAB 26(8),53,1982
oral
rat
lethal dose (50 percent kill): 2,650 mg/kg Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
subcutaneous
mouse
lowest published lethal dose: 330 mg/kg Behavioral: Somnolence (general depressed activity) HDTU** -,-,1933
skin
guinea pig
lethal dose (50 percent kill): >20 mL/kg N/R JIHTAB 26,269,1944
skin
mouse
lowest published lethal dose: 100 pph/4 hour N/R VCVGK* -,461,1994
skin
rabbit
lethal dose (50 percent kill): 15,900 L/kg N/R UCDS** 12/27/1971
unreported route
guinea pig
lethal dose (50 percent kill): 2,000 mg/kg N/R VCVGK* -,461,1994
unreported route
mouse
lethal dose (50 percent kill): 533 mg/kg Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
unreported route
mouse
lowest published lethal dose: 510 mg/kg Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,461,1994
unreported route
rabbit
lethal dose (50 percent kill): 1,760 mg/kg N/R VCVGK* -,461,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.7 mg/m3/75 day- intermittent Behavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,461,1994
inhalation
rat
lowest published toxic concentration: 77 mg/m3/106 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,461,1994
inhalation
rat
lowest published toxic concentration: 15 mg/m3/167 day- intermittent Behavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,461,1994
inhalation
rabbit
lowest published toxic concentration: 15 mg/m3/167 day- intermittent Behavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,461,1994
oral
rat
lowest published toxic dose: 18,000 mg/kg/60 day- intermittent Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
VCVGK* -,461,1994
oral
rat
lowest published toxic dose: 21 gm/kg/28 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests
TOXID9 72,76,2003
oral
rat
lowest published toxic dose: 21 gm/kg/28 day- intermittent Behavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,76,2003
oral
rat
lowest published toxic dose: 6.3 gm/kg/28 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands TOXID9 72,76,2003
oral
rabbit
lowest published toxic dose: 45.5 mg/kg/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,461,1994
oral
rabbit
lowest published toxic dose: 4.55 mg/kg/13 week- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,461,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 144,383,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (50 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (49 mg/m3), OCT 2002
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 49 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80265;
Number of Industries 48;
Total Number of Facilities 4,433;
Number of Occupations 61;
Total Number of Employees Exposed 78,624;
Total Number of Female Employees Exposed 31,148


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a hypnotic agent, in perfumes, organic synthesis, and in polymerization of olefins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a hypnotic agent, in perfumes, organic synthesis, and in polymerization of olefins

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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