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Acetonitrile, chloro -

RTECS #: AL8225000

CAS #: 107-14-2


UPDATE: May 2008 MW: 75.50 MF: C2H2ClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. REVIEWS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Chloroacetonitrile
  2. Chloracetonitrile
  3. Chloroacetonitrile
  4. Chloromethyl cyanide
  1. Monochloroacetonitrile
  2. Monochloromethyl cyanide
  3. USAF KF - 5
  4. alpha - Chloroacetonitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,907,1986
skin
rabbit
14 mg/24 hour open irritation test mild AIHAAP 23,95,1962
skin
rabbit
500 mg/24 hour mild 85JCAE -,907,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human lymphocyte 15 Ámol/L NTIS** PB84-246230
DNA damage human HeLa cell 10 Ámol/L/30 minute EMMUEG 36,52,2000
unscheduled DNA synthesis oral
rat
115 mg/kg TOXID9 13,220,1993
mutation in microorganisms Salmonella typhimurium 30 mg/L (+enzymatic activation step) MUREAV 341,289,1995
mutation in microorganisms Salmonella typhimurium 0.13 mmol/L/72 hour (-enzymatic activation step) EMMUEG 36,52,2000
micronucleus test multiple
non-mammalian species
1,250 Ág/L MUREAV 341,289,1995
sister chromatid exchange hamster ovary 79,100 nmol/L FAATDF 5,1065,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 325 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TOXID9 44,220,2005
oral
mouse
lowest published toxic dose: 175 mg/kg (6-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
TOXID9 78,377,2004
oral
mouse
lowest published toxic dose: 325 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Central nervous system
TOXID9 78,377,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 4,800 mg/kg/2 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
FAATDF 5,1065,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 250 ppm/4 hour N/R AIHAAP 23,95,1962
intraperitoneal
mouse
lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
oral
mouse
lethal dose (50 percent kill): 139 mg/kg N/R ARTODN 55,47,1984
oral
rat
lethal dose (50 percent kill): 220 mg/kg N/R AIHAAP 23,95,1962
skin
rabbit
lethal dose (50 percent kill): 71 ÁL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 52,269,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1325,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 52,269,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1325,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1325,1999
TOXICOLOGY REVIEW
MUREAV 636,242,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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