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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetonitrile, chloro-

RTECS #

AL8225000

CAS #

107-14-2

Updated

October 2012

Molecular Weight

75.50

Molecular Formula

C2H2ClN

Synonyms

2-Chloroacetonitrile
alpha-Chloroacetonitrile
Chloracetonitrile
Chloroacetonitrile
Chloromethyl cyanide
Monochloroacetonitrile
Monochloromethyl cyanide
USAF KF-5

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,907,1986
skin /rabbit 14 mg/24H open irritation test mildAIHAAP 23,95,1962
skin /rabbit 500 mg/24H mild85JCAE -,907,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human15 µmol/LNTIS** PB84-246230
DNA DamageHeLa cell/human10 µmol/L/30MEMMUEG 36,52,2000
micronucleus testmultiple/non-mammalian species1250 µg/LMUREAV 341,289,1995
mutation in microorganisms/Salmonella typhimurium30 mg/L (+enzymatic activation step)MUREAV 341,289,1995
mutation in microorganisms/Salmonella typhimurium0.13 mmol/L/72H (-enzymatic activation step)EMMUEG 36,52,2000
sister chromatid exchangeovary/hamster79100 nmol/LFAATDF 5,1065,1985
Unscheduled DNA Synthesisoral/rat115 mg/kgTOXID9 13,220,1993

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 325 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TOXID9 44,220,2005
oral/mouse 175 mg/kg (6-12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
TOXID9 78,377,2004
oral/mouse 325 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Central nervous system
TOXID9 78,377,2004
oral/mouse 325 mg/kg (6-18D pregnant)Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TOLED5 190,123,2009
oral/mouse 650 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus
TOLED5 190,123,2009
oral/mouse 162.5 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TIHEEC 24,511,2008
oral/mouse 325 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TIHEEC 24,511,2008
oral/mouse 650 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TIHEEC 24,511,2008
oral/mouse 650 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTIHEEC 24,511,2008

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 4800 mg/kg/2W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
FAATDF 5,1065,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 250 ppm/4HAIHAAP 23,95,1962
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 139 mg/kgARTODN 55,47,1984
oral/rat lethal dose (50 percent kill): 220 mg/kgAIHAAP 23,95,1962
skin/rabbit lethal dose (50 percent kill): 71 µL/kgAIHAAP 23,95,1962

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 52,269,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,1325,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 52,269,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1325,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1325,1999
TOXICOLOGY REVIEWMUREAV 636,242,2007

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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