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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetoacetic acid, methyl ester

RTECS #

AK5775000

CAS #

105-45-3

Updated

April 2012

Molecular Weight

116.13

Molecular Formula

C5H8O3

Synonyms

3-Oxobutanoic acid methyl ester
Acetoacetic methyl ester
Butanoic acid, 3-oxo-, methyl ester (9CI)
Methyl 3-oxobutanoate
Methyl 3-oxobutyrate
Methyl acetylacetate
Methyl acetylacetonate
Methylacetoacetate
Methylester kyseliny acetoctove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 2 mg severeAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation testJIHTAB 30,63,1948
skin /rabbit 500 mg/24H mildFCTXAV 16,815,1978

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002
Cytogenetic Analysislung/hamster1200 mg/L (+enzymatic activation step)HPV299 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): >2 gm/kgHPV295 -,-,2003
oral/rat lethal dose (50 percent kill): 2.58 gm/kgBehavioral: Coma

Blood: Hemorrhage
HPV295 -,-,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84355; Number of Industries 2; Total Number of Facilities 30; Number of Occupations 5; Total Number of Employees Exposed 1872; Total Number of Female Employees Exposed 336
National Occupational Hazard Survey 1974Hazard Code 84355; Number of Industries 1; Total Number of Facilities 23; Number of Occupations 1; Total Number of Employees Exposed 270

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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