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Acetoacetic acid, ethyl ester

RTECS #: AK5250000

CAS #: 141-97-9


UPDATE: February 2006 MW: 130.16 MF: C6H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - Oxobutanoic acid ethyl ester
  2. Acetoacetic ester
  3. Acetoctan ethylnaty (Czech)
  4. Active acetyl acetate
  5. Butanoic acid, 3 - oxo - , ethyl ester
  6. Diacetic ether
  7. EAA
  1. Ethyl 3 - oxobutanoate
  2. Ethyl 3 - oxobutyrate
  3. Ethyl acetoacetate
  4. Ethyl acetyl acetate
  5. Ethyl acetylacetonate
  6. Ethylacetacetat (Czech)
  7. Ethylester kyseliny acetoctove (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe AJOPAA 29,1363,1946
eye
rabbit
100 mg/24 hour moderate 85JCAE -,729,1986
skin
rabbit
510 mg open irritation test mild UCDS** 3/12/1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 21 mg/disc OIGZDE 34,267,1985
mutation in microorganisms Escherichia coli 200 g/plate (-enzymatic activation step) OIGZDE 34,267,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 5,105 mg/kg N/R JPMSAE 60,1810,1971
oral
rat
lethal dose (50 percent kill): 3,980 mg/kg N/R JIHTAB 31,60,1949
skin
rabbit
lethal dose : >20 mL/kg N/R UCDS** 3/12/1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84283;
Number of Industries 2;
Total Number of Facilities 49;
Number of Occupations 16;
Total Number of Employees Exposed 2,518
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84283;
Number of Industries 10;
Total Number of Facilities 678;
Number of Occupations 9;
Total Number of Employees Exposed 6,334;
Total Number of Female Employees Exposed 1,863


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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