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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetoacetic acid, ethyl ester

RTECS #

AK5250000

CAS #

141-97-9

Updated

July 2013

Molecular Weight

130.16

Molecular Formula

C6H10O3

Synonyms

3-Oxobutanoic acid ethyl ester
Acetoacetic ester
Acetoctan ethylnaty (Czech)
Active acetyl acetate
Butanoic acid, 3-oxo-, ethyl ester
Diacetic ether
EAA
Ethyl 3-oxobutanoate
Ethyl 3-oxobutyrate
Ethyl acetoacetate
Ethyl acetyl acetate
Ethyl acetylacetonate
Ethylacetacetat (Czech)
Ethylester kyseliny acetoctove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAJOPAA 29,1363,1946
eye /rabbit 100 mg/24H moderate85JCAE -,729,1986
skin /rabbit 510 mg open irritation test mildUCDS** 3/12/1969

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis21 mg/discOIGZDE 34,267,1985
mutation in microorganisms/Escherichia coli200 µg/plate (-enzymatic activation step)OIGZDE 34,267,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 31 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 2116.8 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
oral/mouse lethal dose (50 percent kill): 5105 mg/kgJPMSAE 60,1810,1971
oral/rat lethal dose (50 percent kill): 3980 mg/kgJIHTAB 31,60,1949
skin/rabbit Lethal dose: >20 mL/kgUCDS** 3/12/1969

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84283; Number of Industries 10; Total Number of Facilities 678; Number of Occupations 9; Total Number of Employees Exposed 6334; Total Number of Female Employees Exposed 1863
National Occupational Hazard Survey 1974Hazard Code 84283; Number of Industries 2; Total Number of Facilities 49; Number of Occupations 16; Total Number of Employees Exposed 2518

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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