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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetin, tri-

RTECS #

AK3675000

CAS #

102-76-1

Updated

July 2013

Molecular Weight

218.23

Molecular Formula

C9H14O6

Synonyms

1,2,3-Propanetriol triacetate
Enzactin
Fungacetin
Glycerin triacetate
Glycerol triacetate
Glyceryl triacetate
Glyped
Kesscoflex TRA
Kodaflex triacetin
Triacetin
Triacetine
Triacetyl glycerine
Vanay

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 116 mgJPETAB 82,377,1944

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 29 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 4361.2 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intramuscular/guinea pig lowest published lethal dose: 1740 mg/kgLung, Thorax, or Respiration: DyspneaJPETAB 76,189,1942
intraperitoneal/mouse lethal dose (50 percent kill): 1400 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Stiffness
FEPRA7 22,368,1963
intraperitoneal/rat lethal dose (50 percent kill): 2100 mg/kgFCTXAV 16,879,1978
intravenous/Dog lethal dose (50 percent kill): 1500 mg/kgFCTXAV 16,879,1978
intravenous/mouse lethal dose (50 percent kill): 1600 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
APSCAX 40,338,1957
intravenous/rabbit lethal dose (50 percent kill): 750 mg/kgFCTXAV 16,879,1978
oral/frog lowest published lethal dose: 150 mg/kgFCTXAV 16,879,1978
oral/mouse lethal dose (50 percent kill): 1100 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Stiffness
FEPRA7 22,368,1963
oral/rat lethal dose (50 percent kill): 3 gm/kgAMIHAB 21,28,1960
subcutaneous/mouse lethal dose (50 percent kill): 2300 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
PSEBAA 46,26,1941
subcutaneous/rat lethal dose (50 percent kill): 2800 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
PSEBAA 46,26,1941

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWIJTOFN 22,1,2003
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 741,32,2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1910; Number of Industries 13; Total Number of Facilities 713; Number of Occupations 21; Total Number of Employees Exposed 18436; Total Number of Female Employees Exposed 4103
National Occupational Hazard Survey 1974Hazard Code M1910; Number of Industries 17; Total Number of Facilities 832; Number of Occupations 25; Total Number of Employees Exposed 11313

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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