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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, trifluoro-

RTECS #

AJ9625000

CAS #

76-05-1

Updated

October 2010

Molecular Weight

114.03

Molecular Formula

C2HF3O2

Synonyms

Kyselina trifluoroctova (Czech)
Perfluoroacetic acid
Trifluoracetic acid
Trifluoroethanoic acid

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1650 mg/kg (10-20D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JJATDK 17,1,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 13500 mg/m3Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 10(3),13,1966
inhalation/rat lethal concentration (50 percent kill): 10 gm/m3Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 10(3),13,1966
intraperitoneal/mouse lowest published lethal dose: 150 mg/kgTXAPA9 15,83,1969
intravenous/mouse lethal dose (50 percent kill): 1200 mg/kgBehavioral: Change in motor activity (specific assay)AMEBA7 46,242,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 mg/m3/4H/22W- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 10(3),13,1966
oral/mouse lowest published toxic dose: 120 mg/kg/10D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
XENOBH 23,761,1993

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 29,1,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83936; Number of Industries 4; Total Number of Facilities 159; Number of Occupations 11; Total Number of Employees Exposed 8046; Total Number of Female Employees Exposed 1731
National Occupational Hazard Survey 1974Hazard Code 83936; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 66

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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