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Acetic acid, (3,5,6 - trichloro - 2 - pyridyloxy) -

RTECS #: AJ9000000

CAS #: 55335-06-3


UPDATE: February 2009 MW: 256.47 MF: C7H4Cl3NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. REFERENCES:

SYNONYMS:

  1. 3,5,6 - Trichloro - 2 - pyridyloxyacetic acid
  2. Crossbow
  3. Dowco 233
  4. Garlon
  1. Grazon ET
  2. Redeem
  3. Triclopyr
  4. Turflon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,550 mg/kg (multigenerations) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FAATDF 4,872,1984
oral
rat
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 4,872,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
duck
lethal dose (50 percent kill): 1,693 mg/kg N/R DOEAAH 35,25,1979
oral
guinea pig
lethal dose (50 percent kill): 310 mg/kg N/R PEMNDP 9,844,1991
oral
mammal (species unspecified)
lethal dose (50 percent kill): 630 mg/kg N/R FEREAC 67,58712,2002
oral
rat
lethal dose (50 percent kill): 630 mg/kg N/R FMCHA2 -,C310,1991
oral
rabbit
lethal dose (50 percent kill): 550 mg/kg N/R PEMNDP 9,844,1991
skin
mammal (species unspecified)
lethal dose (50 percent kill): >2,000 mg/kg N/R FEREAC 67,58712,2002
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,844,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 4,560 mg/kg/228 day- intermittent Liver: Other changes

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,58712,2002
oral
dog
lowest published toxic dose: 4,560 mg/kg/228 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FEREAC 67,58712,2002
oral
rat
lowest published toxic dose: 1,820 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TOXID9 5,1,1985
oral
rat
lowest published toxic dose: 1,800 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FEREAC 67,58712,2002
oral
rat
lowest published toxic dose: 3,000 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 23,165,2008
oral
rat
lowest published toxic dose: 300 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 23,165,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FEREAC 72,41913,2007
TOXICOLOGY REVIEW
FEREAC 72,41913,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as an herbicide

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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