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Acetic acid, propyl ester

RTECS #: AJ3675000

CAS #: 109-60-4


UPDATE: May 2009 MW: 102.15 MF: C5H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Acetoxypropane
  2. 1 - Propyl acetate
  3. Acetate de propyle normal (French)
  4. Acetic acid n - propyl ester
  5. Octan propylu (Polish)
  1. Propyl acetate
  2. Propylester kyseliny octove (Czech)
  3. n - Propyl acetate
  4. n - Propyl acetate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,355,1986
skin
rabbit
500 mg open irritation test mild UCDS** 1/25/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 38 gm/m3/5 hour Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Other changes
AGGHAR 5,1,1933
inhalation
human
lowest published toxic concentration: 1,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R AIHAAP 30,470,1969
intraperitoneal
mouse
lethal dose (50 percent kill): 1,420 mg/kg N/R SCCUR* -,8,1961
oral
mouse
lethal dose (50 percent kill): 8,300 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 9,370 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
FCTXAV 2,327,1964
oral
rabbit
lethal dose (50 percent kill): 6,640 mg/kg N/R IMSUAI 41,31,1972
subcutaneous
cat
lowest published lethal dose: 3 gm/kg Behavioral: Somnolence (general depressed activity) AGGHAR 5,1,1933
subcutaneous
guinea pig
lowest published lethal dose: 3 gm/kg Behavioral: Somnolence (general depressed activity) AGGHAR 5,1,1933
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 1/25/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm;short term exposure limit 250 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMIHAB 21,28,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (840 mg/m3) DTLVS* 3,216,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (840 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (840 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (840 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (840 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (835 mg/m3), short term exposure limit 250 ppm (1040 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (847 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 250 ppm (1055 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (625 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (840 mg/m3), short term exposure limit 250 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.001 mg(Rh)/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 200 ppm (840 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 420 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 840 mg/m3, short term exposure limit 840 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (830 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (840 mg/m3), short term exposure limit 250 ppm (1050 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (840 mg/m3);
short term exposure limit 250 ppm (1050 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 420 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 200 ppm (835 mg/m3), short term exposure limit 250 ppm (1040 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (420 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Rh)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Rh)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (840 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 1000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 100 ppm (400 mg/m3);
short term exposure limit 200 ppm (800 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (420 mg/m3),KZG- week 200 ppm (840 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (840 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (849 mg/m3);
short term exposure limit 250 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm;
short term exposure limit 250 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm;
short term exposure limit 250 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-PROPYL ACETATE-air 10 hour time-weighted average 200 ppm;
short term exposure limit 250 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 63265;
Number of Industries 38;
Total Number of Facilities 1,960;
Number of Occupations 48;
Total Number of Employees Exposed 32,970
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 63265;
Number of Industries 34;
Total Number of Facilities 3,859;
Number of Occupations 42;
Total Number of Employees Exposed 46,856;
Total Number of Female Employees Exposed 11,660


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for resins and plastics in flavoring agents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent for resins and plastics in flavoring agents

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Human Data
   Primary Irritant

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