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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, nitrilotri-

RTECS #

AJ0175000

CAS #

139-13-9; 26627-44-1; 26627-45-2; 80751-51-5

Updated

December 2012

Molecular Weight

191.16

Molecular Formula

C6H9NO6

Synonyms

alpha,alpha',alpha''-Trimethylaminetricarboxylic acid
Aminotriacetic acid
CHEL 300
Complexon I
Glycine, N,N-bis(carboxymethyl)- (9CI)
Hampshire NTA acid
Komplexon I
Kyselina nitrilotrioctova (Czech)
N,N-Bis(carboxymethyl)glycine
NCI-C02766
Nitrilotriacetic acid
Nitrilotris(methylenecarboxylic acid)
NTA
Titriplex I
Triglycine
Triglycollamic acid
Trilon A
Versene NTA acid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1000 mg/L/20H (-enzymatic activation step)EMMUEG 49,439,2008
Cytogenetic Analysislymphocyte/human500 mg/L/44H (-enzymatic activation step)EMMUEG 49,439,2008
DNA Damageother cell types/mouse1.63 mmol/L/4H (-enzymatic activation step)EMMUEG 49,439,2008
DNA Damagekidney/rat0.81 mmol/L/4H (-enzymatic activation step)EMMUEG 49,439,2008
DNA Damageother cell types/rat2 mmol/L/20HTXCYAC 179,115,2002
DNA Damageother cell types/human2 mmol/L/20HTXCYAC 179,115,2002
DNA Damagefibroblast/human15 mmol/L/1HTOLED5 147,35,2004
DNA Damageoral/rat1000 mg/kgEMMUEG 49,439,2008
micronucleus testother cell types/mouse625 mg/L/24H (-enzymatic activation step)EMMUEG 49,439,2008
micronucleus testlymphocyte/mouse1250 mg/L/24H (-enzymatic activation step)EMMUEG 49,439,2008
micronucleus testother cell types/mouse1.63 mmol/L/24H (-enzymatic activation step)EMMUEG 49,439,2008
morphological transformembryo/hamster2 gm/LMUREAV 356,85,1996
specific locus testother cell types/mouse444.4 mg/L/24H (-enzymatic activation step)EMMUEG 49,439,2008

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 832 gm/kg/66W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-6,1977
oral/rat lowest published toxic dose: 430 gm/kg/75W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-6,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 325 mg/kgCRTXB2 20,83,1989
oral/mouse lethal dose (50 percent kill): 3160 mg/kgNCILB* NCI-E-C-72-3252,1973
oral/rat lethal dose (50 percent kill): 1100 mg/kgACIEAY 14,94,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 41292 mg/kg/7W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)FCTOD7 20,925,1982
oral/rat lowest published toxic dose: 29439 µg/kg/4W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Ca
FCTXAV 17,137,1979

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 48,181,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,385,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 48,181,1990
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,385,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 73,385,1999
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWTXCYAC 196,1,2004
TOXICOLOGY REVIEWMUREAV 627,59,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 723,121,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80058; Number of Industries 24; Total Number of Facilities 1082; Number of Occupations 23; Total Number of Employees Exposed 25216; Total Number of Female Employees Exposed 7169
National Occupational Hazard Survey 1974Hazard Code 80058; Number of Industries 31; Total Number of Facilities 1115; Number of Occupations 32; Total Number of Employees Exposed 13454

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-6,1977
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen
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