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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, nitrilotri-, trisodium salt, monohydrate

RTECS #

AJ1070000

CAS #

18662-53-8

Updated

December 2012

Molecular Weight

311.16

Molecular Formula

C6H6NO6·3Na·H2O

Synonyms

Glycine, N,N-bis(carboxymethyl)-, trisodium salt, monohydrate
N,N-Bis(carboxymethyl)glycine trisodium salt monohydrate
NCI-C01445
Nitriloacetic acid trisodium salt monohydrate
Nitrilotriacetic acid trisodium salt monohydrate
NTA sodium hydrate
Trisodium nitrilotriacetate monohydrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellsother cell types/human11 µmol/LTOLED5 25,137,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 900 µg/kg (9-14D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 23,222,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 315 gm/kg/75W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-6,1977
oral/rat toxic dose: 876 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
FCTOD7 20,441,1982
oral/rat lowest published toxic dose: 830 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-6,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgNTIS** AD691-490

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 44434 µg/kg/4W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Ca
FCTXAV 17,137,1979
oral/rat lowest published toxic dose: 60988 mg/kg/7W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)FCTOD7 20,925,1982

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 48,181,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,385,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,385,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 73,385,1999
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 682,94,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9062; Number of Industries 25; Total Number of Facilities 1167; Number of Occupations 28; Total Number of Employees Exposed 21592; Total Number of Female Employees Exposed 9232

Status in Federal Agencies

OrganizationReference
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-6,1977
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