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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, 2-methoxy-1-methylethyl ester

RTECS #

AI8925000

CAS #

108-65-6

Updated

July 2013

Molecular Weight

132.18

Molecular Formula

C6H12O3

Synonyms

1-Methoxy-2-acetoxypropane
1-Methoxy-2-propyl acetate
2-Propanol, 1-methoxy-, acetate (9CI)
Dowanol (R) PMA glycol ether acetate
PGMEA
Propylene glycol monomethyl acetate
Propylene glycol monomethyl ether acetate
Propyleneglycol monomethyl ether acetate

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1105 mg/m3/4HBehavioral: Alteration of classical conditioningTOVEFN (2),44,2007
intraperitoneal/mouse lethal dose (50 percent kill): >1500 mg/kgBehavioral: ComaTOVEFN (2),44,2007
intraperitoneal/mouse lethal dose (50 percent kill): 750 mg/kgNTIS** AD691-490
oral/mouse lethal dose (50 percent kill): >5000 mg/kgBehavioral: ComaTOVEFN (2),44,2007
oral/rat lethal dose (50 percent kill): 9000 mg/kgBehavioral: ComaTOVEFN (2),44,2007
oral/rat lethal dose (50 percent kill): 8532 mg/kgDOWCC* MSD-1582
skin/rabbit lethal dose (50 percent kill): >5 gm/kgDOWCC* MSD-1582

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 237 mg/m3/30D- intermittentBehavioral: Alteration of classical conditioningTOVEFN (2),44,2007

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTXB2 30,307,2000

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (369 mg/m3), short term exposure limit 100 ppm (548 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (275 mg/m3);KZW 100 ppm (550 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (275 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 100 ppm (550 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (275 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 275 mg/m3 (50 ppm);short term exposure limit 550 mg/m3 (100 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (270 mg/m3), short term exposure limit 100 ppm (550 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (275 mg/m3), VLE 100 ppm (550 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 50 ppm (270 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 275 mg/m3, short term exposure limit 550 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (275 mg/m3), short term exposure limit 100 ppm (550 mg/m3), skin, NOV2011
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (275 mg/m3); short term exposure limit 100 ppm (550 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (250 mg/m3);short term exposure limit 75 ppm (400 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 50 ppm (275 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 550 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (274 mg/m3);short term exposure limit 100 ppm (548 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9258; Number of Industries 178; Total Number of Facilities 30459; Number of Occupations 109; Total Number of Employees Exposed 345446; Total Number of Female Employees Exposed 40133

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #99
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