CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Acetic acid, 2 - methoxy - 1 - methylethyl ester

RTECS #: AI8925000

CAS #: 108-65-6


UPDATE: May 2009 MW: 132.18 MF: C6H12O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Methoxy - 2 - acetoxypropane
  2. 1 - Methoxy - 2 - propyl acetate
  3. 2 - Propanol, 1 - methoxy - , acetate (9CI)
  4. Dowanol (R) PMA glycol ether acetate
  1. PGMEA
  2. Propylene glycol monomethyl acetate
  3. Propylene glycol monomethyl ether acetate
  4. Propyleneglycol monomethyl ether acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 750 mg/kg N/R NTIS** AD691-490
oral
rat
lethal dose (50 percent kill): 8,532 mg/kg N/R DOWCC* MSD-1582
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R DOWCC* MSD-1582


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CRTXB2 30,307,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (369 mg/m3), short term exposure limit 100 ppm (548 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (275 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 100 ppm (550 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (275 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 50 ppm (275 mg/m3);
short term exposure limit 100 ppm (skin), FEB 2006
Occupational Exposure Limit - FRANCE VME 50 ppm (275 mg/m3), VLE 100 ppm (550 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 270 mg/m3 (50 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 275 mg/m3, short term exposure limit 550 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 550 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (250 mg/m3);
short term exposure limit 75 ppm (400 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (275 mg/m3),KZG- week 50 ppm (275 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (274 mg/m3);
short term exposure limit 100 ppm (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9258;
Number of Industries 178;
Total Number of Facilities 30,459;
Number of Occupations 109;
Total Number of Employees Exposed 345,446;
Total Number of Female Employees Exposed 40,133


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #99


REFERENCES:

CODEN
REFERENCE

CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us