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Acetic acid, mercury (2+) salt

RTECS #: AI8575000

CAS #: 1600-27-7


UPDATE: May 2009 MW: 318.69 MF: C4H6O4Hg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bis (acetyloxy) mercury
  2. Diacetoxymercury
  3. Mercuriacetate
  4. Mercuric acetate
  5. Mercuric diacetate
  1. Mercury (2+) acetate
  2. Mercury (II) acetate
  3. Mercury diacetate
  4. Mercuryl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in mammalian somatic cells hamster ovary 100 nmol/L EMMUEG 27,30,1996
other mutation test systems mouse other cell types 50 mg/L MUREAV 17,93,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
ENVRAL 8,207,1974
intravenous
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis
LSBGAY 10,1341,1971
intravenous
hamster
lowest published toxic dose: 4 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ENVRAL 6,95,1973
intravenous
hamster
lowest published toxic dose: 4 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities ENVRAL 8,207,1974
intravenous
rat
lowest published toxic dose: 3 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ATSUDG 7,382,1984
oral
hamster
lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 8,207,1974
oral
hamster
lowest published toxic dose: 25 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities ENVRAL 8,207,1974
oral
hamster
lowest published toxic dose: 35 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
ENVRAL 8,207,1974
oral
hamster
lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis ENVRAL 8,207,1974
subcutaneous
hamster
lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Body wall
ENVRAL 8,207,1974
subcutaneous
hamster
lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis ENVRAL 8,207,1974
subcutaneous
hamster
lowest published toxic dose: 4 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 8,207,1974
subcutaneous
hamster
lowest published toxic dose: 15 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
BECTA6 25,726,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 6,500 g/kg N/R GTPZAB 25(7),27,1981
intravenous
mouse
lethal dose (50 percent kill): 4,390 g/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
NYKZAU 57,219,1961
oral
mouse
lethal dose (50 percent kill): 23,900 g/kg N/R GISAAA 46(8),12,1981
oral
rat
lethal dose (50 percent kill): 40,900 g/kg N/R GISAAA 46(8),12,1981
subcutaneous
mouse
lowest published lethal dose: 20 mg/kg N/R MOLAAF 73,751,1939
skin
rat
lethal dose (50 percent kill): 570 mg/kg N/R GTPZAB 25(7),27,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 4,246 mg/kg/1 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AMIHBC 2,433,1950


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg(Hg)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 58,239,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 58,239,1993
TOXICOLOGY REVIEW
AJOGAH 126,390,1976
TOXICOLOGY REVIEW
CRTXB2 33,215,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg(Hg)/m3 DTLWS* 3,22,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.003 ppm (0.025 mg(Hg)/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.025 mg(Hg)/m3, Skin, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 mg(Hg)/m3, Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.08 mg(Hg)/m3, short term exposure limit 0.32 mg(Hg)/m3, Skin, SEP2000
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Hg)/m3, MAC(short term exposure limit) 0.15 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.03 mg(Hg)/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Hg)/m3,KZG- week 0.8 mg(Hg)/m3, DEC2006
Occupational Exposure Limit - THAILAND short term exposure limit 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-air ceiling concentration 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83751;
Number of Industries 4;
Total Number of Facilities 109;
Number of Occupations 4;
Total Number of Employees Exposed 856
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83751;
Number of Industries 11;
Total Number of Facilities 320;
Number of Occupations 10;
Total Number of Employees Exposed 6,064;
Total Number of Female Employees Exposed 2,770


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
LSBGAY Life Sciences, Part 2: Biochemistry, General and Molecular Biology. (New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK.
MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie. (Vienna, Austria) V.1-108, 1867-1974. For publisher information, see LROTDW.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 6129-23-3
ALT CAS #: 7619-62-7
ALT CAS #: 19701-15-6
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