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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, mercury(2+) salt

RTECS #

AI8575000

CAS #

1600-27-7; 6129-23-3; 7619-62-7; 19701-15-6

Updated

December 2013

Molecular Weight

318.69

Molecular Formula

C4H6O4·Hg

Synonyms

Bis(acetyloxy)mercury
Diacetoxymercury
Mercuriacetate
Mercuric acetate
Mercuric diacetate
Mercury diacetate
Mercury(2+) acetate
Mercury(II) acetate
Mercuryl acetate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/human0.1 µmol/L/12HMUTAEX 28,515,2013
DNA repairother cell types/human1 µmol/L/12HMUTAEX 28,515,2013
micronucleus testlung/hamster75 µmol/L/6H (+enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster18.8 µmol/L/24H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster37.6 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
mutation in mammalian somatic cellsovary/hamster100 nmol/LEMMUEG 27,30,1996
other mutation test systemsother cell types/mouse50 mg/LMUREAV 17,93,1973

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/hamster 2 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
ENVRAL 8,207,1974
intravenous/rat 3 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ATSUDG 7,382,1984
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis
LSBGAY 10,1341,1971
intravenous/hamster 4 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ENVRAL 6,95,1973
intravenous/hamster 4 mg/kg (8D pregnant)Reproductive: Other developmental abnormalitiesENVRAL 8,207,1974
oral/hamster 8 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ENVRAL 8,207,1974
oral/hamster 25 mg/kg (8D pregnant)Reproductive: Other developmental abnormalitiesENVRAL 8,207,1974
oral/hamster 35 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
ENVRAL 8,207,1974
oral/hamster 50 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: HomeostasisENVRAL 8,207,1974
subcutaneous/hamster 8 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Body wall
ENVRAL 8,207,1974
subcutaneous/hamster 8 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: HomeostasisENVRAL 8,207,1974
subcutaneous/hamster 4 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ENVRAL 8,207,1974
subcutaneous/hamster 15 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
BECTA6 25,726,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 6500 µg/kgGTPZAB 25(7),27,1981
intravenous/mouse lethal dose (50 percent kill): 4390 µg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
NYKZAU 57,219,1961
oral/mouse lethal dose (50 percent kill): 23900 µg/kgGISAAA 46(8),12,1981
oral/rat lethal dose (50 percent kill): 40900 µg/kgGISAAA 46(8),12,1981
skin/rat lethal dose (50 percent kill): 570 mg/kgGTPZAB 25(7),27,1981
subcutaneous/mouse lowest published lethal dose: 20 mg/kgMOLAAF 73,751,1939

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4246 mg/kg/1Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)AMIHBC 2,433,1950

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.025 mg(Hg)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 58,239,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 58,239,1993
TOXICOLOGY REVIEWAJOGAH 126,390,1976
TOXICOLOGY REVIEWCRTXB2 33,215,2003

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.05 mg(Hg)/m3DTLWS* 3,22,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.003 ppm (0.025 mg(Hg)/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.025 mg(Hg)/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCEVME 0.1 mg(Hg)/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Hg)/m3, skin, sen, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.08 mg(Hg)/m3, short term exposure limit 0.32 mg(Hg)/m3, Skin, SEP2000
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg(Hg)/m3, MAC(short term exposure limit) 0.15 mg(Hg)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.03 mg(Hg)/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.02 mg(Hg)/m3, KZG-week 0.16 mg(Hg)/m3, inhal, skin, sen, JAN2011
Occupational Exposure Limit-THAILANDshort term exposure limit 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.05 mg(Hg)/m3, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-airceiling concentration 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83751; Number of Industries 11; Total Number of Facilities 320; Number of Occupations 10; Total Number of Employees Exposed 6064; Total Number of Female Employees Exposed 2770
National Occupational Hazard Survey 1974Hazard Code 83751; Number of Industries 4; Total Number of Facilities 109; Number of Occupations 4; Total Number of Employees Exposed 856

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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