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Acetic acid, isopropyl ester

RTECS #: AI4930000

CAS #: 108-21-4


UPDATE: May 2009 MW: 102.15 MF: C5H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Acetoxypropane
  2. 2 - Propyl acetate
  3. Acetate d'isopropyle (French)
  4. Acetic acid, 1 - methylethyl ester (9CI)
  5. Isopropile (acetato di) (Italian)
  6. Isopropyl (acetate d') (French)
  1. Isopropyl acetate
  2. Isopropyl acetate (ACGIH:OSHA)
  3. Isopropylacetaat (Dutch)
  4. Isopropylacetat (German)
  5. Isopropylester kyseliny octove (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
200 ppm/15 minute N/R JIHTAB 28,262,1946
skin
rabbit
500 mg/24 hour mild 85JCAE -,354,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 200 ppm Lung, Thorax, or Respiration: Other changes AMIHAB 21,28,1960
inhalation
rat
lethal concentration (50 percent kill): 50,600 mg/m3/8 hour N/R AIHAAP 20,364,1959
intraperitoneal
rat
lethal dose : >174 mg/kg N/R JSGRA2 53,572,1992
intravenous
rat
lowest published lethal dose: 174 mg/kg N/R JSGRA2 53,572,1992
oral
rat
lethal dose (50 percent kill): 6,750 mg/kg N/R UCDS** 3/24/1970
oral
rabbit
lethal dose (50 percent kill): 6,946 mg/kg N/R IMSUAI 41,31,1972
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R AMIHBC 10,61,1954
unreported route
human
lowest published toxic concentration: 200 ppm Eye: Conjunctiva irritation JIHTAB 28,262,1946


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 200 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMIHAB 21,28,1960
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 250 ppm (950 mg/m3) DTLVS* 3,141,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1290 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm(424 mg/m3), short term exposure limit 200 ppm(849 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (625 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 250 ppm (950 mg/m3), VLE 300 ppm (1140 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 420 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 840 mg/m3, short term exposure limit 840 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 250 ppm (950 mg/m3), short term exposure limit 310 ppm (1185 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 250 ppm (950 mg/m3);
short term exposure limit 310 ppm (1185 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 250 ppm (1040 mg/m3);
short term exposure limit 310 ppm (1290 mg/m3),JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 250 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 50 mg/m3, short term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (420 mg/m3),KZG- week 200 ppm (840 mg/m3),DEC2006
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 200 ppm (849 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm;
short term exposure limit 200 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm;
short term exposure limit 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40984;
Number of Industries 103;
Total Number of Facilities 10,160;
Number of Occupations 67;
Total Number of Employees Exposed 84,001
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40984;
Number of Industries 85;
Total Number of Facilities 8,643;
Number of Occupations 68;
Total Number of Employees Exposed 159,819;
Total Number of Female Employees Exposed 50,913


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an organic solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl acetate, 1454


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HUTOX*
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as an organic solvent

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Human Data
   Primary Irritant

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