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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, (ethylenedinitrilo)tetra-

RTECS #

AH4025000

CAS #

60-00-4

Updated

July 2013

Molecular Weight

292.28

Molecular Formula

C10H16N2O8

Synonyms

3,6-Diazaoctanedioic acid, 3,6-bis(carboxymethyl)-
Acide ethylenediaminetetracetique (French)
Celon A
Celon ATH
Cheelox
Cheelox BF acid
Chemcolox 340
Clewat TAA
Complexon II
Edathamil
Edetic acid
EDTA
EDTA (chelating agent)
EDTA acid
Endrate
Ethylenediamine-N,N,N',N'-tetraacetic acid
Ethylenediaminetetraacetate
Ethylenediaminetetraacetic acid
Ethylenedinitrilotetraacetic acid
Gluma cleanser
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)- (9CI)
Hamp-ene acid
Havidote
ICRF 185
Komplexon II
Kyselina ethylendiamintetraoctova (Czech)
Metaquest A
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine)
Nervanaid B acid
Nullapon B acid
Nullapon BF acid
Perma kleer 50 acid
Questex 4H
SEQ 100
Sequestrene AA
Sequestric acid
Sequestrol
Tetrine acid
Titriplex
Trilon BS
Trilon BW
Versene acid
Vinkeil 100
Warkeelate acid
YD 30

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse50 mmol/LCISCB7 20,28,1976
Cytogenetic Analysisembryo/hamster500 µmol/L/24HMUREAV 603,111,2006
DNA Damageother cell types/mouse3.25 mmol/L/4H (-enzymatic activation step)EMMUEG 49,439,2008
DNA Damagekidney/rat1.63 mmol/L/4H (-enzymatic activation step)EMMUEG 49,439,2008
DNA Damagelymphocyte/mouse40500 µmol/LMUREAV 203,155,1988
DNA inhibitionkidney/rabbit250 µmol/LECREAL 36,92,1964
DNA inhibitionfibroblast/hamster500 µg/LECREAL 163,191,1986
DNA inhibitionother cell types/rat600 µmol/LREXMAS 192,115,1992
micronucleus testintraperitoneal/mouse186 mg/kgEMMUEG 19,125,1992
micronucleus testoral/mouse15 mg/kgFCTOD7 29,845,1991
micronucleus testoral/rat1400 mg/kg/7D- intermittentARTODN 82,183,2008
mutation in mammalian somatic cellslymphocyte/mouse25200 µmol/LMUTAEX 3,193,1988
sister chromatid exchangeembryo/hamster30 µmol/LSHIGAZ 74,1365,1987
Unscheduled DNA Synthesisembryo/hamster100 µmol/LSHIGAZ 74,1365,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 7632 mg/kg (7-14D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 40,299,1977
oral/rat 7632 mg/kg (7-14D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 40,299,1977
oral/rat 7632 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 40,299,1977
subcutaneous/rat 3 gm/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 40,299,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 315.3 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 50.78 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
intraperitoneal/mouse lethal dose (50 percent kill): 250 mg/kgNTIS** AD691-490
intraperitoneal/rat lethal dose (50 percent kill): 397 mg/kgBehavioral: Convulsions or effect on seizure thresholdAHRTAN 13,295,1962
intraperitoneal/rat lethal dose (50 percent kill): 512.9 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Liver: Other changes
IJTOFN 21,95,2002
intravenous/mouse lethal dose (50 percent kill): 28500 µg/kgJJPAAZ 63,187,1993
oral/mouse lethal dose (50 percent kill): 30 mg/kgFCTOD7 29,845,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 82,183,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWBJMRDK 34,449,2001
TOXICOLOGY REVIEWIJTOFN 21,95,2002
TOXICOLOGY REVIEWENTOX* -,147,2005
TOXICOLOGY REVIEWFEREAC 71,11563,2006
TOXICOLOGY REVIEWMUTAEX 22,161,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,309,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80283; Number of Industries 119; Total Number of Facilities 14680; Number of Occupations 116; Total Number of Employees Exposed 509055; Total Number of Female Employees Exposed 315637
National Occupational Hazard Survey 1974Hazard Code 80283; Number of Industries 122; Total Number of Facilities 12157; Number of Occupations 93; Total Number of Employees Exposed 121906

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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