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Acetic acid, (ethylenedinitrilo) tetra -

RTECS #: AH4025000

CAS #: 60-00-4


UPDATE: November 2008 MW: 292.28 MF: C10H16N2O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3,6 - Diazaoctanedioic acid, 3,6 - bis (carboxymethyl) -
  2. Acide ethylenediaminetetracetique (French)
  3. Celon A
  4. Celon ATH
  5. Cheelox
  6. Cheelox BF acid
  7. Chemcolox 340
  8. Clewat TAA
  9. Complexon II
  10. EDTA
  11. EDTA (chelating agent)
  12. EDTA acid
  13. Edathamil
  14. Edetic acid
  15. Endrate
  16. Ethylenediaminetetraacetate
  17. Ethylenediaminetetraacetic acid
  18. Ethylenediamine - N,N,N',N' - tetraacetic acid
  19. Ethylenedinitrilotetraacetic acid
  20. Gluma cleanser
  21. Glycine, N,N' - 1,2 - ethanediylbis (N - (carboxymethyl) - (9CI)
  22. Hamp - ene acid
  23. Havidote
  1. ICRF 185
  2. Komplexon II
  3. Kyselina ethylendiamintetraoctova (Czech)
  4. Metaquest A
  5. N,N' - 1,2 - Ethanediylbis (N - (carboxymethyl) glycine)
  6. Nervanaid B acid
  7. Nullapon B acid
  8. Nullapon BF acid
  9. Perma kleer 50 acid
  10. Questex 4H
  11. SEQ 100
  12. Sequestrene AA
  13. Sequestric acid
  14. Sequestrol
  15. Tetrine acid
  16. Titriplex
  17. Trilon BS
  18. Trilon BW
  19. Versene acid
  20. Vinkeil 100
  21. Warkeelate acid
  22. YD 30


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster embryo 500 µmol/L/24 hour MUREAV 603,111,2006
cytogenetic analysis intraperitoneal
mouse
50 mmol/L CISCB7 20,28,1976
DNA damage mouse lymphocyte 40,500 µmol/L MUREAV 203,155,1988
DNA inhibition hamster fibroblast 500 µg/L ECREAL 163,191,1986
DNA inhibition rat other cell types 600 µmol/L REXMAS 192,115,1992
DNA inhibition rabbit kidney 250 µmol/L ECREAL 36,92,1964
unscheduled DNA synthesis hamster embryo 100 µmol/L SHIGAZ 74,1365,1987
micronucleus test intraperitoneal
mouse
186 mg/kg EMMUEG 19,125,1992
micronucleus test oral
mouse
15 mg/kg FCTOD7 29,845,1991
mutation in mammalian somatic cells mouse lymphocyte 25,200 µmol/L MUTAEX 3,193,1988
sister chromatid exchange hamster embryo 30 µmol/L SHIGAZ 74,1365,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,632 mg/kg (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 40,299,1977
oral
rat
lowest published toxic dose: 7,632 mg/kg (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 40,299,1977
oral
rat
lowest published toxic dose: 7,632 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 40,299,1977
subcutaneous
rat
lowest published toxic dose: 3 gm/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 40,299,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 250 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat
lethal dose (50 percent kill): 397 mg/kg Behavioral: Convulsions or effect on seizure threshold AHRTAN 13,295,1962
intraperitoneal
rat
lethal dose (50 percent kill): 512.9 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Liver: Other changes
IJTOFN 21,95,2002
intravenous
mouse
lethal dose (50 percent kill): 28,500 µg/kg N/R JJPAAZ 63,187,1993
oral
mouse
lethal dose (50 percent kill): 30 mg/kg N/R FCTOD7 29,845,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BJMRDK 34,449,2001
TOXICOLOGY REVIEW
IJTOFN 21,95,2002
TOXICOLOGY REVIEW
ENTOX* -,147,2005
TOXICOLOGY REVIEW
FEREAC 71,11563,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,309,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80283;
Number of Industries 122;
Total Number of Facilities 12,157;
Number of Occupations 93;
Total Number of Employees Exposed 121,906
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80283;
Number of Industries 119;
Total Number of Facilities 14,680;
Number of Occupations 116;
Total Number of Employees Exposed 509,055;
Total Number of Female Employees Exposed 315,637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as general purpose chelating agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AHRTAN Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial Hygiene and Toxicology. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.7- 1956-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
CISCB7 CIS, Chromosome Information Service. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) No.1- 1961-
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REXMAS Research in Experimental Medicine. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.157- 1972-
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as general purpose chelating agent

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
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   Mutagen
   Reproductive Effector

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