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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, cobalt(2+) salt, tetrahydrate

RTECS #

AG3325000

CAS #

6147-53-1

Updated

September 201

Molecular Weight

249.11

Molecular Formula

C4H6O4·Co·4H2O

Synonyms

Bis(acetato)tetraquacobalt
Cobalt acetate tetrahydrate
Cobalt diacetate tetrahydrate
Cobalt(II) acetate tetrahydrate
Cobaltous acetate tetrahydrate
Octan kobaltnaty (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,21,1972
skin /rabbit 500 mg/24H moderate28ZPAK -,21,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human600 µg/LCYGEDX 12(3),46,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lethal dose (50 percent kill): 28 mg/kgHPV287 -,-,2002
oral/rat lethal dose (50 percent kill): 708 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 20,311,1982
oral/rat lethal dose (50 percent kill): 708 mg/kgLung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
HPV287 -,-,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 52,363,1991

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COBALT METAL, dust and fume-air10H time-weighted average 0.05 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3284; Number of Industries 2; Total Number of Facilities 52; Number of Occupations 3; Total Number of Employees Exposed 6143; Total Number of Female Employees Exposed 629
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