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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, ((4-chloro-o-tolyl)oxy)-

RTECS #

AG1575000

CAS #

94-74-6

Updated

July 2011

Molecular Weight

200.63

Molecular Formula

C9H9ClO3

Synonyms

((4-Chloro-o-tolyl)oxy)acetic acid
(4-Chloro-2-methylphenoxy)acetic acid
2M-4Ch
2M-4Kh
2-Methyl-4-chlorophenoxyacetic acid
2-Methyl-4-chlorphenoxyessigsaeure (German)
4-Chloro-o-cresoxyacetic acid
4-Chloro-o-toloxyacetic acid
4K-2M
Acetic acid, (4-chloro-2-methylphenoxy)-
Acme MCPA Amine 4
Agroxon
Agroxone
Anicon kombi
Anicon M
Brominal M & plus
B-Selektonon M
Chwastox 30
Chwastox Extra
Dicopur-M
Emcepan
Hedapur M 52
Hedarex M
Hedonal M
Herbicide M
Hormotuho
Kilsem
Krezone
Kwas 4-chloro-2-metylofenoksyoctowy (Polish)
Kyselina 4-chlor-2-methylfenoxyoctova (Czech)
Legumex DB
Leuna M
Leyspray
Linormone
M 40
MCP
MCPA
Mephanac
Methoxone
Netazol
Okultin M
Phenoxylene 50
Phenoxylene plus
Phenoxylene super
Razol dock killer
Rhonox
Seppic MMD
Shamrox
Soviet technical herbicide 2M-4C
Trasan
U 46 M-Fluid
Ustinex
Vacate
Vesakontuho MCPA
Weedar MCPA Concentrate
Weedone MCPA ester
Zelan

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg mildATDAEI 1,85,1990

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionoral/mouse200 mg/kgMUREAV 55,197,1978
gene conversion and mitotic recombination/Aspergillus nidulans1500 µmol/LMUREAV 204,615,1988
host-mediated assaySalmonella typhimurium/mouse200 mg/kgECBUDQ 27,182,1978
mutation in microorganisms/Saccharomyes cerevisiae30 µmol/L/3H (-enzymatic activation step)MUREAV 60,291,1979
mutation in microorganisms/Salmonella typhimurium250 µg/plate (-enzymatic activation step)MUREAV 204,615,1988
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5 mmol/LEXPEAM 30,621,1974
sister chromatid exchangeovary/hamster10 µmol/L/1HCRNGDP 5,703,1984
sister chromatid exchangeoral/hamster900 mg/kg/9D- intermittentCRNGDP 5,703,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 2 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 33,1479,1983
oral/mouse 3 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)ARZNAD 33,1479,1983
oral/mouse 1 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ARZNAD 33,1479,1983
oral/rabbit 550 mg/kg (6-27D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 26,368,2006
oral/rabbit 110 mg/kg (6-27D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 26,368,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1370 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ATDAEI 1,86,1990
intracerebral/rat lowest published toxic dose: 1605 ng/kgBehavioral: Antianxiety

Endocrine: Other changes
NEROEW 27,25,2002
intravenous/mouse lethal dose (50 percent kill): 28 mg/kgPCOC** -,711,1966
oral/guinea pig lethal dose (50 percent kill): 700 mg/kgGTPZAB 31(2),31,1987
oral/man lowest published lethal dose: 814 mg/kgBehavioral: Coma

Vascular: BP lowering not characterized in autonomic section
BMJOAE 2,629,1965
oral/mouse lethal dose (50 percent kill): 439 mg/kgRPZHAW 31,373,1980
oral/rat lethal dose (50 percent kill): 700 mg/kgGastrointestinal: Gastritis

Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration
AJVRAH 15,622,1954
skin/rabbit lethal dose (50 percent kill): >2 gm/kgATDAEI 1,86,1990
skin/rat lethal dose (50 percent kill): >1 gm/kgWRPCA2 9,119,1970
subcutaneous/mouse lowest published lethal dose: 28 mg/kgPCOC** -,711,1966
unreported route/quail lethal dose (50 percent kill): 377 mg/kgFMCHA2 -,C191,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2129 mg/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
TJEMAO 160,97,1990
oral/rat lowest published toxic dose: 4487 mg/kg/27D- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
RTOPDW 42,47,2005
oral/rat lowest published toxic dose: 4662 mg/kg/27D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
RTOPDW 42,47,2005
oral/rat lowest published toxic dose: 4037.6 mg/kg/4W- continuousLiver: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 4239.2 mg/kg/4W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in erythrocyte (RBC) count
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 3858.4 mg/kg/4W- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 4902.8 mg/kg/4W- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 4737.6 mg/kg/4W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: P
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 5224.8 mg/kg/4W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 3847.2 mg/kg/4W- continuousLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 5294.8 mg/kg/4W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 191,88,2009
oral/rat lowest published toxic dose: 14400 mg/kg/90D- continuousBehavioral: Food intake (animal)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 3,349,1975
oral/rat lowest published toxic dose: 14283 mg/kg/2Y- continuousKidney, Ureter, and Bladder: Interstitial nephritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
RTOPDW 30,223,1999

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,357,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 30,255,1983
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWJTCTDW 38,111,2000
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUTAEX 20,3,2005
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,569,2005
TOXICOLOGY REVIEWFEREAC 71,56425,2006
TOXICOLOGY REVIEWFEREAC 72,28881,2007
TOXICOLOGY REVIEWFEREAC 73,66780,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,126,1998
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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