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Acetic acid, ( (4 - chloro - o - tolyl) oxy) -

RTECS #: AG1575000

CAS #: 94-74-6


UPDATE: May 2009 MW: 200.63 MF: C9H9ClO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. ( (4 - Chloro - o - tolyl) oxy) acetic acid
  2. (4 - Chloro - 2 - methylphenoxy) acetic acid
  3. 2 - Methyl - 4 - chlorophenoxyacetic acid
  4. 2 - Methyl - 4 - chlorphenoxyessigsaeure (German)
  5. 2M - 4Ch
  6. 2M - 4Kh
  7. 4 - Chloro - o - cresoxyacetic acid
  8. 4 - Chloro - o - toloxyacetic acid
  9. 4K - 2M
  10. Acetic acid, (4 - chloro - 2 - methylphenoxy) -
  11. Acme MCPA Amine 4
  12. Agroxon
  13. Agroxone
  14. Anicon kombi
  15. Anicon M
  16. B - Selektonon M
  17. Brominal M & plus
  18. Chwastox 30
  19. Chwastox Extra
  20. Dicopur - M
  21. Emcepan
  22. Hedapur M 52
  23. Hedarex M
  24. Hedonal M
  25. Herbicide M
  26. Hormotuho
  27. Kilsem
  28. Krezone
  29. Kwas 4 - chloro - 2 - metylofenoksyoctowy (Polish)
  1. Kyselina 4 - chlor - 2 - methylfenoxyoctova (Czech)
  2. Legumex DB
  3. Leuna M
  4. Leyspray
  5. Linormone
  6. M 40
  7. MCP
  8. MCPA
  9. Mephanac
  10. Methoxone
  11. Netazol
  12. Okultin M
  13. Phenoxylene 50
  14. Phenoxylene plus
  15. Phenoxylene super
  16. Razol dock killer
  17. Rhonox
  18. Seppic MMD
  19. Shamrox
  20. Soviet technical herbicide 2M - 4C
  21. Trasan
  22. U 46 M - Fluid
  23. Ustinex
  24. Vacate
  25. Vesakontuho MCPA
  26. Weedar MCPA Concentrate
  27. Weedone MCPA ester
  28. Zelan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg mild ATDAEI 1,85,1990


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition oral
mouse
200 mg/kg MUREAV 55,197,1978
host-mediated assay mouse
Salmonella typhimurium
200 mg/kg ECBUDQ 27,182,1978
mutation in microorganisms Salmonella typhimurium 250 µg/plate (-enzymatic activation step) MUREAV 204,615,1988
mutation in microorganisms Saccharomyes cerevisiae 30 µmol/L/3 hour (-enzymatic activation step) MUREAV 60,291,1979
gene conversion and mitotic recombination Aspergillus nidulans 1,500 µmol/L MUREAV 204,615,1988
sister chromatid exchange hamster ovary 10 µmol/L/1 hour CRNGDP 5,703,1984
sister chromatid exchange oral
hamster
900 mg/kg/9 day- intermittent CRNGDP 5,703,1984
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
5 mmol/L EXPEAM 30,621,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 33,1479,1983
oral
mouse
lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 33,1479,1983
oral
mouse
lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ARZNAD 33,1479,1983
oral
rabbit
lowest published toxic dose: 550 mg/kg (6-27 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 26,368,2006
oral
rabbit
lowest published toxic dose: 110 mg/kg (6-27 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 26,368,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rat
lowest published toxic dose: 1,605 ng/kg Behavioral: Antianxiety

Endocrine: Other changes
NEROEW 27,25,2002
inhalation
rat
lethal concentration (50 percent kill): 1,370 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ATDAEI 1,86,1990
intravenous
mouse
lethal dose (50 percent kill): 28 mg/kg N/R PCOC** -,711,1966
oral
guinea pig
lethal dose (50 percent kill): 700 mg/kg N/R GTPZAB 31(2),31,1987
oral
man
lowest published lethal dose: 814 mg/kg Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section
BMJOAE 2,629,1965
oral
mouse
lethal dose (50 percent kill): 439 mg/kg N/R RPZHAW 31,373,1980
oral
rat
lethal dose (50 percent kill): 700 mg/kg Gastrointestinal: Gastritis

Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration
AJVRAH 15,622,1954
subcutaneous
mouse
lowest published lethal dose: 28 mg/kg N/R PCOC** -,711,1966
skin
rat
lethal dose (50 percent kill): >1 gm/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R ATDAEI 1,86,1990
unreported route
quail
lethal dose (50 percent kill): 377 mg/kg N/R FMCHA2 -,C191,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2,129 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
TJEMAO 160,97,1990
oral
rat
lowest published toxic dose: 14,400 mg/kg/90 day- continuous Behavioral: Food intake (animal)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 3,349,1975
oral
rat
lowest published toxic dose: 14,283 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Interstitial nephritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
RTOPDW 30,223,1999
oral
rat
lowest published toxic dose: 4,487 mg/kg/27 day- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
RTOPDW 42,47,2005
oral
rat
lowest published toxic dose: 4,662 mg/kg/27 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
RTOPDW 42,47,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,357,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 30,255,1983
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
JTCTDW 38,111,2000
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUTAEX 20,3,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,569,2005
TOXICOLOGY REVIEW
FEREAC 71,56425,2006
TOXICOLOGY REVIEW
FEREAC 72,28881,2007
TOXICOLOGY REVIEW
FEREAC 72,28881,2007
TOXICOLOGY REVIEW
FEREAC 72,28881,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,126,1998
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a postemergence herbicide for control of broadleaf weeds in agricultural applications
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ECBUDQ Ecological Bulletins. (Editorial Service of FRN, Box 6710, S-11385, Stockholm, Sweden) No.19- 1975-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a postemergence herbicide for control of broadleaf weeds in agricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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