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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, chloro-, sodium salt

RTECS #

AG1400000

CAS #

3926-62-3

Updated

July 2013

Molecular Weight

116.48

Molecular Formula

C2H2ClO2·Na

Synonyms

Chloroacetic acid sodium salt
Chloroctan sodny (Czech)
Dow defoliant
Monoxone
SMA
SMCA
Sodium monochloracetate

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 159.2 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/guinea pig lethal dose (50 percent kill): 115 mg/kgGTPZAB 31(12),53,1987
oral/chicken lethal dose (50 percent kill): 81 mg/kgPCOC** -,1047,1966
oral/domestic bird lowest published lethal dose: 100 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Gastrointestinal: Other changes
APTOA6 18,179,1961
oral/guinea pig lethal dose (50 percent kill): 99 mg/kgJIHTAB 23,78,1941
oral/mammal (species unspecified) lowest published lethal dose: 150 mg/kgBehavioral: Muscle contraction or spasticity

Gastrointestinal: Hypermotility, diarrhea

Lung, Thorax, or Respiration: Dyspnea
NVTMAF 13,271,1961
oral/mouse lethal dose (50 percent kill): 165 mg/kgJPETAB 86,336,1946
oral/rabbit lethal dose (50 percent kill): 156 mg/kgPCOC** -,1047,1966
oral/rat lethal dose (50 percent kill): 95 mg/kgJIHTAB 23,78,1941
subcutaneous/rat lowest published lethal dose: 60 mg/kgTIHEEC 18,389,2002
subcutaneous/rat lowest published lethal dose: 80 mg/kgEndocrine: Hypoglycemia

Biochemical: Metabolism (intermediary): Other
TIHEEC 18,389,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 5400 mg/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count
TXCYAC 67,171,1991

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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