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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, chloro-, ethyl ester

RTECS #

AF9110000

CAS #

105-39-5

Updated

July 2013

Molecular Weight

122.56

Molecular Formula

C4H7ClO2

Synonyms

Chloroacetic acid, ethyl ester
Ethyl alpha-chloroacetate
Ethyl chloracetate
Ethyl chloroethanoate
Ethyl monochloracetate
Ethyl monochloroacetate
Ethylester kyseliny chloroctove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg severeAJOPAA 29,1363,1946
eye /rabbit 250 µg/24H severe85JCAE -,587,1986
eye /rabbit 0.1 mL severeHPV232 -,-,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 2940 mg/kg/8W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 39,391,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 40.3 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
oral/mouse lethal dose (50 percent kill): 350 mg/kgHPV232 -,-,2001
oral/rat lethal dose (50 percent kill): 180 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair
BGTOX* 5,71,1993
oral/rat lethal dose (50 percent kill): 50 mg/kgHPV232 -,-,2001
skin/rabbit lowest published toxic dose: 100 mg/kgSkin: After topical application: Primary irritationHPV232 -,-,2001
skin/rabbit lethal dose (50 percent kill): 230 mg/kgHPV232 -,-,2001
skin/rat lethal dose (50 percent kill): 161 mg/kgEye: Lacrimation

Behavioral: Hallucinations, distorted perceptions

Skin and Appendages: Other: Hair
BGTOX* 5,71,1993
skin/rat lethal dose (50 percent kill): 161 mg/kgHPV232 -,-,2001
subcutaneous/mouse lethal dose (50 percent kill): 250 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes
JJPAAZ 3,99,1954
subcutaneous/mouse lethal dose (50 percent kill): 250 mg/kgHPV232 -,-,2001

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (5 mg/m3);KZW 1 ppm (5 mg/m3), skin, 2007
Occupational Exposure Limit-RUSSIAshort term exposure limit 7 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83397; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 919; Total Number of Female Employees Exposed 306
National Occupational Hazard Survey 1974Hazard Code 83397; Number of Industries 2; Total Number of Facilities 41; Number of Occupations 4; Total Number of Employees Exposed 290

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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