CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Acetic acid, chloro -

RTECS #: AF8575000

CAS #: 79-11-8


UPDATE: May 2009 MW: 94.50 MF: C2H3ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acide chloracetique (French)
  2. Acide monochloracetique (French)
  3. Acidomonocloroacetico (Italian)
  4. Chloracetic acid
  5. Chloroacetic acid
  6. Chloroethanoic acid
  7. Kyselina chloroctova (Czech)
  8. MCA
  1. Monochloorazijnzuur (Dutch)
  2. Monochloracetic acid
  3. Monochloressigsaeure (German)
  4. Monochloroacetic acid
  5. Monochloroethanoic acid
  6. NCI - C60231
  7. alpha - Chloroacetic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage hamster ovary 0.411 mmol/L/4 hour EMMUEG 40,134,2002
mutation in microorganisms mouse lymphocyte 548 mg/L (+enzymatic activation step) MUREAV 97,49,1982
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L ENMUDM 9,143,1987
sister chromatid exchange hamster ovary 160 mg/L EMMUEG 10(Suppl 10),1,1987
specific locus test mouse other cell types 5 mg/L/4 hour (+enzymatic activation step) EMMUEG 38,69,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159
subcutaneous
mouse
toxic dose : 1,300 mg/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 53,695,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 180 mg/m3 N/R GTPZAB 18(9),32,1974
intraperitoneal
rat
lethal dose (50 percent kill): 16,600 g/kg N/R RPTOAN 41,113,1978
intravenous
rat
lowest published toxic dose: 90 mg/kg Behavioral: Coma TXCYAC 215,48,2005
oral
man
lowest published lethal dose: 0.89 mL/kg Cardiac: Cardiomyopathy including infarction

Gastrointestinal: Ulceration or bleeding from large intestine

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTSCDR 32,197,2007
oral
rat
lethal dose (50 percent kill): 55 mg/kg N/R GTPZAB 18(9),32,1974
oral
rat
lowest published lethal dose: 225 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
TOSCF2 76,51,2003
subcutaneous
mouse
lethal dose (50 percent kill): 250 mg/kg N/R AIPTAK 116,154,1958
subcutaneous
rat
lethal dose (50 percent kill): 5 mg/kg N/R TXAPA9 22,303,1972
skin
rat
lowest published lethal dose: 125 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
TOSCF2 76,51,2003
skin
rat
lowest published toxic dose: 852 mg/kg Endocrine: Hypoglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TIHEEC 19,165,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 20,800 g/m3/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells
GTPZAB 18(9),32,1974
inhalation
rat
lowest published toxic concentration: 20,800 g/m3/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells
GTPZAB 18(9),32,1974
oral
mouse
lowest published toxic dose: 13 gm/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-396,1992
oral
mouse
lowest published toxic dose: 3,840 mg/kg/16 day- intermittent Eye: Lacrimation

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-396,1992
oral
mouse
lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent
NTIS** PB92-189372
oral
rat
lowest published toxic dose: 9,750 mg/kg/13 week- intermittent Cardiac: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-396,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
APTOA6 11,13,1955
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 636,242,2007
TOXICOLOGY REVIEW
HUTOX* -,671,1996
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 ppm (1.2 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRIA MAK 4 mg/m3 (1 ppm), JAN 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.3 ppm (1.2 mg/m3), skin, JAN2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4 mg/m3);
short term exposure limit 2 ppm (8 mg/m3), Skin, JUN2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.3 ppm (1.2 mg/m3) (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18070;
Number of Industries 9;
Total Number of Facilities 1,196;
Number of Occupations 14;
Total Number of Employees Exposed 4,726
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18070;
Number of Industries 12;
Total Number of Facilities 265;
Number of Occupations 20;
Total Number of Employees Exposed 10,912;
Total Number of Female Employees Exposed 1,723


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in synthesis of SODIUM CARBOXYMETHYL CELLULOSE and synthetic CAFFEINE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chloroacetic acid, 2008
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as intermediate in synthesis of SODIUM CARBOXYMETHYL CELLULOSE and synthetic CAFFEINE

NIOSH PROFILE (MOLYBDENUM AND ITS COMPOUNDS), SRC, 12/79

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us