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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, chloro-

RTECS #

AF8575000

CAS #

79-11-8

Updated

September 201

Molecular Weight

94.50

Molecular Formula

C2H3ClO2

Synonyms

Acide chloracetique (French)
Acide monochloracetique (French)
Acidomonocloroacetico (Italian)
alpha-Chloroacetic acid
Chloracetic acid
Chloroacetic acid
Chloroethanoic acid
Kyselina chloroctova (Czech)
MCA
Monochloorazijnzuur (Dutch)
Monochloracetic acid
Monochloressigsaeure (German)
Monochloroacetic acid
Monochloroethanoic acid
NCI-C60231

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageovary/hamster0.411 mmol/L/4HEMMUEG 40,134,2002
mutation in mammalian somatic cellslymphocyte/mouse400 mg/LENMUDM 9,143,1987
mutation in microorganismslymphocyte/mouse548 mg/L (+enzymatic activation step)MUREAV 97,49,1982
sister chromatid exchangeovary/hamster160 mg/LEMMUEG 10(Suppl 10),1,1987
specific locus testother cell types/mouse5 mg/L/4H (+enzymatic activation step)EMMUEG 38,69,2001
specific locus testovary/hamster1000 µmol/L/4HMUREAV 703,174,2010

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 100 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159
subcutaneous/mouse toxic dose: 1300 mg/kg/65W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 53,695,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 10 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/rat lethal concentration (50 percent kill): 180 mg/m3GTPZAB 18(9),32,1974
intraperitoneal/rat lethal dose (50 percent kill): 16600 µg/kgRPTOAN 41,113,1978
intravenous/rat lowest published toxic dose: 90 mg/kgBehavioral: ComaTXCYAC 215,48,2005
oral/man lowest published lethal dose: 0.89 mL/kgCardiac: Cardiomyopathy including infarction

Gastrointestinal: Ulceration or bleeding from large intestine

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTSCDR 32,197,2007
oral/rat lowest published lethal dose: 225 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
TOSCF2 76,51,2003
oral/rat lethal dose (50 percent kill): 55 mg/kgGTPZAB 18(9),32,1974
skin/rat lowest published lethal dose: 125 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
TOSCF2 76,51,2003
skin/rat lowest published toxic dose: 852 mg/kgEndocrine: Hypoglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TIHEEC 19,165,2003
subcutaneous/mouse lethal dose (50 percent kill): 250 mg/kgAIPTAK 116,154,1958
subcutaneous/rat lethal dose (50 percent kill): 5 mg/kgTXAPA9 22,303,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 20800 µg/m3/17W- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells
GTPZAB 18(9),32,1974
inhalation/rat lowest published toxic concentration: 20800 µg/m3/17W- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells
GTPZAB 18(9),32,1974
oral/mouse lowest published toxic dose: 13 gm/kg/13W- intermittentLiver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-396,1992
oral/mouse lowest published toxic dose: 3840 mg/kg/16D- intermittentEye: Lacrimation

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-396,1992
oral/mouse lowest published toxic dose: 25750 mg/kg/103W- intermittentBlood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent
NTIS** PB92-189372
oral/rat lowest published toxic dose: 9750 mg/kg/13W- intermittentCardiac: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-396,1992

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWAPTOA6 11,13,1955
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 636,242,2007
TOXICOLOGY REVIEWHUTOX* -,671,1996
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWMUREAV 727,42,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.3 ppm (1.2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (4 mg/m3);KZW 1 ppm (4 mg/m3), skin, 2007
Occupational Exposure Limit-FINLANDceiling concentration 1 ppm (3.9 mg/m3), skin, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.3 ppm (1.2 mg/m3), skin, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (4 mg/m3);short term exposure limit 2 ppm (8 mg/m3), Skin, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.3 ppm (1.2 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 18070; Number of Industries 12; Total Number of Facilities 265; Number of Occupations 20; Total Number of Employees Exposed 10912; Total Number of Female Employees Exposed 1723
National Occupational Hazard Survey 1974Hazard Code 18070; Number of Industries 9; Total Number of Facilities 1196; Number of Occupations 14; Total Number of Employees Exposed 4726

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Chloroacetic acid, 2008
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