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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, benzyl ester

RTECS #

AF5075000

CAS #

140-11-4

Updated

September 201

Molecular Weight

150.19

Molecular Formula

C9H10O2

Synonyms

Acetic acid, phenylmethyl ester
alpha-Acetoxytoluene
Benzyl acetate
Benzyl acetate (ACGIH)
Benzyl ethanoate
Benzylester kyseliny octove (Czech)
NCI-C06508
Phenylmethyl acetate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 100 mg/24H moderateCTOIDG 94(8),41,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster600 mg/LMUREAV 369,243,1996
DNA Damagelymphocyte/human50 mmol/LFCTOD7 48,1239,2010
DNA repair/Bacillus subtilis21 mg/discOIGZDE 34,267,1985
mutation in mammalian somatic cellslymphocyte/mouse700 mg/LSCIEAS 236,933,1987
mutation in microorganismslymphocyte/human1500 mg/L (+enzymatic activation step)MUREAV 196,61,1988
mutation in microorganismslymphocyte/mouse500 mg/L (+enzymatic activation step)MUREAV 196,61,1988
other mutation test systemsoral/mouse1600 mg/kgMUREAV 343,157,1995
other mutation test systemsoral/Drosophila melanogaster10 mmol/LFCTOD7 46,1034,2008
phage inhibition capacity/Escherichia coli6250 ng/wellMUREAV 260,349,1991

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 258 gm/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-250,1986
oral/mouse lowest published toxic dose: 515000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Gastrointestinal: Tumors
NTIS** PB87-115044
oral/mouse lowest published toxic dose: 515000 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV141 -,-,2001
oral/rat lowest published toxic dose: 258 gm/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-250,1986
oral/rat lowest published toxic dose: 72000 mg/kg/180D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Facilitates action of known carcinogens
HPV141 -,-,2001
oral/rat lowest published toxic dose: 257500 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Other reproductive system tumors
NTIS** PB87-115044

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lethal concentration (50 percent kill): 245 ppm/8HAMIHAB 21,28,1960
inhalation/human lowest published toxic concentration: 50 ppmBehavioral: Antipsychotic

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes
TGNCDL 2,31,1961
inhalation/human lowest published toxic concentration: 0.015 mg/m3Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Cough
GISAAA -,7,1993
inhalation/mouse Lowest published lethal concentration: 1300 mg/m3/22HBehavioral: General anestheticAGGHAR 5,1,1933
oral/guinea pig lethal dose (50 percent kill): 2200 mg/kgGISAAA 50(7),17,1985
oral/mouse lethal dose (50 percent kill): 830 mg/kgGISAAA 50(7),17,1985
oral/mouse lowest published lethal dose: 2000 mg/kgHPV141 -,-,2001
oral/rabbit lethal dose (50 percent kill): 2640 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV141 -,-,2001
oral/rabbit lethal dose (50 percent kill): 2200 mg/kgGISAAA 50(7),17,1985
oral/rat lowest published lethal dose: 4000 mg/kgHPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 2490 mg/kgBehavioral: Somnolence (general depressed activity)HPV141 -,-,2001
skin/cat lowest published lethal dose: 10 gm/kgBehavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 84,358,1945
skin/rabbit lethal dose (50 percent kill): >5 gm/kgFCTXAV 11,875,1973
subcutaneous/guinea pig lowest published lethal dose: 3 gm/kgAGGHAR 5,1,1933
subcutaneous/rabbit lowest published lethal dose: 4 gm/kgBehavioral: Convulsions or effect on seizure thresholdAGGHAR 5,1,1933

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) lowest published toxic dose: 4200 mg/kg/21D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
GISAAA 50(7),17,1985
oral/mouse lowest published toxic dose: 271 gm/kg/13W- continuousBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-431,1993
oral/mouse lowest published toxic dose: 28 gm/kg/14D- intermittentGastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-250,1986
oral/mouse lowest published toxic dose: 718900 mg/kg/13W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/mouse lowest published toxic dose: 6000 mg/kg/3D- intermittentBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 355 gm/kg/13W- continuousBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-431,1993
oral/rat lowest published toxic dose: 65 gm/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-250,1986
oral/rat lowest published toxic dose: 42.5 gm/kg/17W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainEVHPAZ 68,197,1986
oral/rat lowest published toxic dose: 321.3 gm/kg/17W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainEVHPAZ 68,197,1986
oral/rat lowest published toxic dose: 56 gm/kg/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV141 -,-,2001
oral/rat lowest published toxic dose: 98 gm/kg/28D- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 28000 mg/kg/14D- intermittentGastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 65000 mg/kg/13W- intermittentBehavioral: Ataxia

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 40,109,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1255,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 40,109,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1255,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1255,1999
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (62 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (61 mg/m3), MAY2011
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (61 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 01600; Number of Industries 107; Total Number of Facilities 17141; Number of Occupations 108; Total Number of Employees Exposed 275806; Total Number of Female Employees Exposed 133629
National Occupational Hazard Survey 1974Hazard Code 01600; Number of Industries 11; Total Number of Facilities 512; Number of Occupations 42; Total Number of Employees Exposed 93580

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
NTP Carcinogenesis Studies (gavage);some evidence:mouse,rat NTPTR* NTP-TR-250,1986
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