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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetanilide, 2-chloro-2',6'-diethyl-N-(methoxymethyl)-

RTECS #

AE1225000

CAS #

15972-60-8

Updated

December 2013

Molecular Weight

269.80

Molecular Formula

C14H20ClNO2

Synonyms

2-Chloro-2',6'-diethyl-N-(methoxymethyl)acetanilide
2-Chloro-N-(2,6-diethyl)phenyl-N-methoxymethylacetamide
Acetamide, 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)- (9CI)
Alachlor
Alachlore
Alanex
Alanox
Alatox 480
Alochlor
Chloressigsaeure-N-(methoxymethyl)-2,6-diaethylanilid (German)
CP 50144
Lasagrin
Lasso
Lasso micro-tech
LAZO
Metachlor
Methachlor
Pillarzo

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 mg/LEMMUEG 19,77,1992
Cytogenetic Analysisintraperitoneal/rat1250 µg/kgMUREAV 116,341,1983
Cytogenetic Analysisoral/mouse72 mg/kg/30D-continuousEMMUEG 19,77,1992
Cytogenetic Analysisovary/hamster10 mg/LMUREAV 188,241,1987
Cytogenetic Analysisoral/rat11.34 gm/kg/90D-continuousTOXID9 72(Supp 1),228,2003
DNA Damagelymphocyte/human5 mg/LMUREAV 344,41,1995
gene conversion and mitotic recombination/Saccharomyes cerevisiae33 µg/plateMUREAV 136,233,1984
micronucleus testlymphocyte/human40 mg/LMUREAV 441,95,1999
mutation in mammalian somatic cellslymphocyte/mouse5620 µg/LTOSCF2 49,202,1999
mutation in microorganisms/Salmonella typhimurium8 µg/plate (+enzymatic activation step)KHZDAN 29(1),26,1986
mutation in microorganisms/Other microorganisms90 mg/L (-enzymatic activation step)JASIAB 104,571,1985
other mutation test systemsoral/mouse216 mg/kg/90D-continuousEMMUEG 19,77,1992
sister chromatid exchangelymphocyte/human10 µmol/LMUREAV 395,159,1997
sister chromatid exchangelymphocyte/human5 mg/LMUREAV 441,95,1999
sister chromatid exchangeovary/hamster10 µmol/LMUREAV 395,159,1997
specific locus testoral/Drosophila melanogaster1 mmol/LMUREAV 280,291,1992

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 142 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TIHEEC 3,383,1987
oral/rat lowest published toxic dose: 45990 mg/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
TOPADD 33,593,2005
oral/rat lowest published toxic dose: 102 gm/kg/2.2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors
NNGADV 24,75,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lethal concentration (50 percent kill): >5100 mg/m3TIHEEC 3,383,1987
inhalation/rat lethal concentration (50 percent kill): >23.4 gm/m3/6HENTOX* -,58,2005
intraperitoneal/rat lowest published toxic dose: 499 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 1,54,2001
intraperitoneal/rat lowest published lethal dose: 600 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 48,392,1999
oral/mammal (species unspecified) lethal dose (50 percent kill): 3 gm/kgGUCHAZ 6,3,1973
oral/mouse lethal dose (50 percent kill): 462 mg/kgGTPZAB 21(12),30,1977
oral/rabbit lethal dose (50 percent kill): 1740 mg/kgNNGADV 24,75,1999
oral/rat lethal dose (50 percent kill): 930 mg/kgTIHEEC 3,383,1987
oral/rat lowest published toxic dose: 63 mg/kgOlfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Other
TOXID9 60,42,2001
skin/rabbit lethal dose (50 percent kill): 3500 mg/kgGUCHAZ 6,3,1973
skin/rat lethal dose (50 percent kill): 1200 mg/kgYKYUA6 38,89,1987
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1200 mg/kg30ZDA9 -,126,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 300 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 193,66,2003
oral/Dog lowest published toxic dose: 4725 mg/kg/27W- intermittentLiver: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NNGADV 24,75,1999
oral/Dog lowest published toxic dose: 1092 mg/kg/1Y- intermittentGastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia
NNGADV 24,75,1999
oral/Dog lowest published toxic dose: 910 mg/kg/26W- intermittentLiver: Changes in liver weightRCTOE4 104,9,1988
oral/mouse lowest published toxic dose: 2100 mg/kg/21D- intermittentLiver: Liver function tests impaired

Liver: Changes in liver weight
AECTCV 24,449,1993
oral/mouse lowest published toxic dose: 16380 mg/kg/13W- continuousLiver: Changes in liver weightNNGADV 24,75,1999
oral/mouse lowest published toxic dose: 43134 mg/kg/79W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NNGADV 24,75,1999
oral/rat lowest published toxic dose: 15120 mg/kg/17W- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FAATDF 33,16,1996
oral/rat lowest published toxic dose: 10192 mg/kg/2Y- intermittentEye: Corneal damage

Liver: Other changes
RCTOE4 104,9,1988
oral/rat lowest published toxic dose: 15120 mg/kg/120D- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FAATDF 33,16,1996
oral/rat lowest published toxic dose: 11550 mg/kg/110W- continuousOlfaction: TumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 1260 mg/kg/10D- continuousOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TOPADD 33,593,2005
oral/rat lowest published toxic dose: 1260 mg/kg/10D- continuousOlfaction: Other olfaction effects

Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,272,2008
oral/rat lowest published toxic dose: 11466 mg/kg/91D- continuousOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other
TOXID9 -,272,2008
oral/rat lowest published toxic dose: 1260 mg/kg/10D- continuousOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases
FCTOD7 47,1051,2009
oral/rat lowest published toxic dose: 7560 mg/kg/60D- continuousOlfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 47,1051,2009
unreported route/rat lowest published toxic dose: 539.6 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 66,321,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,58,2005
TOXICOLOGY REVIEWMUREAV 627,106,2007
TOXICOLOGY REVIEWMUTAEX 20,245,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 71,43906,2006
TOXICOLOGY REVIEWFEREAC 72,39318,2007
TOXICOLOGY REVIEWFEREAC 72,54579,2007
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 23,207,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,82,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
On EPA IRIS database
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