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Acetamide, thio -

RTECS #: AC8925000

CAS #: 62-55-5


UPDATE: May 2009 MW: 75.14 MF: C2H5NS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acetothioamide
  2. Ethanethioamide
  3. RCRA waste number U218
  4. Thiacetamide
  1. Thioacetamide
  2. Thioacetimidic acid
  3. USAF CB - 21
  4. USAF EK - 1719


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis monkey kidney 50 mg/L ECREAL 57,193,1969
cytogenetic analysis intraperitoneal
rat
150 mg/kg JNCIAM 46,49,1971
cytogenetic analysis parenteral
rat
150 mg/kg ECREAL 55,435,1969
DNA adduct Escherichia coli 50 mol/L MUREAV 89,95,1981
DNA adduct intraperitoneal
rat
60 mg/kg CNREA8 36,4647,1976
DNA damage rat liver 300 mmol/L SinJF# 26OCT1982
DNA inhibition human HeLa cell 150 mmol/L CRNGDP 13,2389,1992
DNA inhibition mouse fibroblast 1 mmol/L JOUOD4 5,147,1983
DNA repair Escherichia coli 400 g/well MUREAV 46,53,1977
unscheduled DNA synthesis intraperitoneal
mouse
50 g/kg CHBIE4 3,1,1986
unscheduled DNA synthesis oral
rat
2,940 mg/kg/12 week- intermittent CNREA8 29,2039,1969
unscheduled DNA synthesis subcutaneous
rat
100 mg/kg PLMEAA 57,25,1991
host-mediated assay mouse
Salmonella typhimurium
125 mg/kg JJIND8 62,911,1979
host-mediated assay mouse
Escherichia coli
300 mg/kg MUREAV 272,161,1992
mutation in microorganisms mouse lymphocyte 3,200 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),37,1988
mutation in microorganisms Saccharomyes cerevisiae 19,900 mol/L (-enzymatic activation step) MGGEAE 174,39,1979
micronucleus test monkey kidney 100 mg/L ECREAL 57,193,1969
micronucleus test oral
mouse
670 mol/kg MUREAV 192,141,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 2 pph JJIND8 62,901,1979
mutation in mammalian somatic cells mouse lymphocyte 623 mg/L EMMUEG 12(Suppl 13),37,1988
morphological transform hamster embryo 100 g/L IJCNAW 19,642,1977
morphological transform mouse embryo 500 g/L JNCIAM 52,1167,1974
morphological transform mouse fibroblast 1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform oral
rat
1,512 mg/kg/6 week CRNGDP 9,387,1988
morphological transform rat embryo 30 mg/L JJIND8 67,1303,1981
other mutation test systems human fibroblast 100 mg/L BJCAAI 42,112,1980
other mutation test systems monkey kidney 25 mg/L/48 hour ECREAL 57,193,1969
other mutation test systems other microorganisms 10 mg/L CYTZAM 11,392,1975
other mutation test systems intraperitoneal
rat
5 mg/kg RCOCB8 23,639,1979
other mutation test systems subcutaneous
rat
100 mg/kg PLMEAA 57,25,1991
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
100 ppm/24 hour MUREAV 58,259,1978
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
2,500 ppm MUREAV 58,259,1978
specific locus test oral
mouse
10,240 mol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1 gm/kg (7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 85DJA5 -,95,1971
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
FHCYAI 8,11,1970
subcutaneous
mouse
lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 10 gm/kg/39 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
BJCAAI 24,498,1970
oral
mouse
toxic dose : 7,956 mg/kg/32 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
JNCIAM 56,493,1976
oral
mouse
toxic dose : 18,360 mg/kg/73 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
IJCAAR 9,154,1972
oral
rat
lowest published toxic dose: 7,350 mg/kg/40 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JJIND8 79,1047,1987
oral
rat
toxic dose : 6,000 mg/kg/43 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
ONCOBS 38,249,1981
oral
rat
toxic dose : 7,200 mg/kg/51 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ONCOBS 38,249,1981
oral
rat
toxic dose : 1,008 mg/kg/9 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NATUAS 175,257,1955
oral
rat
toxic dose : 9,900 mg/kg/71 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
ONCOBS 38,249,1981
oral
rat
toxic dose : 1,600 mg/kg/12 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CNREA8 28,1703,1968
oral
rat
toxic dose : 5,140 mg/kg/47 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Prostate tumors
JPBAA7 72,415,1956
oral
rat
toxic dose : 7,665 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
JJIND8 71,553,1983
oral
rat
toxic dose : 4,320 mg/kg/34 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ECEBDI 45,34,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Liver: Liver function tests impaired TOXID9 72,322,2003
intraperitoneal
mouse
lowest published lethal dose: 1,000 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 188,122,2003
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Immunological Including Allergic: Decrease in cellular immune response TOLED5 136,163,2003
intraperitoneal
mouse
lowest published toxic dose: 150 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOXID9 44,329,2005
intraperitoneal
mouse
lowest published toxic dose: 150 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOXID9 44,329,2005
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal TOXID9 44,329,2005
intraperitoneal
mouse
lowest published toxic dose: 150 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 44,329,2005
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 200,219,2004
intraperitoneal
mouse
lethal dose (50 percent kill): 300 mg/kg N/R ENTOX* -,172,2005
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 224,81,2007
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 228,295,2008
intraperitoneal
rat
lowest published lethal dose: 600 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOSCF2 45,233,1998
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Liver: Liver function tests impaired TOXID9 72,199,2003
intraperitoneal
rat
lowest published lethal dose: 50 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 72,272,2003
intraperitoneal
rat
lowest published toxic dose: 496 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCPCA6 66,917,2003
intraperitoneal
rat
lethal dose : 600 mg/kg N/R ETOPFR 18,149,2004
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 199,97,2004
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Liver: Other changes TOXID9 44,149,2005
intraperitoneal
rat
lowest published lethal dose: 300 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,390,2005
intraperitoneal
rat
lowest published lethal dose: 300 mg/kg Liver: Jaundice (or hyperbilirubinemia) hepatocellular

Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,390,2005
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ARTODN 78,86,2004
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases MUREAV 603,64,2006
intraperitoneal
rat
lowest published lethal dose: 600 mg/kg Liver: Liver function tests impaired

Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,365,2002
intraperitoneal
rat
lowest published lethal dose: 600 mg/kg N/R TOXID9 60,349,2001
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 207,89,2005
intraperitoneal
rat
lowest published lethal dose: 300 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 207,89,2005
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 211,221,2006
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 207,89,2005
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 81,201,2007
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes
JTPAE7 17,231,2004
intravenous
rat
lowest published toxic dose: 150 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
oral
rat
lowest published toxic dose: 200 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Endocrine: Change in GH

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 26,25,2001
oral
rat
lowest published toxic dose: 150 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Metabolism (intermediary): Lipids including transport
CRTOEC 18,639,2005
oral
rat
lethal dose (50 percent kill): 301 mg/kg N/R ENTOX* -,172,2005
oral
rat
lowest published toxic dose: 45 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,469,2007
oral
rat
lowest published toxic dose: 45 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes
TXCYAC 250,15,2008
subcutaneous
mouse
lowest published lethal dose: 2 gm/kg N/R AIPTAK 12,447,1904
subcutaneous
rat
lethal dose : >200 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JOGAET 29,293,1994
subcutaneous
rat
lowest published toxic dose: 100 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JOETD7 49,119,1995
unreported route
mouse
lowest published toxic dose: 300 mg/kg Biochemical: Metabolism (intermediary): Other proteins TOXID9 72,81,2003
unreported route
rat
lowest published toxic dose: 30 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes TOXID9 72,107,2003
unreported route
rat
lowest published toxic dose: 200 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 44,104,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 350 mg/kg/7 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
TOLED5 114,225,2000
intraperitoneal
mouse
lowest published toxic dose: 600 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Other changes TXAPA9 224,81,2007
intraperitoneal
mouse
lowest published toxic dose: 1,200 mg/kg/3 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) TXAPA9 224,81,2007
intraperitoneal
rat
lowest published toxic dose: 1,050 mg/kg/3 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXAPA9 159,161,1999
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg/1 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOPADD 15,19,2002
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/3 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOPADD 15,19,2002
intraperitoneal
rat
lowest published toxic dose: 1,400 mg/kg/7 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOPADD 15,19,2002
intraperitoneal
rat
lowest published toxic dose: 2,400 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 21,253,2006
intraperitoneal
rat
lowest published toxic dose: 2,000 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 45,2228,2007
intraperitoneal
rat
lowest published toxic dose: 4,800 mg/kg/12 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)
TXCYAC 246,148,2008
intraperitoneal
rat
lowest published toxic dose: 3,000 mg/kg/5 week- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight
JTPAE7 17,177,2004
intraperitoneal
rat
lowest published toxic dose: 1,200 mg/kg/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 17,219,2004
intraperitoneal
rat
lowest published toxic dose: 2,400 mg/kg/4 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTPAE7 17,219,2004
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg/1 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes
JTPAE7 17,231,2004
oral
rat
lowest published toxic dose: 2,520 L/kg/12 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
JTSCDR 24,369,1999
oral
rat
lowest published toxic dose: 933 mg/kg/10 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VAAZA2 32,57,1979
oral
rat
lowest published toxic dose: 240 mg/kg/4 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 16,626,1970
oral
rat
lowest published toxic dose: 1,890 mg/kg/4 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 48,81,1988
oral
rat
lowest published toxic dose: 3,648 mg/kg/27 week- continuous Liver: Other changes JIHTAB 31(3),158,1949
oral
rat
lowest published toxic dose: 4,500 mg/kg/90 day- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
CYLPDN 21,777,2000
oral
rat
lowest published toxic dose: 26.6 mg/kg/14 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 72,8,2003
oral
rat
lowest published toxic dose: 4,032 mg/kg/28 day- continuous Liver: Other changes TOXID9 72,235,2003
oral
rat
lowest published toxic dose: 2,520 mg/kg/12 week- continuous Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) TXAPA9 197,302,2004
oral
rat
lowest published toxic dose: 900 mg/kg/30 day- continuous Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 1,91,2005
oral
rat
lowest published toxic dose: 900 mg/kg/30 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 1,91,2005
oral
rat
lowest published toxic dose: 1,680 mg/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain CRNGDP 25,631,2004
oral
rat
lowest published toxic dose: 1,890 mg/kg/9 week- continuous Liver: Other changes CRNGDP 25,631,2004
oral
rat
lowest published toxic dose: 3,360 mg/kg/16 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Tumors
CRNGDP 25,631,2004
oral
rat
lowest published toxic dose: 4,200 mg/kg/20 week- continuous Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) CRNGDP 25,631,2004
oral
rat
lowest published toxic dose: 420 mg/kg/28 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes
TXCYAC 250,15,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 7,77,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 7,77,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CRTXB2 1(1),93,1971
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,172,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83086;
Number of Industries 2;
Total Number of Facilities 47;
Number of Occupations 2;
Total Number of Employees Exposed 1,130
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83086;
Number of Industries 3;
Total Number of Facilities 53;
Number of Occupations 6;
Total Number of Employees Exposed 786;
Total Number of Female Employees Exposed 592


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Weakly Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a substitute for HYDROGEN SULPHIDE in the chemical laboratory
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CHBIE4 Chronobiology International. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1984 -
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
CYTZAM Cytobiologie. (Stuttgart, Fed. Rep. Ger.) V.1-18, 1969-79. For publisher information, see EJCBDN.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.44- 1976-
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
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Used as a substitute for HYDROGEN SULPHIDE in the chemical laboratory

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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