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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetamide, 2-fluoro-

RTECS #

AC1225000

CAS #

640-19-7

Updated

July 2011

Molecular Weight

77.07

Molecular Formula

C2H4FNO

Synonyms

2-Fluoroacetamide
AFL 1081
Amid kyseliny fluoroctove (Czech)
Compound 1081
Fluorakil 100
Fluoroacetamide
Fluoroacetic acid amide
Flutritex 1
Fussol
Megatox
Monofluoroacetamide
Navron
RCRA waste number P057
Rodex

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat4 mg/kgVAAZA2 1,346,1968
Cytogenetic Analysislung/mammal (species unspecified)300 µmol/LHKXUDL 3,94,1983
sperm morphologyintraperitoneal/rat4 mg/kgVAAZA2 1,346,1968

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 90 mg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductEXPEAM 20,492,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 141 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mouse lethal concentration (50 percent kill): 550 mg/m3ABCHA6 31,1294,1967
intraperitoneal/mouse lethal dose (50 percent kill): 85 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
BCPCA6 12,1201,1963
intraperitoneal/rat lethal dose (50 percent kill): 12 mg/kgJSFAAE 8,400,1957
intravenous/monkey lethal dose (50 percent kill): 5 mg/kgSKEZAP 9,1,1968
intravenous/rabbit lethal dose (50 percent kill): 250 µg/kgJCSOA9 -,912,1949
oral/chicken lethal dose (50 percent kill): 4250 µg/kgFLUOA4 10,34,1976
oral/human lowest published lethal dose: 2 mg/kgSKEZAP 9,1,1968
oral/mouse lethal dose (50 percent kill): 25 mg/kgABCHA6 31,1294,1967
oral/quail lethal dose (50 percent kill): 13 mg/kgJRPFA4 48,371,1976
oral/rat lowest published lethal dose: 11 mg/kgCardiac: EKG changes not diagnostic of above

Cardiac: Change in rate

Lung, Thorax, or Respiration: Other changes
JAPTO* 27,538,2007
oral/rat lethal dose (50 percent kill): 5750 µg/kgPCOC** -,538,1966
oral/wild bird lethal dose (50 percent kill): 5620 µg/kgAECTCV 12,355,1983
skin/mouse lethal dose (50 percent kill): 34 mg/kgSKEZAP 9,1,1968
skin/rat lethal dose (50 percent kill): 80 mg/kgWRPCA2 9,119,1970
subcutaneous/mouse lethal dose (50 percent kill): 34 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Skin and Appendages: Other: Hair
NHOZAX 26,203,1972
subcutaneous/rat lowest published lethal dose: 50 mg/kgCardiac: Change in rate

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,538,2007
subcutaneous/rat lowest published toxic dose: 3 mg/kgCardiac: Change in rateJAPTO* 27,538,2007
unreported route/human lowest published lethal dose: 5 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Gastrointestinal: Nausea or vomiting
34ZIAG -,274,1969
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 4 mg/kg30ZDA9 -,119,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/cat lowest published toxic dose: 700 µg/kg/7D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJWIDAW 15,319,1979
oral/wild bird lowest published toxic dose: 15 mg/kg/7D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJWIDAW 15,319,1979

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCHREAY 48,225,1951
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWTPHSDY 29,361,2008
TOXICOLOGY REVIEWJFSCAS (5),76,1965

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,255,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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