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Acetamide, 2 - fluoro -

RTECS #: AC1225000

CAS #: 640-19-7


UPDATE: May 2009 MW: 77.07 MF: C2H4FNO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Fluoroacetamide
  2. AFL 1081
  3. Amid kyseliny fluoroctove (Czech)
  4. Compound 1081
  5. Fluorakil 100
  6. Fluoroacetamide
  7. Fluoroacetic acid amide
  1. Flutritex 1
  2. Fussol
  3. Megatox
  4. Monofluoroacetamide
  5. Navron
  6. RCRA waste number P057
  7. Rodex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis mammal (species unspecified) lung 300 mol/L HKXUDL 3,94,1983
cytogenetic analysis intraperitoneal
rat
4 mg/kg VAAZA2 1,346,1968
sperm morphology intraperitoneal
rat
4 mg/kg VAAZA2 1,346,1968


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 90 mg/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EXPEAM 20,492,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 550 mg/m3 N/R ABCHA6 31,1294,1967
intraperitoneal
mouse
lethal dose (50 percent kill): 85 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
BCPCA6 12,1201,1963
intraperitoneal
rat
lethal dose (50 percent kill): 12 mg/kg N/R JSFAAE 8,400,1957
intravenous
monkey
lethal dose (50 percent kill): 5 mg/kg N/R SKEZAP 9,1,1968
intravenous
rabbit
lethal dose (50 percent kill): 250 g/kg N/R JCSOA9 -,912,1949
oral
wild bird
lethal dose (50 percent kill): 5,620 g/kg N/R AECTCV 12,355,1983
oral
chicken
lethal dose (50 percent kill): 4,250 g/kg N/R FLUOA4 10,34,1976
oral
human
lowest published lethal dose: 2 mg/kg N/R SKEZAP 9,1,1968
oral
mouse
lethal dose (50 percent kill): 25 mg/kg N/R ABCHA6 31,1294,1967
oral
quail
lethal dose (50 percent kill): 13 mg/kg N/R JRPFA4 48,371,1976
oral
rat
lethal dose (50 percent kill): 5,750 g/kg N/R PCOC** -,538,1966
subcutaneous
mouse
lethal dose (50 percent kill): 34 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Skin and Appendages: Other: Hair
NHOZAX 26,203,1972
skin
mouse
lethal dose (50 percent kill): 34 mg/kg N/R SKEZAP 9,1,1968
skin
rat
lethal dose (50 percent kill): 80 mg/kg N/R WRPCA2 9,119,1970
unreported route
human
lowest published lethal dose: 5 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Gastrointestinal: Nausea or vomiting
34ZIAG -,274,1969
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 4 mg/kg N/R 30ZDA9 -,119,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
wild bird
lowest published toxic dose: 15 mg/kg/7 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JWIDAW 15,319,1979
oral
cat
lowest published toxic dose: 700 g/kg/7 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JWIDAW 15,319,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CHREAY 48,225,1951
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,255,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a rodenticide and as an insecticide on fruit
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692, Warren, MI 48090) V.3- 1970-
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981-
HUTOX*
JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4.
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JSFAAE Journal of the Science of Food and Agriculture. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1950-
JWIDAW Journal of Wildlife Diseases. (Wildlife Disease Assoc., POB 886, Ames, IA 50010) V.6- 1970-
NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1968-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a rodenticide and as an insecticide on fruit

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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