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Acenaphthene

RTECS #: AB1000000

CAS #: 83-32-9


UPDATE: May 2009 MW: 154.22 MF: C12H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Dihydroacenaphthylene
  2. 1,8 - Ethylenenaphthalene
  3. Acenaphthylene, 1,2 - dihydro -
  1. Naphthyleneethylene
  2. peri - Ethylenenaphthalene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002
mutation in microorganisms other microorganisms 3 mg (-enzymatic activation step) MIKBA5 54,360,1985
mutation in microorganisms Salmonella typhimurium 0.5 nmol/plate/48 hour (-enzymatic activation step) MUREAV 557,99,2004
mutation in microorganisms Salmonella typhimurium 55,556 pmol/L (+enzymatic activation step) MUREAV 626,88,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 600 mg/kg N/R VCVGH* -,230,1990
intratracheal
rat
lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Other changes VCVGH* -,230,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 12 mg/m3/4 hour/22 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) GTPZAB 14(6),46,1970
unreported route
mouse
lowest published toxic dose: 180 mg/kg/12 day- intermittent Immunological Including Allergic: Uncharacterized (multiple organ involvement) TOXID9 48,13,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 540,89,2003
TOXICOLOGY REVIEW
MUREAV 558,155,2004
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
TOLED5 140-141,353,2003
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,11,2005
TOXICOLOGY REVIEW
MUREAV 681,93,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4337;
Number of Industries 12;
Total Number of Facilities 485;
Number of Occupations 14;
Total Number of Employees Exposed 1,920
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4337;
Number of Industries 3;
Total Number of Facilities 164;
Number of Occupations 3;
Total Number of Employees Exposed 1,064


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye intermediate, insecticide, fungicide and for manufacture of plastics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515


REFERENCES:

CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MIKBA5 Mikrobiologiya. Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a dye intermediate, insecticide, fungicide and for manufacture of plastics

RTECS Compound Description:
   Mutagen

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