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Acetamide, 2 - chloro -

RTECS #: AB5075000

CAS #: 79-07-2


UPDATE: May 2008 MW: 93.52 MF: C2H4ClNO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Chloroacetamide
  2. 2 - Chloroethanamide
  3. Chloracetamid (German)
  4. Chloracetamide
  5. Chloroacetamide
  1. Mergal AF
  2. Microcide
  3. USAF DO - 29
  4. alpha - Chloroacetamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
guinea pig
500 ppm N/R TXCYAC 211,165,2005


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 2 mmol/L (-enzymatic activation step) MUREAV 210,255,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intravenous
mouse
lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#03764
oral
dog
lethal dose (50 percent kill): 31 mg/kg N/R CHHTAT 58,462,1978
oral
mouse
lethal dose (50 percent kill): 155 mg/kg N/R CHHTAT 58,462,1978
oral
rat
lethal dose (50 percent kill): 138 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0536947
oral
rabbit
lethal dose (50 percent kill): 122 mg/kg N/R CHHTAT 58,462,1978
unreported route
rat
lethal dose (50 percent kill): 70 mg/kg N/R ARZNAD 19,1073,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,138 mg/kg/13 week- intermittent Endocrine: Thyroid weight (goiter)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0536952
oral
rabbit
lowest published toxic dose: 960 mg/kg/30 day- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Cardiac: EKG changes not diagnostic of above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CHHTAT 58,462,1978
skin
rabbit
lowest published toxic dose: 6 gm/kg/30 day- intermittent Blood: Changes in spleen

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536947


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 636,242,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1156;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 90


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72.
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Mutagen

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