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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetamide, 2-chloro-

RTECS #

AB5075000

CAS #

79-07-2

Updated

May 2008

Molecular Weight

93.52

Molecular Formula

C2H4ClNO

Synonyms

2-Chloroacetamide
2-Chloroethanamide
alpha-Chloroacetamide
Chloracetamid (German)
Chloracetamide
Chloroacetamide
Mergal AF
Microcide
USAF DO-29

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /guinea pig 500 ppmTXCYAC 211,165,2005

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli2 mmol/L (-enzymatic activation step)MUREAV 210,255,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgCSLNX* NX#03764
oral/Dog lethal dose (50 percent kill): 31 mg/kgCHHTAT 58,462,1978
oral/mouse lethal dose (50 percent kill): 155 mg/kgCHHTAT 58,462,1978
oral/rabbit lethal dose (50 percent kill): 122 mg/kgCHHTAT 58,462,1978
oral/rat lethal dose (50 percent kill): 138 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0536947
unreported route/rat lethal dose (50 percent kill): 70 mg/kgARZNAD 19,1073,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 960 mg/kg/30D- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Cardiac: EKG changes not diagnostic of above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CHHTAT 58,462,1978
oral/rat lowest published toxic dose: 1138 mg/kg/13W- intermittentEndocrine: Thyroid weight (goiter)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0536952
skin/rabbit lowest published toxic dose: 6 gm/kg/30D- intermittentBlood: Changes in spleen

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536947

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 636,242,2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T1156; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 90

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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