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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetamide

RTECS #

AB4025000

CAS #

60-35-5

Updated

December 2012

Molecular Weight

59.08

Molecular Formula

C2H5NO

Synonyms

Acetic acid amide
Acetimidic acid
Amid kyseliny octove (Czech)
Ethanamide
Methanecarboxamide
NCI-C02108

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagemammary gland/human5.8 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
micronucleus testoral/mouse100 mg/kg/30H- intermittentCRTXB2 31,139,2001
micronucleus testoral/mouse3390 µmol/kgMUREAV 192,141,1987
morphological transformembryo/hamster1 mg/LIJCNAW 19,642,1977
morphological transformfibroblast/mouse0.01 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
morphological transformembryo/rat5 mg/LJNCIAM 51,799,1973
other mutation test systemsAscites tumor/mouse10 pphIDZAAW 51,53,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 39 gm/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 30,1557,1980
oral/rabbit 13 gm/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ARZNAD 30,1557,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 517 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Blood: Lymphoma including Hodgkin's disease
JEPTDQ 3(5-6),149,1980
oral/rat toxic dose: 546 gm/kg/52W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TXAPA9 14,163,1969
oral/rat lowest published toxic dose: 431 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPTDQ 3(5-6),149,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 575 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/mouse lethal dose (50 percent kill): 1 gm/kgJJIND8 62,911,1979
intraperitoneal/rat lethal dose (50 percent kill): 10300 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 20,1242,1970
intravenous/chicken lowest published lethal dose: 33410 mg/kgARZNAD 20,1242,1970
intravenous/mouse lethal dose (50 percent kill): 10 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation
NYKZAU 64(1),42S,1968
intravenous/mouse lethal dose (50 percent kill): 10 gm/kgENTOX* -,17,2005
intravenous/rabbit lethal dose (50 percent kill): 7500 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation
NYKZAU 64(1),42S,1968
intravenous/rat lethal dose (50 percent kill): 10 gm/kgENTOX* -,17,2005
intravenous/rat lethal dose (50 percent kill): 12500 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation
NYKZAU 64(1),42S,1968
oral/mouse lethal dose (50 percent kill): 12900 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation
NYKZAU 64(1),42S,1968
oral/rat lethal dose (50 percent kill): 7 gm/kgJRPFA4 4,219,1962
subcutaneous/mouse lethal dose (50 percent kill): 8300 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)

Cardiac: Change in rate
OYYAA2 4,451,1970
subcutaneous/rat lethal dose (50 percent kill): 10 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)

Cardiac: Change in rate
OYYAA2 4,451,1970
unreported route/rat lethal dose (50 percent kill): 2300 mg/kgARZNAD 18,645,1968

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMSUDL 7,389,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1211,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 7,197,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1211,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1211,1999
TOXICOLOGY REVIEWCRTXB2 31,139,2001
TOXICOLOGY REVIEWENTOX* -,17,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWTXAPA9 243,180,2010
TOXICOLOGY REVIEWTXCYAC 286,1,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (25 mg/m3);short term exposure limit 25 ppm (60 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 25 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81686; Number of Industries 4; Total Number of Facilities 132; Number of Occupations 4; Total Number of Employees Exposed 2074; Total Number of Female Employees Exposed 1148
National Occupational Hazard Survey 1974Hazard Code 81686; Number of Industries 17; Total Number of Facilities 404; Number of Occupations 21; Total Number of Employees Exposed 4668

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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