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s - Triazole, 3 - amino -

RTECS #: XZ3850000

CAS #: 61-82-5


UPDATE: May 2009 MW: 84.10 MF: C2H4N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1H - 1,2,4 - Triazol - 3 - amine
  2. 3,A - T
  3. 3 - Amino - 1,2,4 - triazole
  4. 3 - Amino - 1,2,4 - triazole (ACGIH)
  5. 3 - Amino - 1H - 1,2,4 - triazole
  6. 3 - Amino - s - triazole
  7. 3 - Aminotriazole
  8. AT
  9. ATA
  10. Amino triazole weedkiller 90
  11. Aminotriazol - spritzpulver
  12. Aminotriazole (plant regulator)
  13. Amitol
  14. Amitrol
  15. Amitrol 90
  16. Amitrol - T
  17. Amitrole
  18. Amitrole (ACGIH)
  19. Amizol
  20. Campaprim A 1544
  21. Cytrol
  22. Cytrole
  23. Diurol
  24. Diurol 5030
  25. ENT 25445
  1. Elmasil
  2. Emisol
  3. Emisol 50
  4. Emisol F
  5. Herbidal total
  6. Herbizole
  7. Kleer - lot
  8. Orga - 414
  9. RCRA waste number U011
  10. Radoxone TL
  11. Ramizol
  12. Simazol
  13. Solution concentree T271
  14. Triazolamine
  15. USAF XR - 22
  16. Vorox
  17. Vorox AA
  18. Vorox AS
  19. Weedar ADS
  20. Weedar AT
  21. Weedazin
  22. Weedazin arginit
  23. Weedazol
  24. Weedex granulat
  25. X - All liquid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct Escherichia coli 10 mol/L MUREAV 89,95,1981
DNA damage Bacillus subtilis 1 mg/disc PMRSDJ 1,175,1981
DNA inhibition human fibroblast 100 mmol/L MUREAV 183,89,1987
DNA repair Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,502,1981
host-mediated assay mouse
Salmonella typhimurium
12 mg/kg JJIND8 62,911,1979
mutation in microorganisms Escherichia coli 50 g/plate (+enzymatic activation step) PMRSDJ 1,351,1981
mutation in microorganisms other microorganisms 1 mg/plate (-enzymatic activation step) MUREAV 57,277,1978
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) PMRSDJ 1,351,1981
mutation in microorganisms Saccharomyes cerevisiae 840 mg/L/16 hour MUTAEX 20,105,2004
gene conversion and mitotic recombination Aspergillus nidulans 600 g/L MUREAV 147,288,1985
gene conversion and mitotic recombination Saccharomyes cerevisiae 300 mg/L PMRSDJ 1,491,1981
mutation in mammalian somatic cells hamster embryo 1 mg/L MUREAV 140,205,1984
morphological transform hamster embryo 10 mg/L TOLED5 7,211,1981
morphological transform hamster kidney 250 mg/L PMRSDJ 1,638,1981
morphological transform mouse embryo 125 mg/L EMMUEG 12,21,1988
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform rat embryo 80 mg/L JJIND8 67,1303,1981
phage inhibition capacity Escherichia coli 15 gm/L VIRLAX 99,257,1979
sex chromosome loss and nondisjunction Aspergillus nidulans 600 g/L MUREAV 147,288,1985
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 50 mg/L PMRSDJ 1,468,1981
specific locus test oral
Drosophila melanogaster
500 mol/L MUREAV 242,169,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2,600 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ARTODN 33,41,1974
oral
mouse
lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160
oral
rat
lowest published toxic dose: 700 g/kg (22 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system ANREAK 145,284,1963
subcutaneous
mouse
lowest published toxic dose: 4,176 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 113 gm/kg/3 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JNCIAM 42,1101,1969
oral
mouse
toxic dose : 366 gm/kg/26 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
TOLED5 29,145,1985
oral
rat
lowest published toxic dose: 4,595 mg/kg/2.5 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
TXAPA9 69,161,1983
oral
rat
toxic dose : 3,670 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
SCIEAS 132,296,1960
oral
rat
toxic dose : 122 gm/kg/70 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
JNCIAM 57,861,1976
oral
rat
toxic dose : 105 gm/kg/60 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
NMJOAA 23,83,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD277-689
intravenous
mouse
lethal dose (50 percent kill): >5 gm/kg N/R OYYAA2 13,597,1977
oral
mouse
lethal dose (50 percent kill): 14,700 mg/kg N/R PCOC** -,33,1966
oral
quail
lethal dose (50 percent kill): >316 mg/kg N/R EESADV 6,149,1982
oral
rat
lethal dose (50 percent kill): 1,100 mg/kg N/R RREVAH 10,97,1965
skin
rat
lethal dose (50 percent kill): >10 gm/kg N/R WRPCA2 9,119,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
hamster
lowest published toxic dose: 4,704 mg/kg/28 week- continuous Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ARTODN 60,343,1987
oral
mouse
lowest published toxic dose: 14,070 mg/kg/3 week- continuous Blood: Changes in other cell count (unspecified) NSAPCC 375(Suppl 1),30,2007
oral
rat
lowest published toxic dose: 313 mg/kg/90 day- continuous Endocrine: Thyroid weight (goiter) JEPTDQ 1(1),147,1977
oral
rat
lowest published toxic dose: 300 mg/kg/3 day- continuous Endocrine: Other changes JOENAK 94,131,1982
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- continuous Endocrine: Thyroid weight (goiter) JOENAK 94,131,1982
oral
rat
lowest published toxic dose: 26,250 mg/kg/30 week- continuous Endocrine: Thyroid weight (goiter) JJIND8 57,861,1976
oral
rat
lowest published toxic dose: 61,250 mg/kg/70 week- continuous Endocrine: Tumors JJIND8 57,861,1976
oral
rat
lowest published toxic dose: 420 mg/kg/14 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 60,45,1981
oral
rat
lowest published toxic dose: 168 mg/kg/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 30,1,2005
oral
rat
lowest published toxic dose: 252 mg/kg/6 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thyroid weight
JTSCDR 30,1,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 7,31,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 7,31,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 79,-,2000
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
MUREAV 653,23,2008
TOXICOLOGY REVIEW
REPTED 25,304,2007
TOXICOLOGY REVIEW
HUTOX* -,551,1996
TOXICOLOGY REVIEW
HUTOX* -,551,1996
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,85,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, short term exposure limit 3 ppm, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.06 ppm (0.2 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.2 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m3, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO AMITROLE-air Carcinogen;
8 hour time-weighted average 0.2 mg/m3
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84718;
Number of Industries 3;
Total Number of Facilities 8;
Number of Occupations 4;
Total Number of Employees Exposed 693;
Total Number of Female Employees Exposed 24


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a herbicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HTOPA*
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NMJOAA Nagoya Medical Journal. (Nagoya City Univ. Medical School, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan) V.1- 1953-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 155-25-9
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