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s - Triazine, 2 - chloro - 4 - ethylamino - 6 - isopropylamino -

RTECS #: XY5600000

CAS #: 1912-24-9


UPDATE: May 2009 MW: 215.72 MF: C8H14ClN5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4 - diamine, 6 - chloro - N - ethyl - N' - (1 - methylethyl) - (9CI)
  2. 1 - Chloro - 3 - ethylamino - 5 - isopropylamino - 2,4,6 - triazine
  3. 1 - Chloro - 3 - ethylamino - 5 - isopropylamino - s - triazine
  4. 2 - Aethylamino - 4 - chlor - 6 - isopropylamino - 1,3,5 - triazin (German)
  5. 2 - Aethylamino - 4 - isopropylamino - 6 - chlor - 1,3,5 - triazin (German)
  6. 2 - Chloro - 4 - (2 - propylamino) - 6 - ethylamino - s - triazine
  7. 2 - Chloro - 4 - ethylamineisopropylamine - s - triazine
  8. 2 - Chloro - 4 - ethylamino - 6 - isopropylamino - 1,3,5 - triazine
  9. 2 - Chloro - 4 - ethylamino - 6 - isopropylamino - s - triazine
  10. 6 - Chloro - N - ethyl - N' - (1 - methylethyl) - 1,3,5 - triazine - 2,4 - diamine
  11. 6 - Chloro - N - ethyl - N9 - (1 - methylethyl) - 1,3,5 - triazine - 2,4 - diamine
  12. A 361
  13. Aatram 20G
  14. Aatrex
  15. Aatrex 4L
  16. Aatrex 80W
  17. Aatrex nine - O
  18. Aktikon
  19. Aktikon PK
  20. Aktinit A
  21. Aktinit PK
  22. Aneldazin
  23. Argezin
  24. Atrataf
  25. Atrazin
  26. Atrazine
  1. Atrazine (ACGIH)
  2. Azoprim
  3. Ceasin 50
  4. Cekuzina - T
  5. Chromozin
  6. Cyazin
  7. G 30027
  8. Geigy 30,027
  9. Gesaprim
  10. Herbatoxol
  11. Hungazin
  12. Hungazin PK
  13. Oleogesaprim
  14. Primatol A
  15. Radazin
  16. Technical atrazine
  17. Technical grade atrazine
  18. Triazine A 1294
  19. Vectal
  20. Vectal SC
  21. Weedex A
  22. Wonuk
  23. Zeapos
  24. Zeazin
  25. Zeazine
  26. Zeopos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
mammal (species unspecified)
100 mg severe VRDEA5 (5),133,1977
eye
rabbit
6,320 µg severe CIGET* -,-,1977
skin
mammal (species unspecified)
500 mg mild VRDEA5 (5),133,1977
skin
rabbit
38 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
hamster
5.0 µmol/L MUREAV 608,28,2006
cytogenetic analysis human lymphocyte 1 mg/L MUREAV 281,295,1992
cytogenetic analysis oral
mouse
72 mg/kg/30 day- continuous EMMUEG 19,77,1992
dominant lethal test parenteral
Drosophila melanogaster
556 µmol/L JTEHD6 3,691,1977
dominant lethal test oral
Drosophila melanogaster
100 ppm JTEHD6 3,691,1977
dominant lethal test oral
mouse
1,500 mg/kg MUREAV 74,77,1980
DNA damage human lymphocyte 100 mg/L MUREAV 344,41,1995
DNA damage intraperitoneal
mouse
500 mg/kg MUREAV 493,1,2001
DNA damage oral
rat
875 mg/kg MUREAV 209,145,1988
DNA damage oral
rat
2,100 mg/kg/7 day MUREAV 654,145,2008
unscheduled DNA synthesis human fibroblast 3 mmol/L MUREAV 74,77,1980
host-mediated assay mouse
Escherichia coli
100 mg/kg MUREAV 74,77,1980
host-mediated assay rat
Escherichia coli
100 mg/kg CECED9 6388,328,1980
mutation in microorganisms Aspergillus nidulans 6 mmol/L (+enzymatic activation step) MUREAV 74,77,1980
mutation in microorganisms hamster lung 3 mmol/L (+enzymatic activation step) MUREAV 74,77,1980
mutation in microorganisms Schizosaccharomyces pombe 6 mmol/L (+enzymatic activation step) MUREAV 74,77,1980
micronucleus test oral
rat
2,100 mg/kg/7 day MUREAV 654,145,2008
micronucleus test oral
rat
2,100 mg/kg MUREAV 654,145,2008
gene conversion and mitotic recombination Aspergillus nidulans 6 mmol/L MUREAV 74,77,1980
other mutation test systems oral
mouse
216 mg/kg/90 day- continuous EMMUEG 19,77,1992
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
100 ppm JTEHD6 3,691,1977
sex chromosome loss and nondisjunction Neurospora crassa 10 mg/L MUREAV 167,35,1986
specific locus test oral
Drosophila melanogaster
5 mmol/L MUREAV 280,291,1992
sperm morphology human sperm 100 µmol/L/1 hour REPTED 22,508,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1,028 mg/kg (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JJATDK 20,61,2000
oral
mouse
lowest published toxic dose: 29 mg/kg (14-21 day pregnant/1-21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral
REPTED 22,263,2006
oral
rat
lowest published toxic dose: 7 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 24,307,1988
oral
rat
lowest published toxic dose: 700 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 24,307,1988
oral
rat
lowest published toxic dose: 720 mg/kg (10 day prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral
APHHDU 83,79,1995
oral
rat
lowest published toxic dose: 125 mg/kg (5 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOSCF2 52,68,1999
oral
rat
lowest published toxic dose: 1,000 mg/kg (6-10 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,61,2000
oral
rat
lowest published toxic dose: 1,000 mg/kg (11-15 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,61,2000
oral
rat
lowest published toxic dose: 500 mg/kg (6-10 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 15,61,2000
oral
rat
lowest published toxic dose: 600 mg/kg (8-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 15,61,2000
oral
rat
lowest published toxic dose: 1,000 mg/kg (6-10 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 15,61,2000
oral
rat
lowest published toxic dose: 35 mg/kg (10 day pregnant-23 day after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOXID9 72,120,2003
oral
rat
lowest published toxic dose: 200 mg/kg (6-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 1,260 mg/kg (10-22 day pregnant/23 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
TOSCF2 76,366,2003
oral
rat
lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TXAPA9 195,23,2004
oral
rat
lowest published toxic dose: 300 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 44,230,2005
oral
rat
lowest published toxic dose: 700 mg/kg (13-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 44,230,2005
oral
rat
lowest published toxic dose: 300 mg/kg (15-17 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages TOXID9 78,218,2004
oral
rat
lowest published toxic dose: 300 mg/kg (17-19 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,218,2004
oral
rat
lowest published toxic dose: 700 mg/kg (13-19 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,218,2004
oral
rat
lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 66,371,2002
oral
rat
lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 66,373,2002
oral
rat
lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
TXAPA9 218,238,2007
oral
rat
lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Effects on newborn: Delayed effects TXAPA9 218,238,2007
oral
rabbit
lowest published toxic dose: 975 mg/kg (7-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 24,307,1988
oral
rabbit
lowest published toxic dose: 975 mg/kg (7-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 24,307,1988
subcutaneous
mouse
lowest published toxic dose: 418 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 588 mg/kg (10-21 day pregnant/9 day after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,10,2004
subcutaneous
mouse
lowest published toxic dose: 616,000 µg/kg (10 day pregnant-10 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXAPA9 214,69,2006
subcutaneous
rat
lowest published toxic dose: 2,400 mg/kg (3-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) BECTA6 9,301,1973
subcutaneous
rat
lowest published toxic dose: 6 gm/kg (3-9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BECTA6 9,301,1973
unreported route
rat
lowest published toxic dose: 125 mg/kg (5 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,116,2004
unreported route
rat
lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects TOXID9 60,391,2001
unreported route
rat
lowest published toxic dose: 875 mg/kg (14-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 90,190,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 9,000 mg/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159
oral
rat
lowest published toxic dose: 33,775 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Uterine tumors
NEOLA4 37,533,1990
oral
rat
lowest published toxic dose: 36.5 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 5,200 mg/m3/4 hour N/R FMCHA2 -,C29,1991
inhalation
rat
lethal concentration (50 percent kill): 700 mg/kg N/R ENTOX* -,188,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 626 mg/kg N/R PESTD5 17,351,1976
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Endocrine: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
TOXID9 72,172,2003
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Immunological Including Allergic: Decrease in humoral immune response TOXID9 60,24,2001
intraperitoneal
rat
lethal dose (50 percent kill): 235 mg/kg N/R PESTD5 17,351,1976
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg Liver: Other changes ETOPFR 12,1,2002
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TOXID9 44,400,2005
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Cardiac: Arrythmias (indlucing changes in conduction) TOXID9 90,304,2006
oral
hamster
lethal dose (50 percent kill): 1 gm/kg N/R TXAPA9 48,A192,1979
oral
mouse
lethal dose (50 percent kill): 850 mg/kg N/R 85GMAT -,36,1982
oral
mouse
lowest published toxic dose: 875 mg/kg Endocrine: Changes in thymus weight

Blood: Changes in spleen
TOXID9 72(Suppl 1),329,2003
oral
mouse
lowest published toxic dose: 8.75 mg/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 72(Suppl 1),329,2003
oral
rat
lethal dose (50 percent kill): 672 mg/kg N/R FAATDF 7,299,1986
oral
rat
lowest published toxic dose: 300 mg/kg Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
TOSCF2 53,297,2000
oral
rat
lowest published toxic dose: 40 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 200 mg/kg Endocrine: Androgenic

Endocrine: Estrogenic

Biochemical: Metabolism (intermediary): Other
TOXID9 78,117,2004
oral
rat
lethal dose (50 percent kill): 2 gm/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
ENTOX* -,188,2005
oral
rat
lowest published toxic dose: 75 mg/kg Endocrine: Adrenal cortex hyperplasia

Endocrine: Other changes
TOXID9 -,18,2008
oral
rabbit
lethal dose (50 percent kill): 750 mg/kg N/R ENTOX* -,188,2005
skin
rat
lethal dose (50 percent kill): >12,500 mg/kg N/R GISAAA 55(7),87,1990
skin
rat
lethal dose (50 percent kill): 3 gm/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
ENTOX* -,188,2005
skin
rabbit
lethal dose (50 percent kill): 7,500 mg/kg N/R 28ZEAL 5,15,1976
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 1,400 mg/kg N/R GISAAA 44(6),81,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 mg/m3/26 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
KHZDAN 12,114,1969
intraperitoneal
rat
lowest published toxic dose: 360 mg/kg/23 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 20,61,2000
intraperitoneal
rat
lowest published toxic dose: 1,020 mg/kg/60 day- intermittent Endocrine: Changes in pituitary weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight
JAPTO* 20,61,2000
intraperitoneal
rat
lowest published toxic dose: 2,040 mg/kg/60 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct JAPTO* 20,61,2000
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
ETOPFR 12,1,2002
oral
dog
lowest published toxic dose: 9,125 mg/kg/1 year- continuous Cardiac: Changes in coronary arteries

Cardiac: Pulse rate increased without fall in BP

Cardiac: Other changes
NTIS** OTS0543210
oral
dog
lowest published toxic dose: 9,100 mg/kg/52 week- intermittent Cardiac: Other changes HBPTO* 2,1512,2001
oral
mouse
lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Liver: Changes in liver weight AECTCV 24,449,1993
oral
mouse
lowest published toxic dose: 20.8 gm/kg/78 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
mouse
lowest published toxic dose: 350 mg/kg/14 day- intermittent Endocrine: Changes in spleen weight TXCYAC 209,15,2005
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 209,15,2005
oral
mouse
lowest published toxic dose: 7,000 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 209,15,2005
oral
mouse
lowest published toxic dose: 1,750 mg/kg/14 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TOXID9 44,400,2005
oral
mouse
lowest published toxic dose: 109.2 mg/kg/26 week- intermittent Biochemical: Metabolism (intermediary): Other

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 90,304,2006
oral
mouse
lowest published toxic dose: 7,000 mg/kg/14 day- intermittent Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Increase in cellular immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-94003
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Behavioral: Alteration of classical conditioning

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
NTPTR* IMM-94003
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Blood: Changes in spleen NTPTR* IMM-94003
oral
mouse
lowest published toxic dose: 4,000 mg/kg/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* IMM-94002
oral
mouse
lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
NTPTR* IMM-94002
oral
mouse
lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-94002
oral
mouse
lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Immunological Including Allergic: Increase in humoral response NTPTR* IMM-94002
oral
mouse
lowest published toxic dose: 375 mg/kg/15 day- intermittent Blood: Changes in other cell count (unspecified) NTPTR* IMM-94002
oral
pig
lowest published toxic dose: 38 mg/kg/19 day- intermittent Endocrine: Change in LH

Endocrine: Effect on menstrual cycle
TOLED5 85,9,1996
oral
pig
lowest published toxic dose: 20 mg/kg/20 day- continuous Endocrine: Change in LH

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXAPA9 197,351,2004
oral
rat
lowest published toxic dose: 6 gm/kg/30 day- intermittent Endocrine: Other changes

Related to Chronic Data: Changes in prostate weight
TOXID9 54,366,2000
oral
rat
lowest published toxic dose: 33,572 mg/kg/22 week- intermittent Liver: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
KHZDAN 12,114,1969
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
BECTA6 36,325,1986
oral
rat
lowest published toxic dose: 4,200 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JJATDK 7,373,1987
oral
rat
lowest published toxic dose: 3,825 mg/kg/21 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders REPTED 10,257,1996
oral
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Endocrine: Other changes TOSCF2 52,68,1999
oral
rat
lowest published toxic dose: 125 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 15,61,2000
oral
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 15,61,2000
oral
rat
lowest published toxic dose: 3,150 mg/kg/21 day- intermittent Endocrine: Change in LH

Endocrine: Other changes
TOSCF2 53,297,2000
oral
rat
lowest published toxic dose: 1,575 mg/kg/21 day- intermittent Endocrine: Change in LH TOSCF2 53,297,2000
oral
rat
lowest published toxic dose: 900 mg/kg/3 day- intermittent Reproductive: Maternal effects: Oogenesis TOSCF2 53,297,2000
oral
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,135,2000
oral
rat
lowest published toxic dose: 800 mg/kg/8 day- intermittent Endocrine: Change in LH

Endocrine: Other changes

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TOSCF2 58,135,2000
oral
rat
lowest published toxic dose: 800 mg/kg/8 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,135,2000
oral
rat
lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Endocrine: Estrogenic TOSCF2 58,135,2000
oral
rat
lowest published toxic dose: 145,600 mg/kg/104 week- continuous Endocrine: Tumors

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
HBPTO* 1,738,2001
oral
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Endocrine: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
HBPTO* 1,738,2001
oral
rat
lowest published toxic dose: 98 mg/kg/4 week- continuous Endocrine: Effect on menstrual cycle JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 7,280 mg/kg/52 week- continuous Skin and Appendages: Other: Breast JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 43,155,1994
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
JTEHD6 43,155,1994
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Endocrine: Estrogenic

Endocrine: Effect on menstrual cycle

Blood: Other changes
JTEHD6 43,155,1994
oral
rat
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Endocrine: Other changes

Blood: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina
JTEHD6 43,155,1994
oral
rat
lowest published toxic dose: 600 mg/kg/2 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Tumorigenic: Cells (cultured) transformed
JTEHF8 43,183,1994
oral
rat
lowest published toxic dose: 2,970 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat
lowest published toxic dose: 14.6 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Endocrine: Androgenic REPTED 16,275,2002
oral
rat
lowest published toxic dose: 1,350 mg/kg/27 day- intermittent Endocrine: Androgenic REPTED 16,275,2002
oral
rat
lowest published toxic dose: 420 mg/kg/7 day- intermittent Endocrine: Androgenic JSTBBK 33,141,1989
oral
rat
lowest published toxic dose: 300 mg/kg/3 day- intermittent Blood: Changes in leukocyte (WBC) count HBPTO* 1,777,2001
oral
rat
lowest published toxic dose: 1,440 mg/kg/6 day- intermittent Endocrine: Evidence of thyroid hypofunction BESCE5 9,60,1996
oral
rat
lowest published toxic dose: 318.5 mg/kg/13 week- continuous Endocrine: Estrogenic JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 5,460 mg/kg/39 week- continuous Endocrine: Other changes JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 910 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 14,700 mg/kg/105 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 105 mg/kg/30 day- continuous Endocrine: Effect on menstrual cycle JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 315 mg/kg/90 day- continuous Endocrine: Estrogenic JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 800 mg/kg/40 week- continuous Endocrine: Change in gonadotropins JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 14,700 mg/kg/105 week- continuous Endocrine: Tumors JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 7,280 mg/kg/52 week- continuous Endocrine: Tumors JTEHD6 43,169,1994
oral
rat
lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Endocrine: Change in LH TOXID9 72,133,2003
oral
rat
lowest published toxic dose: 1,572.2 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,1811,2003
oral
rat
lowest published toxic dose: 18.87 gm/kg/24 week- continuous Behavioral: Food intake (animal)

Brain and Coverings: Changes in brain weight

Related to Chronic Data: Changes in testicular weight
FCTOD7 41,1811,2003
oral
rat
lowest published toxic dose: 900 mg/kg/9 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
RTOPDW 35,468,2002
oral
rat
lowest published toxic dose: 750 mg/kg/25 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina RTOPDW 35,468,2002
oral
rat
lowest published toxic dose: 800 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 195,177,2004
oral
rat
lowest published toxic dose: 300 mg/kg/3 day- intermittent Behavioral: Alteration of classical conditioning TOXID9 44,230,2005
oral
rat
lowest published toxic dose: 800 mg/kg/4 day- intermittent Endocrine: Estrogenic

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other
TOXID9 78,117,2004
oral
rat
lowest published toxic dose: 4,200 mg/kg/21 day- intermittent Endocrine: Estrogenic

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other
TOXID9 78,117,2004
oral
rat
lowest published toxic dose: 18.75 mg/kg/3 day- intermittent Endocrine: Change in LH TOXID9 44,353,2005
oral
rat
lowest published toxic dose: 225 mg/kg/3 day- intermittent Endocrine: Other changes TOXID9 44,353,2005
oral
rat
lowest published toxic dose: 910 mg/kg/0.5 year- continuous Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites TOXID9 78,277,2004
oral
rat
lowest published toxic dose: 1,820 mg/kg/0.5 year- continuous Behavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 78,277,2004
oral
rat
lowest published toxic dose: 3,640 mg/kg/0.5 year- continuous Endocrine: Change in LH TOXID9 60,321,2001
oral
rat
lowest published toxic dose: 400 mg/kg/4 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 -,271,2008
oral
rat
lowest published toxic dose: 50 mg/kg/4 day- intermittent Endocrine: Adrenal cortex hyperplasia TOXID9 -,18,2008
oral
rat
lowest published toxic dose: 300 mg/kg/4 day- intermittent Endocrine: Adrenal cortex hyperplasia

Endocrine: Other changes
TOXID9 -,18,2008
oral
rat
lowest published toxic dose: 800 mg/kg/4 day- intermittent Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 12,471,2008
subcutaneous
rat
lowest published toxic dose: 45 mg/kg/3 week- intermittent Gastrointestinal: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other
LIFSAK 69,901,2001
skin
rabbit
lowest published toxic dose: 25 gm/kg/25 day- continuous Blood: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0555001
unreported route
rat
lowest published toxic dose: 840 mg/kg/7 day- continuous Endocrine: Effect on menstrual cycle HBPTO* 1,738,2001
unreported route
rat
lowest published toxic dose: 1,575 mg/kg/21 day- continuous Endocrine: Estrogenic

Endocrine: Other changes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
HBPTO* 1,738,2001
unreported route
rat
lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Endocrine: Change in LH

Endocrine: Estrogenic
TOXID9 66,339,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 53,441,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,59,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,441,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,59,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,59,1999
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,188,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 23,337,2007
TOXICOLOGY REVIEW
MUREAV 544,305,2003
TOXICOLOGY REVIEW
FEREAC 72,32570,2007
TOXICOLOGY REVIEW
FEREAC 72,53449,2007
TOXICOLOGY REVIEW
FEREAC 72,32570,2007
TOXICOLOGY REVIEW
FEREAC 72,53449,2007
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
HUTOX* -,551,1996
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,87,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 2 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ATRAZINE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18420;
Number of Industries 1;
Total Number of Facilities 165;
Number of Occupations 2;
Total Number of Employees Exposed 331
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18420;
Number of Industries 1;
Total Number of Facilities 44;
Number of Occupations 9;
Total Number of Employees Exposed 1,001;
Total Number of Female Employees Exposed 123


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100001)
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for season-long weed control in corn, sorghum and certain other crops
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8894
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
APHHDU Acta Physiologica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) V.61- 1983-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BESCE5 Biomedical and Environmental Sciences. (Academic Press, 525 B St., Suite 1900, San Diego, CA 92101) V.1- 1988-
CECED9 Commission of the European Communities, Report EUR. (Office for Official Pub., 5 rue du Commerce, Luxembourg L-2985, Luxembourg) 1967-
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
ITODC*
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1918-

Used for season-long weed control in corn, sorghum and certain other crops

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 11121-31-6
ALT CAS #: 12040-45-8
ALT CAS #: 12797-72-7
ALT CAS #: 39400-72-1
ALT CAS #: 69771-31-9
ALT CAS #: 93616-39-8
Click Here for Additional Information about RTECS

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