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m - Toluidine

RTECS #: XU2800000

CAS #: 108-44-1


UPDATE: May 2009 MW: 107.17 MF: C7H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Amino - 1 - methylbenzene
  2. 3 - Aminophenylmethane
  3. 3 - Aminotoluen (Czech)
  4. 3 - Aminotoluene
  5. 3 - Methylaniline
  6. 3 - Methylbenzenamine
  7. 3 - Toluidine
  8. Aniline, 3 - methyl -
  1. Benzenamine, 3 - methyl - (9CI)
  2. m - Aminotoluene
  3. m - Methylaniline
  4. m - Methylbenzenamine
  5. m - Toluidin (Czech)
  6. m - Toluidine (ACGIH)
  7. m - Toluidyna (Polish)
  8. m - Tolylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,459,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,459,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 116 mg/kg N/R AISFAR 1,284,1951
oral
wild bird
lethal dose (50 percent kill): 242 mg/kg N/R AECTCV 12,355,1983
oral
cat
lethal dose (50 percent kill): >50 mg/kg N/R NTIS** OTS0573041
oral
mouse
lethal dose (50 percent kill): 740 mg/kg N/R ENTOX* -,206,2005
oral
rat
lethal dose (50 percent kill): 450 mg/kg N/R ENTOX* -,206,2005
oral
rabbit
lethal dose (50 percent kill): 750 mg/kg N/R VINIT* #4035-77
skin
rabbit
lethal dose (50 percent kill): 3,250 mg/kg N/R NTIS** OTS0573041


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 8,400 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VINIT* #4035-77
oral
rat
lowest published toxic dose: 1,722 mg/kg/6 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain IJTOFN 24,365,2005
oral
rat
lowest published toxic dose: 1,230 mg/kg/30 day- continuous Liver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJTOFN 24,365,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,206,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (8.8 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (8.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (9 mg/m3), OCT 2002
Occupational Exposure Limit - HUNGARY time-weighted average 9 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (9 mg/m3), skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 9 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (8.8 mg/m3), skin, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (9 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81889;
Number of Industries 3;
Total Number of Facilities 257;
Number of Occupations 3;
Total Number of Employees Exposed 2,876


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as dye intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AISFAR Archivio Italiano di Scienze Farmacologiche. (Modena, Italy) V.1-11, 1932-42; Series 2: V.1-3, 1948-50; Series 3: V.1-15, 1951-65. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.

Used as dye intermediate

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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