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Succinic acid, mercapto - , diethyl ester, S - ester with O,O - dimethylphosphorodithioate

RTECS #: WM8400000

CAS #: 121-75-5


UPDATE: May 2009 MW: 330.38 MF: C10H19O6PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. ( (Dimethoxyphosphinothioyl) thio) butanedioic acid diethyl ester
  2. 1,2 - Di (ethoxycarbonyl) ethyl O,O - dimethyl phosphorodithioate
  3. American cyanamid 4,049
  4. Carbethoxy malathion
  5. Carbetovur
  6. Carbetox
  7. Carbofos
  8. Carbophos
  9. Chemathion
  10. Cimexan
  11. Compound 4049
  12. Cythion
  13. Detmol MA
  14. Detmol MA 96%
  15. Dicarboethoxyethyl O,O - dimethyl phosphorodithioate
  16. Diethyl ( (dimethoxyphosphinothioyl) thio) butanedioate
  17. Diethyl (dimethoxyphosphinothioylthio) succinate
  18. Diethyl mercaptosuccinate S - ester with O,O - dimethylphosphorodithioate
  19. Diethyl mercaptosuccinate, O,O - dimethyl dithiophosphate, S - ester
  20. Diethyl mercaptosuccinate, O,O - dimethyl phosphorodithioate
  21. Diethyl mercaptosuccinate, O,O - dimethyl thiophosphate
  22. Diethyl mercaptosuccinic acid O,O - dimethyl phosphorodithioate
  23. Dithiophosphate de O,O - dimethyle et de S - (1,2 - dicarboethoxyethyle) (French)
  24. EL 4049
  25. ENT 17,034
  26. Emmatos
  27. Emmatos Extra
  28. Ethiolacar
  29. Etiol
  30. Experimental insecticide 4049
  31. Extermathion
  32. Forthion
  33. Fosfothion
  34. Fosfotion
  35. Fosfotion 550
  36. Fyfanon
  37. Hilthion
  38. Hilthion 25WDP
  39. Insecticide No. 4049
  40. Karbofos
  41. Kop - thion
  42. Kypfos
  43. Latka 4049 (Czech)
  44. Malacide
  45. Malafor
  46. Malagran
  47. Malakill
  48. Malamar
  49. Malamar 50
  50. Malaphele
  51. Malaphos
  52. Malasol
  53. Malaspray
  1. Malathion
  2. Malathion (ACGIH:OSHA)
  3. Malathion E50
  4. Malathion LV concentrate
  5. Malathion ULV concentrate
  6. Malathon
  7. Malathyl LV concentrate & ULV concentrate
  8. Malation (Polish)
  9. Malatol
  10. Malatox
  11. Maldison
  12. Malmed
  13. Malphos
  14. Maltox
  15. Maltox MLT
  16. Mercaptosuccinic acid diethyl ester
  17. Mercaptothion
  18. Mercaptotion (Spanish)
  19. Moscarda
  20. NCI - C00215
  21. O,O - Dimethyl S - (1,2 - bis (ethoxycarbonyl) ethyl) dithiophosphate
  22. O,O - Dimethyl S - (1,2 - dicarbethoxyethyl) dithiophosphate
  23. O,O - Dimethyl S - (1,2 - dicarbethoxyethyl) thiothionophosphate
  24. O,O - Dimethyl S - (1,2 - dicarbethoxyethyl) phosphorodithioate
  25. O,O - Dimethyl S - 1,2 - di (ethoxycarbamyl) ethyl phosphorodithioate
  26. O,O - Dimethyl - S - 1,2 - (dicarbaethoxyaethyl) - dithiophosphat (German)
  27. O,O - Dimethyl - S - 1,2 - dikarbetoxylethylditiofosfat (Czech)
  28. O,O - Dimethyldithiophosphate diethylmercaptosuccinate
  29. O,O - Dwumetylo - S - 1,2 - bis (karboetoksyetylo) - dwutiofosforan (Polish)
  30. Oleophosphothion
  31. Ortho malathion
  32. Phosphorodithioic acid, O,O - dimethyl ester, S - ester with diethyl mercaptosuccinate
  33. Phosphothion
  34. Prentox malathion 95% spray
  35. Prioderm
  36. S - (1,2 - Bis (aethoxy - carbonyl) - aethyl) - O,O - dimethyl - dithiophosphat (German)
  37. S - (1,2 - Bis (carbethoxy) ethyl) O,O - dimethyl dithiophosphate
  38. S - (1,2 - Bis (ethoxy - carbonyl) - ethyl) - O,O - dimethyl - dithiofosfaat (Dutch)
  39. S - (1,2 - Bis (ethoxycarbonyl) ethyl) O,O - dimethyl phosphorodithioate
  40. S - (1,2 - Bis (etossi - carbonil) - etil) - O,O - dimetil - ditiofosfato (Italian)
  41. S - (1,2 - Di (ethoxycarbonyl) ethyl) dimethyl phosphorothiolothionate
  42. S - (1,2 - Dicarbethoxyethyl) O,O - dimethyldithiophosphate
  43. S - 1,2 - Bis (ethoxycarbonyl) ethyl - O,O - dimethyl thiophosphate
  44. SF 60
  45. Sadofos
  46. Sadophos
  47. Siptox I
  48. Sumitox
  49. TAK
  50. TM - 4049
  51. Vegfru malatox
  52. Vetiol
  53. Zithiol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster
240 mg/kg ARTODN 58,152,1986
cytogenetic analysis hamster lung 76 mg/L GMCRDC 27,95,1981
cytogenetic analysis hamster ovary 303 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis human lymphocyte 50 mg/L CYTOAN 54,191,1989
cytogenetic analysis human leukocyte 2 mg/L MUREAV 301,13,1993
cytogenetic analysis mammal (species unspecified) lymphocyte 25 mg/L CUSCAM 57,280,1988
cytogenetic analysis oral
mouse
14 mg/kg/7 day- continuous FCTOD7 33,309,1995
cytogenetic analysis skin
mouse
500 mg/kg MUREAV 204,283,1988
cytogenetic analysis oral
mouse
121 mg/kg/12 week MUREAV 513,1,2002
cytogenetic analysis intraperitoneal
mouse
5 mg/kg MUREAV 514,223,2002
cytogenetic analysis oral
mouse
5 mg/kg MUREAV 514,223,2002
cytogenetic analysis oral
mouse
10 mg/kg/5 day MUREAV 514,223,2002
cytogenetic analysis multiple
other fish
200 nL/L JFIBA9 26,13,1985
dominant lethal test oral
Drosophila melanogaster
2,500 ng/L FCTOD7 33,309,1995
DNA damage Escherichia coli 100 mg/L MUREAV 52,161,1978
DNA inhibition human lymphocyte 70 mg/L HUGEDQ 53,375,1980
unscheduled DNA synthesis human lymphocyte 10 mg/L HUGEDQ 56,189,1980
mutation in microorganisms Bacillus subtilis 1 nmol/plate (-enzymatic activation step) MSERDS 5,93,1981
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) CYGEDX 15(3),64,1981
mutation in microorganisms Salmonella typhimurium 10 mg/L (+enzymatic activation step) CYGEDX 15(3),64,1981
micronucleus test human lymphocyte 75 mg/L MUREAV 388,85,1997
other mutation test systems human lymphocyte 10 mg/L HUGEDQ 56,189,1980
other mutation test systems human lymphocyte 70 mg/L ENVRAL 41,372,1986
other mutation test systems human leukocyte 20 g/L MUREAV 301,13,1993
other mutation test systems mammal (species unspecified) lymphocyte 50 mg/L CUSCAM 57,280,1988
other mutation test systems skin
mouse
1 gm/kg MUREAV 204,283,1988
sister chromatid exchange hamster ovary 300 mol/L JTEHD6 8,939,1981
sister chromatid exchange hamster lung 40 mg/L MUREAV 88,307,1981
sister chromatid exchange human lymphocyte 20 mg/L CYTOAN 54,191,1989
sister chromatid exchange human fibroblast 5 mg/L MUREAV 67,167,1979
sister chromatid exchange human leukocyte 20 mg/L MUREAV 301,13,1993
sister chromatid exchange oral
mouse
121 mg/kg/12 week MUREAV 513,1,2002
sister chromatid exchange intraperitoneal
mouse
5 mg/kg MUREAV 514,223,2002
sister chromatid exchange oral
mouse
10 mg/kg/5 day MUREAV 514,223,2002
specific locus test oral
Drosophila melanogaster
4 g/L FCTOD7 33,309,1995
sperm morphology human sperm 50 mol/L/1 hour REPTED 22,508,2006
sperm morphology intraperitoneal
mouse
5 mg/kg MUREAV 514,223,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 5,550 mg/kg (91 day prior to copulation/1-20 day pregnant) Reproductive: Specific developmental abnormalities: Body wall JTEHD6 14,267,1984
oral
rat
lowest published toxic dose: 43,920 mg/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
NATUAS 192,464,1961
oral
rat
lowest published toxic dose: 191 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JFMAAQ 54,452,1967
oral
rat
lowest published toxic dose: 283 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JFMAAQ 54,452,1967
oral
rat
lowest published toxic dose: 20 mg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FATOAO 52,87,1989
oral
rat
lowest published toxic dose: 40 mg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects FATOAO 52,87,1989
oral
rabbit
lowest published toxic dose: 540 mg/kg (28-30 day pregnant) Reproductive: Other effects to embryo or fetus MSCREJ 17,743,1989
subcutaneous
mouse
lowest published toxic dose: 420 mg/kg (1-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 27,1101,2006
unreported route
rat
lowest published toxic dose: 80 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BECTA6 15,458,1976
unreported route
rat
lowest published toxic dose: 40 mg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
FATOAO 54,80,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraarterial
cat
lowest published lethal dose: 1,820 g/kg N/R 14KTAK -,693,1964
inhalation
cat
lowest published lethal concentration: 10 mg/m3/4 hour N/R 85GMAT -,56,1982
inhalation
rat
lethal concentration (50 percent kill): 43,790 g/m3/4 hour N/R GISAAA 56(2),80,1991
intraperitoneal
dog
lethal dose (50 percent kill): 1,857 mg/kg N/R TXAPA9 15,244,1969
intraperitoneal
guinea pig
lethal dose (50 percent kill): 271 mg/kg N/R AEPPAE 236,202,1959
intraperitoneal
hamster
lethal dose (50 percent kill): 2,400 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 193 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat
lethal dose (50 percent kill): 250 mg/kg N/R ARZNAD 22,1926,1972
intravenous
man
lowest published toxic dose: 14 L/kg Vascular: Other changes

Skin: After systemic exposure: Dermatitis, other
JJAMA* 16,367,1992
intravenous
mouse
lethal dose (50 percent kill): 184 mg/kg N/R BLLIAX 38,151,1958
intravenous
rat
lethal dose (50 percent kill): 50 mg/kg N/R ARZNAD 5,626,1955
oral
wild bird
lethal dose (50 percent kill): 400 mg/kg N/R AECTCV 12,355,1983
oral
chicken
lethal dose (50 percent kill): 600 mg/kg Behavioral: Food intake (animal) IJEBA6 9,455,1971
oral
chicken
lethal dose (50 percent kill): 1,000 mg/kg N/R HBPTO* 2,957,2001
oral
cattle
lethal dose (50 percent kill): 53 mg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy)
IVEJAC 56,650,1979
oral
duck
lethal dose (50 percent kill): 1,485 g/kg N/R DOEAAH 35,25,1979
oral
domestic animal
lethal dose (50 percent kill): 500 mg/kg N/R 85DPAN -,-,1971/1976
oral
guinea pig
lethal dose (50 percent kill): 570 mg/kg N/R ARZNAD 5,626,1955
oral
man
lowest published lethal dose: 471 mg/kg Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea
ATXKA8 23,11,1967
oral
mouse
lethal dose (50 percent kill): 190 mg/kg N/R 85GMAT -,56,1982
oral
rat
lethal dose (50 percent kill): 290 mg/kg N/R 85GMAT -,56,1982
oral
rat
lethal dose (50 percent kill): 644 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FATOAO 53,64,1990
oral
rat
lowest published toxic dose: 100 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOSCF2 92,235,2006
oral
rat
lowest published toxic dose: 500 mg/kg Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral
rat
lethal dose (50 percent kill): 450 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
oral
rat
lowest published toxic dose: 360 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Hemorrhage

Blood: Methemoglobinemia- Carboxhemoglobinemia
TPKVAL 7,122,1965
oral
rat
lowest published toxic dose: 100 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 250,27,2008
oral
rabbit
lowest published lethal dose: 1,200 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation AEHA** 99-002-74/1976
oral
woman
lowest published lethal dose: 8 mL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes
FSINDR 95,89,1998
oral
woman
lowest published toxic dose: 200 L/kg Behavioral: Coma

Gastrointestinal: Changes in structure or function of exocrine pancreas

Lung, Thorax, or Respiration: Respiratory depression
IJMDAI 30,855,1994
oral
woman
lowest published lethal dose: 246 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Skin: After systemic exposure: Dermatitis, other
AEHLAU 33,240,1978
oral
woman
lowest published toxic dose: 300 L/kg Behavioral: Coma

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Cyanosis
HETOEA 13,271,1994
subcutaneous
guinea pig
lethal dose (50 percent kill): 450 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous
guinea pig
lethal dose (50 percent kill): 450 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous
guinea pig
lowest published toxic dose: 112.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TPKVAL 7,122,1965
subcutaneous
mouse
lethal dose (50 percent kill): 221 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase OIZAAV 71,6099,1959
subcutaneous
mouse
lowest published toxic dose: 1,000 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 29,184,2008
subcutaneous
rat
lethal dose (50 percent kill): 400 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous
rat
lethal dose (50 percent kill): 400 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous
rabbit
lethal dose (50 percent kill): 280 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous
rabbit
lethal dose (50 percent kill): 280 mg/kg Kidney, Ureter, and Bladder: Urine volume increased

Endocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
skin
guinea pig
lethal dose (50 percent kill): 6,700 mg/kg N/R AMCYC* 8/1966
skin
mouse
lethal dose (50 percent kill): 2,330 mg/kg N/R ABCHA6 27,684,1963
skin
rat
lethal dose (50 percent kill): >4,444 mg/kg N/R PMJMAQ -,155,1957
skin
rabbit
lethal dose (50 percent kill): 4,100 mg/kg N/R 28ZEAL 5,142,1976
unreported route
cattle
lethal dose (50 percent kill): 53 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)
IJLAA4 49,314,1979
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,357,1971
unreported route
mammal (species unspecified)
lowest published toxic dose: 715 mg/kg Immunological Including Allergic: Decrease in cellular immune response

Blood: Changes in cell count (unspecified)
HBPTO* 1,773,2001
unreported route
mammal (species unspecified)
lowest published toxic dose: 0.25 mg/kg Immunological Including Allergic: Decrease in cellular immune response HBPTO* 1,773,2001
unreported route
mouse
lethal dose (50 percent kill): 375 mg/kg N/R GISAAA 50(3),4,1985
unreported route
rat
lethal dose (50 percent kill): 124 mg/kg N/R HBPTO* 1,786,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,300 g/m3/4 hour/13 week- intermittent Endocrine: Other changes

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(8),93,1976
intraperitoneal
rat
lowest published toxic dose: 1,050 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport
PHTOEH 61,12,1987
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOSCF2 97,140,2007
multiple
non-mammalian species
: 500 mg/m3/7 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXCYAC 212,107,2005
oral
dog
lowest published toxic dose: 210 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FCTXAV 6,185,1968
oral
dog
lowest published toxic dose: 175 mg/kg/4 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPETAB 121,96,1957
oral
domestic animal
lowest published toxic dose: 150 mg/kg/6 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VHTODE 41,287,1999
oral
human
lowest published toxic dose: 19.04 mg/kg/56 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral
mouse
lowest published toxic dose: 504 mg/kg/12 week- continuous Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 36,273,1998
oral
mouse
lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
BECTA6 63,575,1999
oral
rat
lowest published toxic dose: 900 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JDGRAX 18,145,1989
oral
rat
lowest published toxic dose: 462 mg/kg/22 week- continuous Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 36,273,1998
oral
rat
lowest published toxic dose: 2,250 mg/kg/45 day- intermittent Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
BECTA6 33,289,1984
oral
rat
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
AECTCV 14,459,1985
oral
rat
lowest published toxic dose: 3,358 mg/kg/14 day- continuous Behavioral: Fluid intake

Blood: Change in clotting factors
JEPOEC 6(1),51,1985
oral
rat
lowest published toxic dose: 288 mg/kg/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
rat
lowest published toxic dose: 3,285 mg/kg/730 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral
rat
lowest published toxic dose: 140 mg/kg/2 week- intermittent Endocrine: Change in gonadotropins

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BECTA6 18,231,1977
oral
rat
lowest published toxic dose: 168 mg/kg/4 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Lipids including transport
CBCPAI 137,29,2004
oral
rat
lowest published toxic dose: 168 mg/kg/4 week- continuous Liver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Glycolytic
CBCPAI 137,343,2004
oral
rat
lowest published toxic dose: 3,200 mg/kg/32 day- intermittent Behavioral: Food intake (animal)

Liver: Other changes

Liver: Changes in liver weight
TXCYAC 223,9,2006
oral
rabbit
lowest published toxic dose: 368 mg/kg/21 week- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 36,273,1998
subcutaneous
guinea pig
lowest published toxic dose: 18,900 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
guinea pig
lowest published toxic dose: 1,125 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
mouse
lowest published toxic dose: 4,200 mg/kg/21 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase NRTXDN 27,1101,2006
subcutaneous
rat
lowest published toxic dose: 16,800 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TPKVAL 7,122,1965
subcutaneous
rabbit
lowest published toxic dose: 11,760 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous
rabbit
lowest published toxic dose: 2,100 mg/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 7,122,1965
skin
rat
lowest published toxic dose: 1,332 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes TOXID9 78,86,2004
skin
rat
lowest published toxic dose: 1,332 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)
JTEHF8 67,331,2004
unreported route
rat
lowest published toxic dose: 5.6 gm/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1035,2001
unreported route
rabbit
lowest published toxic dose: 1,750 mg/kg/5 week- intermittent Immunological Including Allergic: Decrease in humoral immune response HBPTO* 1,773,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,103,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,103,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
PMDCAY 10,85,1974
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
JTCTDW 38,47,2000
TOXICOLOGY REVIEW
MUREAV 562,77,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
NETOX* 26,531,2005
TOXICOLOGY REVIEW
NRTXDN 27,628,2006
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
ENTOX* -,306,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,128,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 (skin) DTLVS* 3,148,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3 (skin), total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3 (skin), total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3 (skin), total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 15 mg/m3 (inhalable), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3 (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALATHION-air 10 hour time-weighted average 10 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80046;
Number of Industries 13;
Total Number of Facilities 1,609;
Number of Occupations 14;
Total Number of Employees Exposed 17,242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80046;
Number of Industries 15;
Total Number of Facilities 2,146;
Number of Occupations 18;
Total Number of Employees Exposed 19,170;
Total Number of Female Employees Exposed 1,909


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100003)
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as a broad spectrum insecticide and acaricide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-192,1979
OSHA ANALYTICAL METHOD #ID-62


REFERENCES:

CODEN
REFERENCE

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHA** U.S. Army, Environmental Hygiene Agency Reports. (Edgewood Arsenal, MD 21010)
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AMCYC* Toxicological Information on Cyanamid Insecticides. (American Cyanamid Co., Agricultural Div., Princeton, NJ 08540)
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932-
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FSINDR Forensic Science International. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.12- 1978-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HTOPA*
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.31- 1976-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IJLAA4 Indian Journal of Animal Sciences. (Indian Council of Agricultural Research, Krishi Bhavan, New Delhi 110 001, India) V.39- 1969-
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITODC*
IVEJAC Indian Veterinary Journal. (Dr. R. Krishnamurti, G.M.V.C., 8 Avenue Rd., Madras 600 034, India) V.1- 1924-
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JFIBA9 Journal of Fish Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
JFMAAQ Journal of the Florida Medical Association. (Florida Medical Assoc., POB 2411, Jacksonville, FL 32203) V.1- 1914-
JJAMA* Japanese Journal of Acute Medicine. (Nihon Kyukyu Igakkai Jun Kikanshi, Herusu Shuppan, 2-3 Nakano 2-chome, Nakanoku Tokyo 164, Japan) V.1- 196(?)-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
MSERDS Microbiology Series. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETOX* NeuroToxicology (Amsterdam : Elsevier Science) V.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
OIZAAV Osaka Igaku Zasshi. (Osaka, Japan)
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961-
PMJMAQ Proceedings of the Annual Meeting of the New Jersey Mosquito Extermination Association. (New Brunswick, NJ) V.1-61, 1914-74.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
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TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as a broad spectrum insecticide and acaricide

FDA-proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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