CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Styrene, alpha - methyl -

RTECS #: WL5075300

CAS #: 98-83-9


UPDATE: May 2009 MW: 118.19 MF: C9H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 1 - phenylethylene
  2. 2 - Phenylpropene
  3. 2 - Phenylpropylene
  4. Benzene, (1 - methylethenyl) -
  5. Isopropenil - benzolo (Italian)
  6. Isopropenyl - benzeen (Dutch)
  7. Isopropenyl - benzol (German)
  8. alpha - Methyl styrene
  9. alpha - Methyl styrene (ACGIH:OSHA)
  1. alpha - Methyl styrene, fume
  2. alpha - Methyl - styrol (German)
  3. alpha - Methylstyreen (Dutch)
  4. alpha - Methylstyrene
  5. alpha - Metil - stirolo (Italian)
  6. as - Methylphenylethylene
  7. beta - Phenylpropene
  8. beta - Phenylpropylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
91 mg mild AMIHAB 14,387,1956
skin
rabbit
1,00% moderate AMIHAB 14,387,1956


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sister chromatid exchange human lymphocyte 330 Ámol/L MUREAV 116,379,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 0.4 gm/m3/1 hour N/R TPKVAL 6,6,1964
inhalation
guinea pig
lowest published lethal concentration: 3,000 ppm N/R 28ZRAQ -,131,1960
inhalation
human
lowest published toxic concentration: 600 ppm Olfaction: Other olfaction effects

Eye: Other eye effects
AMIHAB 14,387,1956
inhalation
human
lowest published toxic concentration: 600 ppm Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGH* -,203,1990
inhalation
mouse
lowest published toxic concentration: 0.4 gm/m3/2 hour Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Fatty liver degeneration
TPKVAL 6,6,1964
inhalation
mouse
lowest published toxic concentration: 0.4 gm/m3 Skin: After systemic exposure: Dermatitis, other TPKVAL 6,6,1964
inhalation
rat
lowest published lethal concentration: 3,000 ppm N/R 28ZRAQ -,131,1960
oral
mouse
lethal dose (50 percent kill): 4,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 28(12),14,1963
oral
mouse
lethal dose (50 percent kill): 50,000 mg/kg N/R VCVGH* -,203,1990
oral
mouse
lethal dose : 3,000 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 6,6,1964
oral
rat
lethal dose (50 percent kill): 4,900 mg/kg N/R AMIHAB 14,387,1956
skin
mouse
lowest published toxic dose: 100 pph/1 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 6,6,1964
skin
rabbit
lowest published lethal dose: 16 mL/kg N/R UCDS** 5/24/1977
skin
rabbit
lowest published toxic dose: 100 pph/1 hour Skin: After topical application: Primary irritation TPKVAL 6,6,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 3,000 ppm/7 hour/24 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGH* -,203,1990
inhalation
rat
lowest published toxic concentration: 50 mg/m3/6 hour/22 week- intermittent Behavioral: Muscle contraction or spasticity

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 28(12),14,1963
inhalation
rat
lowest published toxic concentration: 5 mg/m3/24 hour/13 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
GISAAA 31(2),3,1966
inhalation
rat
lowest published toxic concentration: 3,000 ppm/7 hour/24 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGH* -,203,1990
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/91 day- intermittent Liver: Liver function tests impaired TPKVAL 6,6,1964
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/213 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration

Blood: Changes in spleen
TPKVAL 6,6,1964
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/183 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 6,6,1964
oral
mouse
lowest published toxic dose: 15 gm/kg/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GISAAA 29(4),24,1964
oral
rat
lowest published toxic dose: 15 gm/kg/30 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count
GTPZAB 23(6),38,1979
oral
rat
lowest published toxic dose: 1,400 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,203,1990
oral
rat
lowest published toxic dose: 10.01 gm/kg/2 week- intermittent Ear: Change in cochlear structure or function ARTODN 79,346,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 100 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 100 ppm (480 mg/m3) DTLVS* 3,170,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 100 ppm (480 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (246 mg/m3), short term exposure limit 100 ppm(492 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (240 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 246 mg/m3 (50 ppm);
short term exposure limit 492 mg/m3 (100 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (480 mg/m3), short term exposure limit 150 ppm (720 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), VLE 100 ppm (492 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 250 mg/m3 (50 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 246 mg/m3, short term exposure limit 492 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm (485 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (240 mg/m3);
short term exposure limit 100 ppm (485 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 240 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (242 mg/m3);
short term exposure limit 100 ppm (483 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 20 ppm (98 mg/m3);
short term exposure limit 50 ppm (245 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (250 mg/m3),KZG- week 100 ppm (500 mg/m3), dayEC2006
Occupational Exposure Limit - THAILAND time-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (246 mg/m3);
short term exposure limit 100 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm;
short term exposure limit 100 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm;
short term exposure limit 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-METHYLSTYRENE-air 10 hour time-weighted average 50 ppm;
short term exposure limit 100 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1533;
Number of Industries 20;
Total Number of Facilities 1,933;
Number of Occupations 32;
Total Number of Employees Exposed 24,824
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1533;
Number of Industries 3;
Total Number of Facilities 354;
Number of Occupations 4;
Total Number of Employees Exposed 3,214


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as additive, plasticizer and copolymer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9275
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE

28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as additive, plasticizer and copolymer

NIOSH PROFILE (ARENES), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us