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Stannane, tricyclohexylhydroxy -

RTECS #: WH8750000

CAS #: 13121-70-5


UPDATE: May 2009 MW: 385.21 MF: C18H34OSn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Cyhexatin
  2. Cyhexatin (ACGIH)
  3. Dowco - 213
  4. ENT 27,395 - X
  5. ENT 27395
  6. M 3180
  7. Plictran
  8. Plictran 50W
  9. Plyctran
  1. TCTH
  2. Tin, tricyclohexylhydroxy -
  3. Tricyclohexylhydroxystannane
  4. Tricyclohexylhydroxytin
  5. Tricyclohexylstannanol
  6. Tricyclohexylstannium hydroxide
  7. Tricyclohexyltin hydroxide
  8. Tricyclohexylzinnhydroxid (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sister chromatid exchange human lymphocyte 25 mg/L MUREAV 321,219,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 108 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) EQSFAP 4,80,1975
oral
rabbit
lowest published toxic dose: 23.25 mg/kg (1-31 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
HBPTO* 2,1217,2001
skin
rabbit
lowest published toxic dose: 3 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) HBPTO* 2,1217,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 290 mg/m3 N/R GTPZAB 28(5),52,1984
inhalation
rat
lethal concentration (50 percent kill): 244 mg/m3 N/R GISAAA 49(2),74,1984
intraperitoneal
rat
lethal dose (50 percent kill): 13 mg/kg N/R DOWCC*
oral
cat
lethal dose (50 percent kill): >800 mg/kg Gastrointestinal: Nausea or vomiting EQSFAP 4,80,1975
oral
chicken
lethal dose (50 percent kill): 654 mg/kg N/R HBPTO* 2,1216,2001
oral
dog
lethal dose (50 percent kill): >800 mg/kg Gastrointestinal: Nausea or vomiting EQSFAP 4,80,1975
oral
domestic animal
lowest published lethal dose: 150 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Fluid intake
TXAPA9 31,66,1975
oral
guinea pig
lethal dose (50 percent kill): 780 mg/kg N/R HBPTO* 2,1216,2001
oral
monkey
lethal dose (50 percent kill): >800 mg/kg Gastrointestinal: Nausea or vomiting EQSFAP 4,80,1975
oral
mouse
lethal dose (50 percent kill): 275 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
GISAAA 47(7),80,1982
oral
quail
lethal dose (50 percent kill): 255 mg/kg N/R EQSFAP 4,80,1975
oral
rat
lethal dose (50 percent kill): 180 mg/kg N/R KSKZAN 16(2),59,1978
oral
rat
lowest published toxic dose: 50 mg/kg Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
HBPTO* 2,1216,2001
oral
rabbit
lethal dose (50 percent kill): 458 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
GISAAA 47(7),80,1982
subcutaneous
mammal (species unspecified)
lowest published toxic dose: 30 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HBTME* -,839,2007
skin
human
lowest published toxic dose: 11 g/kg/1 day Nutritional and Gross Metabolic: Changes in: Other metals HBPTO* 2,1218,2001
skin
rat
lethal dose (50 percent kill): 446 mg/kg N/R FAATDF 7,299,1986
skin
rabbit
lethal dose (50 percent kill): 2,422 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
GISAAA 47(7),80,1982
unreported route
mouse
lethal dose (50 percent kill): 780 mg/kg N/R TGANAK 16(1),45,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 270 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain EQSFAP 4,80,1975
oral
mammal (species unspecified)
lowest published toxic dose: 2,310 mg/kg/44 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 47(7),80,1982
oral
mouse
lowest published toxic dose: 1,201 mg/kg/4 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PCBPBS 6,270,1976
oral
mouse
lowest published toxic dose: 8,640 mg/kg/90 day- continuous Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EQSFAP 4,80,1975
oral
rat
lowest published toxic dose: 180 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA 49(2),74,1984
oral
rat
lowest published toxic dose: 2,700 mg/kg/90 day- continuous Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EQSFAP 4,80,1975
oral
rat
lowest published toxic dose: 2,190 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1217,2001
oral
rat
lowest published toxic dose: 730 mg/kg/2 year- continuous Liver: Other changes HBPTO* 2,1217,2001
oral
rat
lowest published toxic dose: 4,380 mg/kg/2 year- continuous Spinal Cord: Other degenerative changes HBPTO* 2,1217,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EQSFAP 4,80,1975
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,106,1998
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.4 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.02 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sn)/m3,KZG- week 0.2 mg(Sn)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYHEXATIN-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organotin compounds as Sn, 5504


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HBTME*
HUTOX*
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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