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Sodium borate, decahydrate

RTECS #: VZ2275000

CAS #: 1303-96-4


UPDATE: May 2009 MW: 381.42 MF: B4O7•2Na•10H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Antipyonin
  2. Borascu
  3. Borates, tetra, sodium salt, decahydrate (ACGIH)
  4. Borates, tetra, sodium salts (decahydrate)
  5. Borax (8CI)
  6. Borax decahydrate
  7. Boricin
  8. Disodium tetraborate decahydrate
  9. Gertley borate
  1. Jaikin
  2. Neobor
  3. Sodium biborate decahydrate
  4. Sodium pyroborate decahydrate
  5. Sodium tetraborate decahydrate
  6. Solubor
  7. Three Elephant
  8. Tronabor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
Drosophila melanogaster
714 ppm SOGEBZ 10,601,1974
specific locus test oral
Drosophila melanogaster
714 ppm SOGEBZ 10,601,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 70 gm/kg (26 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 70 gm/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 70 gm/kg (90 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 37 gm/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TXAPA9 23,351,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 2,711 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity
AIPTAK 143,144,1963
intravenous
mouse
lethal dose (50 percent kill): 1,320 mg/kg N/R 14KTAK -,693,1964
oral
dog
lowest published lethal dose: 3 gm/kg N/R HBAMAK 4,1289,1935
oral
guinea pig
lethal dose (50 percent kill): 5,330 mg/kg N/R 14KTAK -,693,1964
oral
infant
lowest published lethal dose: 1 gm/kg N/R PCOC** -,144,1966
oral
man
lowest published lethal dose: 709 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting
JAMAAP 76,378,1921
oral
mouse
lethal dose (50 percent kill): 2 gm/kg N/R 14KTAK -,693,1964
oral
rat
lethal dose (50 percent kill): 2,660 mg/kg N/R FMCHA2 -,C48,1991
subcutaneous
rabbit
lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1289,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 35 gm/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 70 gm/kg/90 day- continuous Brain and Coverings: Changes in brain weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 377 gm/kg/2 year- continuous Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 23,351,1972
oral
rat
lowest published toxic dose: 18,524 mg/kg/70 day- continuous Endocrine: Changes in spleen weight

Blood: Other changes

Related to Chronic Data: Changes in testicular weight
BECTA6 25,782,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3;short term exposure limit 6 mg/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,90,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3, short term exposure limit 6 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.2 mg/m2, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg/m3;
short term exposure limit 5 mg/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORATES, decahydrate-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1956;
Number of Industries 196;
Total Number of Facilities 29,342;
Number of Occupations 132;
Total Number of Employees Exposed 442,072;
Total Number of Female Employees Exposed 88,646
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6986;
Number of Industries 3;
Total Number of Facilities 143;
Number of Occupations 4;
Total Number of Employees Exposed 1,615;
Total Number of Female Employees Exposed 53


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in ant poisons, for fly control around refuse and manure piles, as a larvicide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in ant poisons, for fly control around refuse and manure piles, as a larvicide

NIOSH PROFILE (BORON and ITS COMPOUNDS), SRC, 10/77

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 1344-90-7
ALT CAS #: 12447-40-4
ALT CAS #: 61028-24-8
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