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Silica, crystalline - quartz

RTECS #: VV7330000

CAS #: 14808-60-7


UPDATE: May 2009 MW: 60.09 MF: O2Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Agate
  2. Amethyst
  3. Chalcedony
  4. Cherts
  5. Crystalline silica
  6. Crystallized silicon dioxide
  7. D & D
  8. DQ12
  9. Flint
  10. Flintshot
  11. Gold bond R
  12. Imsil
  13. Min - U - Sil
  14. Novaculite
  15. Onyx
  16. Quartz
  17. Quartz silica
  18. Quazo puro (Italian)
  19. Rock crystal
  1. Rose quartz
  2. SF 35
  3. Sand
  4. Sicron F 300
  5. Siderite (SiO2)
  6. Sikron F 100
  7. Sil - Co - Sil
  8. Silica
  9. Silica dust
  10. Silica flour (powdered crystalline silica)
  11. Silica, crystalline quartz (ACGIH:OSHA)
  12. Silicon oxide, di - (sand)
  13. Silver bond B
  14. Snowit
  15. TGL 16319
  16. Tiger - eye
  17. W 12
  18. W 12 (Filler)
  19. alpha - Quartz


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human other cell types 120 mg/L/24 hour EMMUEG 48,151,2007
DNA damage human other cell types 120 mg/L EMMUEG 48,151,2007
DNA damage intratracheal
rat
3 mg/kg TXAPA9 189,84,2003
micronucleus test hamster lung 160 g/cm2 MUREAV 335,27,1995
micronucleus test human lung 40 g/cm2 MUREAV 335,27,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 50 mg/m3/6 hour/71 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ENVRAL 40,499,1986
implant
mouse
lowest published toxic dose: 4,000 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 22,825,1968
implant
rat
lowest published toxic dose: 900 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Tumors at site of application
AICCA6 10,119,1954
implant
rat
toxic dose : 4,554 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CORTBR 88,223,1972
intrapleural
hamster
lowest published toxic dose: 83 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
31BYAP -,92,1974
intrapleural
rat
lowest published toxic dose: 90 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
JNCIAM 57,509,1976
intrapleural
rat
toxic dose : 200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
JNCIAM 48,797,1972
intrapleural
rat
toxic dose : 100 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Lung, Thorax, or Respiration: Tumors
BJCAAI 41,908,1980
intrapleural
rat
toxic dose : 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Tumors
AIHAAP 41,836,1980
intrapleural
rat
toxic dose : 100 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JJIND8 79,797,1987
intraperitoneal
rat
lowest published toxic dose: 45 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
ZHPMAT 162,467,1976
intraperitoneal
rat
toxic dose : 90 mg/kg/4 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
JNCIAM 57,509,1976
intraperitoneal
rat
toxic dose : 450 mg/kg/4 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NATWAY 59,318,1972
intratracheal
rat
lowest published toxic dose: 111 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CREMEX 2,243,1986
intratracheal
rat
lowest published toxic dose: 100 mg/kg/19 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
EVHPAZ 34,47,1980
intravenous
rat
lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
JNCIAM 57,509,1976


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 16 million particles per cubic foot/8 hour/17.9 year- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
NTIS** PB246-697
inhalation
human
lowest published lethal concentration: 300 g/m3/10 year- intermittent Liver: Other changes ANYAA9 271,324,1976
inhalation
mouse
lowest published toxic concentration: 40 mg/kg Lung, Thorax, or Respiration: Other changes TOXID9 72,45,2003
inhalation
mouse
lowest published toxic concentration: 40 mg/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 72(Suppl 1),372,2003
inhalation
rat
lowest published toxic concentration: 200 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Changes in: Fe
AJPHAP 267,L686,1994
inhalation
rat
lowest published toxic concentration: 1 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,213,2005
inhalation
rat
lowest published toxic concentration: 248 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,306,2008
implant
rabbit
lowest published toxic dose: 20 mg/kg Lung, Thorax, or Respiration: Fibrosing alveolitis

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 183,46,2002
intratracheal
mouse
lethal dose : >20 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARDSBL 141(Suppl),A3-A937,1990
intratracheal
mouse
lowest published toxic dose: 16.7 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema TOXID9 72,44,2003
intratracheal
mouse
lowest published toxic dose: 80 mg/kg Lung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 185,1,2002
intratracheal
mouse
lowest published toxic dose: 80 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 72(Suppl 1),353,2003
intratracheal
mouse
lowest published toxic dose: 100 mg/kg Tumorigenic: Increased incidence of tumors in susceptible strains TOLED5 142,71,2003
intratracheal
mouse
lowest published toxic dose: 100 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Acute pulmonary edema
TOXID9 60,423,2001
intratracheal
rat
lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) BJIMAG 10,9,1953
intratracheal
rat
lowest published lethal dose: 250 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes
JTEHD6 19,403,1986
intratracheal
rat
lowest published toxic dose: 240 mg/kg/1 hour Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
IVIEM* -,453,1985
intratracheal
rat
lowest published toxic dose: 1.5 mg/kg Lung, Thorax, or Respiration: Fibrosis (interstitial) ARTODN 74,716,2001
intratracheal
rat
lowest published toxic dose: 15.69 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,43,2003
intratracheal
rat
lowest published toxic dose: 25 mg/kg Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Other changes
TOXID9 72,45,2003
intratracheal
rat
lowest published toxic dose: 150 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 72(Suppl 1),372,2003
intratracheal
rat
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXAPA9 194,111,2004
intratracheal
rat
lowest published toxic dose: 1,250 g/kg Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 149,255,2004
intratracheal
rat
lowest published toxic dose: 100 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 155,353,2005
intratracheal
rat
lowest published toxic dose: 30 mg/kg Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes
TOXID9 66,76,2002
intratracheal
rat
lowest published toxic dose: 50 mg/kg Lung, Thorax, or Respiration: Other changes TOXID9 66,98,2002
intratracheal
rat
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increased immune response
TOXID9 78,191,2004
intratracheal
rat
lowest published toxic dose: 5 mg/kg Lung, Thorax, or Respiration: Consolidation

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,382,2004
intratracheal
rat
lowest published toxic dose: 1 mg/kg N/R TOXID9 90,214,2006
intratracheal
rat
lowest published toxic dose: 1 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 225,119,2006
intratracheal
rat
lowest published toxic dose: 150 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOLED5 158,1,2005
intravenous
dog
lowest published lethal dose: 20 mg/kg N/R BIJOAK 27,1007,1933
intravenous
mouse
lowest published lethal dose: 40 mg/kg N/R JNCIAM 1,241,1940
intravenous
rat
lowest published lethal dose: 90 mg/kg N/R JNCIAM 57,509,1976
oral
rat
lowest published toxic dose: 120 gm/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
EPASR* #86940001000,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
domestic animal
lowest published toxic concentration: 1,000 gm/m3/10 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
EXLRDA 15,409,1989
inhalation
guinea pig
lowest published toxic concentration: 28 mg/m3/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXAPA9 68,152,1983
inhalation
hamster
lowest published toxic concentration: 3 mg/m3/6 hour/78 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight
INHTE5 10,699,1998
inhalation
monkey
lowest published toxic concentration: 10 mg/m3/818 day- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 72,44,2003
inhalation
mouse
lowest published toxic concentration: 1,475 g/m3/8 hour/21 week- intermittent Lung, Thorax, or Respiration: Other changes ENVRAL 39,331,1986
inhalation
mouse
lowest published toxic concentration: 4,932 g/m3/24 hour/39 week- continuous Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 21,298,1980
inhalation
mouse
lowest published toxic concentration: 160 mg/kg/2 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Autoimmune (multiple organ involvement)
TXCYAC 195,167,2004
inhalation
rat
lowest published toxic concentration: 80 mg/m3/26 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
GTPZAB 31(1),24,1987
inhalation
rat
lowest published toxic concentration: 108 mg/m3/6 hour/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 107,350,1991
inhalation
rat
lowest published toxic concentration: 58 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count
FCTOD7 29,341,1991
inhalation
rat
lowest published toxic concentration: 15 mg/m3/26 week- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 72,44,2003
inhalation
rat
lowest published toxic concentration: 0.74 mg/m3/2 year- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 72,44,2003
inhalation
rat
lowest published toxic concentration: 10 mg/m3/75 day- intermittent Lung, Thorax, or Respiration: Other changes TOXID9 72,44,2003
inhalation
rat
lowest published toxic concentration: 6.2 mg/m3/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response
TOXID9 78,11,2004
inhalation
rat
lowest published toxic concentration: 15 mg/m3/79 day- intermittent Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 1,81,2001
inhalation
rat
lowest published toxic concentration: 25 mg/m3/5 day- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Increase in cellular immune response
TOXID9 90,213,2006
intratracheal
rat
lowest published toxic dose: 2.88 mg/kg/12 week- intermittent Blood: Other changes

Blood: Changes in leukocyte (WBC) count
TXCYAC 175,63,2002
intratracheal
rat
lowest published toxic dose: 11.52 mg/kg/12 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Blood: Changes in leukocyte (WBC) count
TXCYAC 175,63,2002
intratracheal
rat
lowest published toxic dose: 240 g/kg/12 week- intermittent Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Decrease in cellular immune response
TXCYAC 175,63,2002
intratracheal
rat
lowest published toxic dose: 960 g/kg/12 week- intermittent Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 175,63,2002
intratracheal
rat
lowest published toxic dose: 300 g/kg/12 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 66,353,2002
intratracheal
rat
lowest published toxic dose: 21.75 mg/kg/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,105,2008
intratracheal
rat
lowest published toxic dose: 144 mg/kg/28 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,105,2008
intratracheal
rat
lowest published toxic dose: 203 mg/kg/28 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,105,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg/m3 (respirable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 68,41,1997
TOXICOLOGY REVIEW
31BYAP -,94,1974
TOXICOLOGY REVIEW
TOLED5 127,83,2002
TOXICOLOGY REVIEW
TOLED5 140-141,223,2003
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,14,2005
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - respirable dust in air time-weighted average 10 mg/m3/% resp. SiO2+2 DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD - total dust in air time-weighted average 30 mg/m3/2(SiO2+3) DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 mg/m3/(% resp SiO2+2) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 mg/m3/(% resp SiO2+2) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 30 mg/m3/(%SiO2+2), total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 250 million particles per cubic foot/(%SiO2+5) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 250 million particles per cubic foot/(%SiO2+5) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3 (resp. dust), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3 (respirable), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.3 mg/m3 (total), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, (resp), FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.03 mg/m3 (respirable), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3 (respirable), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.075 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m3 (respirable dust), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3 (resp. dust), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.3 mg/m3 (total dust), JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.15 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 10 mg/m3 (resp. dust), JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 30 mg/m3 (total dust), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.3 mg/m3 (respirable), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, crystalline quartz-air Carcinogen;
10 hour time-weighted average 0.05 mg/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 66495;
Number of Industries 59;
Total Number of Facilities 4,077;
Number of Occupations 82;
Total Number of Employees Exposed 81,221
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6478;
Number of Industries 2;
Total Number of Facilities 135;
Number of Occupations 10;
Total Number of Employees Exposed 8,927;
Total Number of Female Employees Exposed 741
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 66495;
Number of Industries 254;
Total Number of Facilities 53,724;
Number of Occupations 173;
Total Number of Employees Exposed 944,731;
Total Number of Female Employees Exposed 112,888


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a mineral, natural or synthetic fiber
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 36, 1981
NIOSH Analytical Method, 1994: Silica, crystalline in coal mine dust, by IR, 7603
NIOSH Analytical Method, 1994: Silica, crystalline, by XRD, 7500; by VIS, 7600; by IR, 7602
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID142
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE

31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
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Used as a mineral, natural or synthetic fiber

RTECS Compound Description:
   Tumorigen
   Organometallic
   Mutagen
   Human Data

ALT CAS #: 1317-79-9
Click Here for Additional Information about RTECS

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