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2 - Propenenitrile, 2 - methyl -

RTECS #: UD1400000

CAS #: 126-98-7


UPDATE: May 2009 MW: 67.10 MF: C4H5N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Cyanopropene - 1
  2. 2 - Methylpropenenitrile
  3. Isopropene cyanide
  4. Isopropenylnitrile
  5. Methacrylonitrile
  1. Methylacrylonitrile
  2. Methylacrylonitrile (ACGIH)
  3. RCRA waste number U152
  4. USAF ST - 40
  5. alpha - Methylacrylonitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg N/R JIHTAB 31,113,1949
eye
rabbit
500 mg/24 hour mild 85JCAE -,901,1986
skin
rabbit
200 mg mild JIHTAB 31,113,1949
skin
rabbit
500 mg/24 hour mild 85JCAE -,901,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 20,365,1993
oral
rat
lowest published toxic dose: 350 mg/kg (1-7 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
BECTA6 48,696,1992
oral
rat
lowest published toxic dose: 150 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus TXAPA9 163,149,2000
oral
rat
lowest published toxic dose: 20 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB97-176390
oral
rat
lowest published toxic dose: 20 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral
NTIS** #PB97-176390


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 52 ppm/7 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
AIHAAP 29,202,1968
inhalation
guinea pig
lethal concentration (50 percent kill): 88 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AIHAAP 29,202,1968
inhalation
mouse
lethal concentration (50 percent kill): 36 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AIHAAP 29,202,1968
inhalation
rat
lethal concentration (50 percent kill): 328 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 29,202,1968
inhalation
rat
lethal concentration (50 percent kill): 440 ppm/4 hour Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HALRE* 10/1/1968
inhalation
rabbit
lethal concentration (50 percent kill): 37 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AIHAAP 29,202,1968
intraperitoneal
mouse
lowest published lethal dose: 15 mg/kg N/R JIHTAB 31,113,1949
oral
mouse
lethal dose (50 percent kill): 17 mg/kg N/R JUZIAG 94,664,1985
oral
mouse
lowest published toxic dose: 3.15 mg/kg Blood: Other changes TOXID9 72,319,2003
oral
mouse
lowest published lethal dose: 26 mg/kg Lung, Thorax, or Respiration: Respiratory depression TXAPA9 205,116,2005
oral
rat
lethal dose (50 percent kill): 120 mg/kg N/R GTPZAB 29(5),37,1985
oral
rat
lowest published toxic dose: 60 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JJTHEC 65,523,2002
oral
rat
lowest published toxic dose: 50 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
DCTODJ 28,187,2005
oral
rat
lowest published toxic dose: 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases DCTODJ 28,187,2005
oral
rat
lowest published toxic dose: 100 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
DCTODJ 28,187,2005
oral
rat
lowest published toxic dose: 60 mg/kg Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TOXID9 60,404,2001
oral
rat
lowest published toxic dose: 60 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) TOXID9 60,404,2001
oral
rabbit
lethal dose (50 percent kill): 16 mg/kg N/R GTPZAB 29(5),37,1985
skin
rat
lethal dose (50 percent kill): 2,080 mg/kg N/R GTPZAB 29(5),37,1985
skin
rabbit
lethal dose (50 percent kill): 12,500 g/kg N/R NTIS** OTS0534646


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 109 ppm/7 hour/91 day- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 29,202,1968
intramuscular
rat
lowest published toxic dose: 2,940 mg/kg/21 week- intermittent Liver: Changes in liver weight NTIS** #PB97-176390
intramuscular
rat
lowest published toxic dose: 294 mg/kg/21 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB97-176390
oral
rat
lowest published toxic dose: 5,400 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** PB97-176390
oral
rat
lowest published toxic dose: 420 mg/kg/7 day- intermittent Liver: Other changes

Liver: Changes in liver weight
JJTHEC 65,523,2002
oral
rat
lowest published toxic dose: 3,150 mg/kg/21 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 77,233,2003
oral
rat
lowest published toxic dose: 14,400 mg/kg/2 year- intermittent Olfaction: Change in olfactory nerve

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 77,233,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (3 mg/m3) (skin) DTLWS* 3,22,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (2.7 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (2.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (3 mg/m3), short term exposure limit 3 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (3 mg/m3), Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (3 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (3 mg/m3);
short term exposure limit 2 ppm (6 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (2.7 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (2.8 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLACRYLONITRILE-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5279;
Number of Industries 3;
Total Number of Facilities 58;
Number of Occupations 2;
Total Number of Employees Exposed 213


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-47, October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HALRE* E. I. du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine report NO. 226-68
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JUZIAG Juzen Igakkai Zasshi. Journal of Juzen Medical Society. (Kanazawa Daigaku Juzen Igakkai, 13-1 Takara-machi, Kanazawa 920, Japan) V.1- 1896-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Primary Irritant

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